准教授 前田真吾(まえだしんご)
- 〒113-8657 東京都文京区弥生1-1-1
東京大学・大学院農学生命科学研究科・獣医臨床病理学研究室
前田 真吾
Tel: 03-5841-3096(7号館A棟203号室)
Tel: 03-5841-5420(動物医療センター)
Fax: 03-5841-3096
E-mail: amaeda@mail.ecc.u-tokyo.ac.jp
個人ホームページ: https://www.maedalab.com/
Shingo MAEDA, DVM, Ph.D. (Associate professor)
Laboratory of Veterinary Clinical Pathobiology,
Department of Veterinary Medical Sciences,
Graduate School of Agricultural and Life Sciences,
The University of Tokyo,
1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Tel: +81-3-5841-3096
Fax: +81-3-5841-3096
E-mail: amaeda@mail.ecc.u-tokyo.ac.jp
Homepage: https://www.maedalab.com/
専門分野
主要な研究テーマ
- 腫瘍組織への制御性T細胞浸潤機構の解明
- 腫瘍組織における血管新生促進機構の解明
- 慢性腸炎の病態解析
- アレルギー性疾患および慢性腎臓病におけるプロテアーゼの役割解明
履歴
- 1983年9月 兵庫県生まれ、静岡県育ち
- 2009年3月 岐阜大学農学部獣医学科卒業
- 2013年3月 東京大学大学院農学生命科学研究科獣医学専攻博士課程修了
- 2013年4月 東京大学大学院農学生命科学研究科 獣医薬理学研究室 特任研究員
- 2013年8月 東京大学大学院農学生命科学研究科 放射線動物科学研究室 特任助教
- 2015年4月 東京大学大学院農学生命科学研究科 獣医臨床病理学研究室 特任助教
- 2016年10月 同・助教
- 2022年4月 同・准教授 現在に至る
原著論文(英文:査読あり)
- Maeda S, Motegi T, Iio A, Kaji K, Goto-Koshino Y, Eto S, Ikeda N, Nakagawa T, Nishimura R, Yonezawa T, Momoi Y. Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer. Journal for ImmunoTherapy of Cancer. 2022;10:e003731.
- Maeda S, Sakai K, Kaji K, Iio A, Nakazawa M, Motegi T, Yonezawa T, Momoi Y. Lapatinib as first-line treatment for muscle-invasive urothelial carcinoma in dogs. Scientific Reports. 2022; 12(1):4.
- Kaji K, Yonezawa T, Momoi Y, Maeda S. Detection of Canine Urothelial Carcinoma Cells in Urine Using 5-Aminolevulinic Acid. Animals. 2022; 12(4):485.
- Yokota S, Yonezawa T, Momoi Y, Maeda S. Sorafenib inhibits tumor cell growth and angiogenesis in canine transitional cell carcinoma. Journal of Veterinary Medical Science. 2022; 84(5):666-674.
- Kim H, Yonezawa T, Maeda S, Tamahara S, Matsuki N. Increases in serum carbonylated protein levels of dogs with hypercortisolism. Endocr J. 2022 Dec 28;69(12):1387-1394. doi: 10.1507/endocrj.EJ22-0075. Epub 2022 Jul 21
- Nishi R, Uchida M, Nakahara M, Maeda S, Hayashi A, Iwatani N, Tanaka T, Yonezawa T. Adverse effect of repeated treatment with 5-aminoleveuic acid in healthy cats and those with chronic kidney disease. ALA-Porphyrin Science. 2022; 11(1):1-12.
- Hirose Y, Uchida M, Tsuboi M, Nakagawa T, Yaga L, Maeda S, Momoi Y, Kuriki Y, Kamiya M, Urano Y, Yonezawa T. Rapid visualization of mammary gland tumor lesions of dogs using the enzyme-activated fluorogenic probe; γ-glutamyl hydroxymethyl rhodamine green. J Vet Med Sci. 2022; 84(4):593-599.
