業績

原著論文 2003年以降

  • Totsuka, T. And Ohsugi, M. (2020) Production of mouse androgenetic embryos using spindle perturbation. Sci. Rep. 10: 6556.　DOI: 10.1038/s41598-020-63010-x　LINKLINK
  • Soeda, S., Yamada-Nomoto, K., Michiue, T., and Ohsugi, M. (2018) RSK-MASTL pathway delays meiotic exit in mouse zygotes to ensure paternal chromosome stability. Dev. Cell, 47, 363-376.　LINKLINK
    • 　
  • Shintomi, K., Inoue, F., Watanabe, H., Ohsumi, K., Ohsugi, M., and Hirano, T. (2017) Mitotic chromosome assembly despite nucleosome depletion in Xenopus egg extracts. Science 356,　1284-1287.　LINK
  • Soeda, S., Yamada-Nomoto, K. and Ohsugi, M. (2016) The microtubule-binding and coiled-coil domains of Kid are required for turning off the polar ejection force at anaphase. J. Cell Sci., 129,　3609-3619.　IN THIS ISSUE
  • Ohashi, T., Ymamoto, T., Yamanashi, Y. and Ohsugi, M. (2016) Human TUBG2 gene is expressed as two splice variant mRNAs and involved in cell growth. FEBS Lett., 590, 1053-1063. EDITOR'S CHOICE
  • Park, S.J., Shirahige, K., Ohsugi, M. and Nakai, K. (2014) DBTMEE: a database of transcriptome in mouse early embryos. Nucl. Acids Res. 43, D771-776
  • Park, S.J., Komata, M., Inoue, F., Yamada, K., Nakai, K., #Ohsugi, M. and #Shirahige, K. (2013) Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis. Genes Dev 27, 2736-2748. (#Co-corresponding authors)
  • Soeda, S., Yamada, K. and Ohsugi, M. (2013) Inactivation of mitogen-activated protein kinase is neither necessary nor sufficient for the onset of pronuclear formation in mouse oocytes. Genes Cells 18, 850-858.
  • Takahashi, A., Kikuguchi, C., Morita, M., Shimodaira, T., Tokai-Nishizumi, N., Yokoyama, K., Ohsugi, M., Suzuki, T. and Yamamoto, T. (2012) Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression. Biochem Biophys Res Commun. 419, 268-273
  • Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga, S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M., and Inaba, T. (2012) Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation. Mol Cell 47:694-706.
  • *Masuda, N., *Shimodaira, T., Shiu, S.J., Tokai-Nishizumi, N. Yamamoto, T., and Ohsugi, M. (2011) Microtubule stabilization triggers the plus-end accumulation of Kif18A/kinesin-8. Cell Struct. Funct. 2, 261-267. (*co-first authors)
  • Kitajima, T.S., Ohsugi, M. and Ellenberg, J. (2011) Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in Mammalian oocytes. Cell 146, 568-581.
  • Oshimori, N., Li, X., #Ohsugi, M. and #Yamamoto, T. (2009) Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. EMBO J. 28, 2066-2076. (#Co-corresponding authors)
  • Ohsugi M., Adachi K., Horai R., Kakuta S., Sudo K., Kotaki H., Tokai-Nishizumi N., Sagara H., Iwakura Y. and Yamamoto T.(2008) Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Cell, 132:771-782.
  • Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S and Imamoto N.(2008) Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol, 180:493-506.
  • Haraguchi K, Ohsugi M, Abe Y, Semba K, Akiyama T and Yamamoto T. (2008) Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. Oncogene, 27:274-284.
  • Bai C. Y.*, Ohsugi, M.*, Abe Y., and Yamamoto, T. ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. J Cell Sci, 120:2828-2837, 2007. (* equal contribution)
  • Oshimori, N., Ohsugi, M. and Yamamoto, T. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Nat Cell Biol, 8:1095-1101, 2006.
  • Abe, Y., Ohsugi, M., Haraguchi, K., Fujimoto, J. and Yamamoto T.: LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett, 580:782-788, 2006.
  • Tokai-Nishizumi N., Ohsugi, M., Suzuki, E. and Yamamoto T.: The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Mol Biol Cell, 16:5455-5463, 2005.
  • Kitajima, T.S. Hauf, S., Ohsugi M., Yamamoto, T. and Watanabe, Y.: Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr Biol, 15:353-359, 2005.
  • Shiroguchi, K. Ohsugi, M., Edamatsu, M., Yamamoto, T. and Toyoshima Y. Y.: The second microtubule-binding site of monomeric kid enhances the microtubule affinity. J Biol Chem, 278:22460-22465, 2003.
  • Yajima, J., Edamatsu, M., Watai-Nishi, J., Tokai-Nishizumi,. N., Yamamoto, T. and Toyoshima, Y.Y. The human chromokinesin Kid is a plus-end directed microtubule-based motor. EMBO J. 22 5: 1067-1074, 2003
  • Ohsugi, M., Tokai-Nishizumi, N., Shiroguchi, K., Toyoshima, Y.Y., Inoue, J. and Yamamoto T.: Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes. EMBO J, 22:2091-2103, 2003.

日本語総説

  • 大杉美穂　渡海-西住紀子　山本雅　”Kidによる染色体コンパクションと核膜形成”　炎症と免疫（2009）vol 17 No 2 p154-159
  • 大杉美穂　山本雅　”Kidは分裂後期染色体コンパクションを担い正常な核形成を保証する”細胞工学（2008）vol 17 No 8 p802-803
  • 大杉美穂　押森直木”　染色体分配のための紡錘体極のかたち作り”生化学（2008）vol 80 No 3 p210-214
  • 大杉美穂　押森直木　山本雅　”紡錘体極形成の新たなメカニズムーKizunaによる中心体の構造安定化の重要性”蛋白質核酸酵素 (2007) vol 52 No 8 p880-885
  • 大杉美穂　”染色体分配を制御する新しい中心体像”実験医学増刊号「染色体サイクル-複製・分配・組換え・修復・クロマチン制御のメカニズムとその異常による疾患」（2007）vol 25 No 5 p691-696