研究成果（立花誠）

1. 研究成果
2. 計画研究A01 - 立花誠

1. 021

   Hashimoto D, Hirashima T, Yamamura H, Kataoka T, Fujimoto K, Hyuga T, Yoshiki A, Kimura K, Kuroki S, Tachibana M, Suzuki K, Yamamoto N, Morioka S, Sasaki T, Yamada G.

   "Dynamic erectile responses of a novel penile organ model utilizing two photon excitation microscopy (TPEM)."

   Biol Reprod 2021 104: 875–886.

2. 020

   Kudo Y, Nakagawa H, Tanaka Y, Ijichi H, Ikenoue T, Ishizawa T, Hasegawa K, Tachibana M, Shinkai Y, Koike K.

   "Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis."

   Cell Death Dis 2021 12: 99–111.

3. 019

   宮脇慎吾・立花誠.

   「マウスの性決定遺伝子Sryにおける「隠れエキソン」の発見と、それがコードする真の性決定因子SRY-Tの発見」

   『実験医学』 2020 39: 571–574.

4. 018

   Kato H, Tateishi K, Fujiwara H, Ijichi H, Yamamoto K, Nakatsuka T, Kakiuchi M, Sano M, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Otsuka M, Hirata Y, Tachibana M, Shinkai Y, Koike K.

   "Deletion of histone methyltransferase G9a suppresses mutant Kras-driven pancreatic carcinogenesis."

   Cancer Genomics Proteomics 2020 17: 695–705.

5. 017

   Miyawaki S, Kuroki S, Maeda R, Okashita N, Koopman P, Tachibana M.

   "The mouse Sry locus harbors a cryptic exon that is essential for male sex determination."

   Science 2020 370: 121–124.

   プレスリリース マウスの性決定遺伝子Sryにはオス化に必須の”隠れ"エキソンが存在する

6. 016

   Kuroki S, Maeda R, Yano M, Kitano S, Miyachi H, Fukuda M, Shinkai Y, Tachibana M.

   "H3K9 demethylases JMJD1A and JMJD1B control prospermatogonia to spermatogonia transition in mouse germline."

   Stem Cell Rep 2020 15: 424–438.

7. 015

   Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, Kimura H, Shinkai Y, Tachibana M, Nifuji A.

   "G9a is involved in the regulation of critical bone formation through activation of Runx2 function during development."

   Bone 2020 137: e115332.

8. 014

   Someda M, Kuroki S, Miyachi H, Tachibana M, Yonehara S.

   "Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis."

   Cell Death Differ 2020 27: 1539–1553.

9. 013

   Okashita N, Kuroki S, Maeda R, Tachibana M.

   "TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression."

   Sci Rep 2019 9:13462.

10. 012

    Au Yeung WK, Brind'Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H.

    "Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection."

    Cell Rep 2019 27: 282–293.

11. 011

    Fukuda M, Sakaue-Sawano A, Shimura C, Tachibana M, Miyawaki A, Shinkai Y.

    "G9a-dependent histone methylation can be induced in G1 phase of cell cycle."

    Sci Rep 2019 9: 956.

12. 010

    立花誠.

    「性とは何か：雌雄間の多様な性 立花誠博士に聞く」

    『現代化学』 2019 574: 40–43.

13. 009

    Tatsumi D, Hayashi Y, Endo M, Kobayashi H, Yoshioka T, Kiso K, Kanno S, Nakai Y, Maeda I, Mochizuki K, Tachibana M, Koseki H, Okuda A, Yasui A, Kono T, Matsui Y.

    "DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells."

    PLoS One 2018 13: e0205969.

14. 008

    前田亮・立花誠.

    「タンパク質・核酸の分子修飾 – メチル化」

    『生体の科学［増大特集］』 2018 69: 404–405.

15. 007

    岡下修己・立花誠.

    「タンパク質・核酸の分子修飾 – 脱メチル化」

    『生体の科学［増大特集］』 2018 69: 406–407.

16. 006

    Masaki K, Sakai M, Kuroki S, Jo JI, Hoshina K, Fujimori Y, Oka K, Amano T, Yamanaka T, Tachibana M, Tabata Y, Shiozawa T, Ishizuka O, Hochi S, Takashima S.

    "FGF2 has distinct molecular functions from GDNF in the mouse germline niche."

    Stem Cell Reports 2018 10: 1782–1792.

17. 005

    Kuroki S, Tachibana M.

    "Epigenetic regulation of mammalian sex determination (review)."

    Mol Cell Endocrinol 2018 15: 31–38.

18. 004

    Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi H, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M.

    "Combined loss of JMJD1A and JMJD1B reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis."

    Stem Cell Rep 2018 10: 1340–1354.

19. 003

    Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M.

    "Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance."

    PLoS Genet 2017 13:e1007034.

20. 002

    Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A.

    "Essential roles of G9a in cell proliferation and differentiation during tooth development."

    Exp Cell Res 2017 357: 202–210.

21. 001

    Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, Koike K.

    "Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation."

    Oncogene 2017 36: 6262–6271.