- Maeda S, Yoshitake R, Chambers JK, Uchida K, Eto S, Ikeda N, Nakagawa T, Nishimura R, Goto-Koshino Y, Yonezawa T, Momoi Y. BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs. Veterinary Pathology. 2021; 58(5):971-980.
- Sakai K, Chambers JK, Uchida K, Nakagawa T, Nishimura R, Yonezawa T, Maeda S. ErbB2 copy number gain is associated with adverse outcome in canine mammary carcinoma. Journal of Veterinary Medical Science. 2021; 83(3):370-377.
- Nishi R, Motegi T, Maeda S, Tamahara S, Momoi Y, Matsuki N, Yonezawa T. Clinical assessment of testosterone analogues for urethral sphincter mechanism incompetence in ten spayed female dogs. Journal of Veterinary Medical Science. 2021; 83(2):274-279.
- Sakai K, Shinohara Y, Kaji K, Yonezawa T, Momoi Y, Maeda S. Human epidermal growth factor receptor 2 is overexpressed in canine prostate carcinoma. Translational and Regulatory Science. 2021; 3(1):1-8.
- Kaji K, Kaji N, Hori M, Sakai K, Yonezawa T, Maeda S. Protease-activated receptor-2 is associated with adverse outcomes in canine mammary carcinoma. Veterinary Pathology. 2021; 58(1):53-62.
- Maeda S, Nakazawa M, Uchida M, Yoshitake R, Nakagawa T, Nishimura R, Miyamoto R, Bonkobara M, Yonezawa T, Momoi Y. Foxp3+ Regulatory T Cells Associated With CCL17/CCR4 Expression in Carcinomas of Dogs. Veterinary Pathology. 2020; 57(4):497-506.
- Iio A, Kaji K, Kaji N, Hori M, Yonezawa T, Momoi Y, Maeda S. Expression analysis of protease-activated receptor-2 in cats. Veterinary Immunology and Immunopathology. 2020; 229:110115.
- Sakai K, Maeda S, Saeki K, Yoshitake R, Goto-Koshino Y, Nakagawa T, Nishimura R, Yonezawa T, Matsuki N. ErbB2 copy number aberration in canine urothelial carcinoma detected by a digital polymerase chain reaction assay. Veterinary Pathology. 2020; 57(1):56-65.
- Iio A, Maeda S, Yonezawa T, Momoi Y, Motegi T. Isolated growth hormone deficiency in a Chihuahua with a GH1 mutation. Journal of Veterinary Diagnostic Investigation. 2020; 32(5):733-736.
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Nakazawa M, Maeda S, Omori M, Kaji K, Yokoyama N, Nakagawa T, Chambers JK, Uchida K, Ohno K, Yonezawa T, Matsuki N. Duodenal expression of antimicrobial peptides in dogs with idiopathic inflammatory bowel disease and intestinal lymphoma. Vet J. 2019; 249:47-52.
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Tsuboi M+, Sakai K+, Maeda S, Chambers JK, Yonezawa T, Matsuki N, Uchida K, Nakayama H. Assessment of HER2 Expression in Canine Urothelial Carcinoma of the Urinary Bladder. Vet Pathol. 2019; 56(3):369-376.
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Maeda S, Murakami K, Inoue A, Yonezawa T, Matsuki N. CCR4 Blockade Depletes Regulatory T Cells and Prolongs Survival in a Canine.Model of Bladder Cancer. Cancer Immunol Res. 2019; 7(7):1175-1187.
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Nakazawa M, Maeda S, Yokoyama N, Nakagawa T, Yonezawa T, Ohno K, Matsuki N.
Sphingosine-1-phosphate (S1P) signaling regulates the production of intestinal IgA and its potential role in the pathogenesis of canine inflammatory bowel disease. J Vet Med Sci. 2019; 81(9):1249-1258.
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Uchida M, Uchida K, Maeda S, Yonezawa T. Expression of apoptosis inhibitor of macrophages in tissue macrophages, leukocytes and vascular endothelial cells of dogs. Tissue Cell. 2019; 58:112-120.
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Sakai K, Maeda S*, Saeki K, Nakagawa T, Murakami M, Endo Y, Yonezawa T, Kadosawa T, Mori T, Nishimura R, Matsuki N. Anti-tumour effect of lapatinib in canine transitional cell carcinoma cell lines. Veterinary and Comparative Oncology. 2018 16(4):642-649
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Inagaki S†, Maeda S†, Narita M, Nakamura T, Shimosawa T, Murata T*, Ohya Y*. Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy. Journal of Allergy and Clinical Immunology. 2018 142(5):1634-1636
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Maeda S*†, Tomiyasu H†, Tsuboi M, Inoue A, Ishihara G, Uchikai T, Chambers JK, Uchida K, Yonezawa T, Matsuki N. Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq. BMC Cancer. 2018; 18(1):472
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Sugimoto S, Maeda S*, Tsuboi M, Saeki K, Chambers JK, Yonezawa T, Fukushima K, Fujiwara R, Uchida K, Tsujimoto H, Matsuki N, Ohno K. Multiple acquired portosystemic shunts secondary to primary hypoplasia of the portal vein in a cat. Journal of Veterinary Medical Science. 2018; 80(6):874-877
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Hamabata T, Nakamura T, Masuko S, Maeda S, Murata T*. Production of lipid mediators across different disease stages of dextran sulfate sodium-induced colitis in mice. Journal of Lipid Research. 2018; jlr.M079095
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Sakai K, Maeda S*, Yamada Y, Chambers JK, Uchida K, Nakayama H, Yonezawa T, Matsuki N. Association of tumour-infiltrating regulatory T cells with adverse outcomes in dogs with malignant tumours. Veterinary and Comparative Oncology. 2018; 16: 330-336 (ジャーナルの表紙に掲載)
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Sakai K, Maeda S*, Yonezawa T, Matsuki N. Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response. Veterinary Immunology and Immunopathology. 2018; 195:1-6
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Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T*. Prostaglandin D2 metabolite in urine is an index of food allergy. Scientific Reports. 2017; 15;7(1):17687
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Maeda S*, Tsuboi M, Sakai K, Ohno K, Fukushima K, Kanemoto H, Hiyoshi-Kanemoto S, Goto-Koshino Y, Chambers JK, Yonezawa T, Uchida K, Matsuki N. Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs. Veterinary Pathology. 2017; 54(4):595-604
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Nakamura T, Fujiwara Y, Yamada R, Fujii W, Hamabata T, Lee MY, Maeda S, Aritake K, Roers A, Sessa WC, Nakamura M, Urade Y, Murata T*. Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice. Journal of Allergy Clinical Immunology. 2017; 140(2):630-632.e9
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Inoue A, Maeda S*, Kinoshita R, Tsuboi M, Yonezawa T, Matsuki N. Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma. Veterinary Immunology and Immunopathology. 2017; 190: 53-56
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Omori M, Maeda S*, Igarashi H, Ohno K, Sakai K, Yonezawa T, Horigome A, Odamaki T, Matsuki N. Fecal microbiome in dogs with inflammatory bowel disease and intestinal lymphoma. Journal of Veterinary Medical Science. 2017; 17;79(11):1840-1847
- Kobayashi K, Horikami D, Omori K, Nakamura T, Yamazaki A, Maeda
S, Murata T*. Thromboxane A2 exacerbates acute lung injury via
promoting edema formation. Scientific Reports. 2016; 6:32109
- Murakami K, Maeda S, Yonezawa T, Matsuki N*. CC chemokine ligand
2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in
canine idiopathic polyarthritis. Veterinary Immunology and
Immunopathology. 2016;182: 52-58.
- Uchida M, Saeki K, Maeda S, Tamahara S, Yonezawa T*, Matsuki N.
Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine
histiocytic sarcoma cell lines. Journal of Veterinary Medical Science.
2016;78(9): 1515-1520
- Murakami K, Maeda S, Yonezawa T, Matsuki N*. Synovial fluid
matrix metalloproteinase-2 and -9 activities in dogs suffering from
joint disorders. Journal of Veterinary Medical Science. 2016; 78(6):
1051-1054
- Maeda S, Ohno K*, Fujiwara-Igarashi A, Uchida K, Tsujimoto H.
Changes in Foxp3-positive Treg number in the intestine of dogs with
idiopathic inflammatory bowel disease and intestinal lymphoma.
Veterinary Pathology. 2016; 53(1): 102-112
- Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI,
Iwakura Y, Urade Y, Murata T*. PGD2 deficiency exacerbates food
antigen-induced mast cell hyperplasia. Nature Communications. 2015;
6:7514
- Nakashima K, Hiyoshi S, Ohno K*, Uchida K, Goto-Koshino Y, Maeda
S, Mizutani N, Takeuchi A,Tsujimoto H. Prognostic factors in dogs with
protein-losing enteropathy. Veterinary Journal. 2015; 205(1):28-32.
- Hiyoshi S, Ohno K*, Uchida K, Goto-Koshino Y, Nakashima K,
Fukushima K, Kanemoto H, Maeda S, Tsujimoto H. Association between
lymphocyte antigen receptor gene rearrangements and histopathological
evaluation in canine chronic enteropathy. Veterinary Immunology and
Immunopathology. 2015; 165(3-4):138-144.
- Goto-Koshino Y*, Mochizuki H, Sato M, Nakashima K, Hiyoshi S,
Fujiwara-Igarashi A, Maeda S, Nakamura K, Uchida K, Fujino Y, Ohno K,
Tsujimoto H. Construction of a multicolor GeneScan analytical system to
detect clonal rearrangements of immunoglobulin and T cell receptor
genes in canine lymphoid tumors. Veterinary Immunology and
Immunopathology. 2015; 165(1-2):81-87.
- Maeda S, Igarashi H, Ohno K*, Horigome A, Odamaki T, Tsujimoto H.
Effect of Oral Administration of Metronidazole or Prednisolone on Fecal
Microbiota in Dogs. PLoS One. 2014; 9(9): e107909.
- Maeda S, Ohno K*, Uchida K, Igarashi H, Goto-Koshino Y, Fujino Y,
Tsujimoto H. Intestinal Protease-Activated Receptor-2 and Fecal Serine
Protease Activity are Increased in Canine Inflammatory Bowel Disease
and May Contribute to Intestinal Cytokine Expression. Journal of
Veterinary Medical Science. 2014; 76(8): 1119-1127.
- Maeda S, Ohno K*, Fujiwara-Igarashi A, Tomiyasu H, Fujino Y,
Tsujimoto H. Methylation of TNFRSF13B and TNFRSF13C in duodenal mucosa
in canine inflammatory bowel disease and its association with decreased
mucosal IgA expression. Veterinary Immunology and Immunopathology.
2014; 160(1-2): 97-106.
- Maeda S, Nakamura T, Murata T*. Tumor suppressor prostaglandin
D2. Oncoscience. 2014; 1(6): 396-397.
- Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki
H, Murata T*. Mast cell-derived PGD2 inhibits colitis and
colitis-associated colon cancer in mice. Cancer Research. 2014; 74(11):
3011-3019.
- Igarashi H, Ohno K*, Maeda S, Kanemoto H, Fukushima K, Uchida K,
Tsujimoto H. Expression profiling of pattern recognition receptors and
selected cytokines in miniature dachshunds with inflammatory colorectal
polyps. Veterinary Immunology and Immunopathology. 2014; 159(1-2): 1-10.
- Fujiwara-Igarashi A, Goto-Koshino Y, Sato M, Maeda S, Igarashi H,
Takahashi M, Fujino Y, Tsujimoto H*. Prognostic significance of the
expression levels of the p16, p15, and p14 genes in dogs with
high-grade lymphoma. The Veterinary Journal. 2014; 199(2): 236-244.
- Kubota S, Ohno K*, Tsukamoto A, Maeda S, Murata Y, Nakashima K,
Fukushima K, Uchida K, Fujino Y, Tsujimoto H. Value of the 13C-Urea
Breath Test for Detection of Gastric Helicobacter spp. Infection in
Dogs Undergoing Endoscopic Examination. Journal of Veterinary Medical
Science. 2013; 75(8): 1049-1054.
- Fujiwara-Igarashi A, Goto-Koshino Y, Mochizuki H, Maeda S, Fujino
Y, Ohno K, Tsujimoto H*. Simultaneous Inactivation of the p16, p15 and
p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine
T-Lymphoid Tumor Cells. Journal of Veterinary Medical Science. 2013;
75: 733-42.
- Maeda S, Maeda S, Ohno K*, Kaji N, Hori M, Fujino Y, Tsujimoto H.
Protease-activated receptor-2 induces proinflammatory cytokine and
chemokine gene expression in canine keratinocytes. Veterinary
Immunology and Immunopathology. 2013; 153: 17-25.
- Maeda S, Ohno K*, Uchida K, Nakashima K, Fukushima K, Tsukamoto
A, Nakajima M, Fujino Y, Tsujimoto H. Decreased immunoglobulin A
concentrations in feces, duodenum, and peripheral blood mononuclear
cells of dogs with inflammatory bowel disease. Journal of Veterinary
Internal Medicine. 2013; 27: 47-55.
- Maeda S, Fujino Y*, Tamamoto C, Suzuki S, Fujita A, Takahashi M,
Ohno K, Uchida K, Tsujimoto H. Lymphangiomatosis of the systemic skin
in an old dog. Journal of Veterinary Medical Science. 2013; 75: 187-190.
- Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K,
Nakajima M, Goto-Koshino Y, Fujino Y, Tsujimoto H. Increased expression
of fractalkine and its receptor CX3CR1 in canine inflammatory bowel
disease and their possible role in recruitment of intraepithelial
lymphocytes. Veterinary Immunology and Immunopathology. 2012; 148:
226-235.
- Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K,
Tsukamoto A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Mucosal imbalance
of interleukin-1beta and interleukin-1 receptor antagonist in canine
inflammatory bowel disease. The Veteryanry Journal. 2012; 194: 66-70.
- Tsukamoto A, Ohno K*, Maeda S, Nakashima K, Fukushima K, Fujino
Y, Hori M, Tsujimoto H. Effect of mosapride on prednisolone-induced
gastric mucosal injury and gastric-emptying disorder in dogs. Journal
of Veterinary Medical Science. 2012; 74: 1103-1108.
- Maeda S, Ohno K*, Tsukamoto A, Nakashima K, Fukushima K,
Goto-Koshino Y, Fujino Y, Tsujimoto H. Molecular cloning and expression
analysis of the canine chemokine receptor CCR9. Veterinary Immunology
and Immunopathology. 2012; 145: 534-539.
- Maeda S, Ohno K*, Nakashima K, Fukushima K, Tsukamoto A, Suzuki
H, Fujiwara A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Molecular cloning
and characterization of canine fractalkine and its receptor CX3CR1.
Veterinary Immunology and Immunopathology. 2012; 145: 100-109.
- Tsukamoto A, Ohno K*, Irie M, Ohmi A, Maeda S, Nakashima K,
Fukushima K, Fujino Y, Uchida K, Tsujimoto H. A Case of Canine Multiple
Inflammatory Colorectal Polyps Treated by Endoscopic Polypectomy and
Argon Plasma Coagulation. Journal of Veterinary Medical Science. 2012;
74: 503-506.
- Tsukamoto A, Ohno K*, Maeda S, Nakashima K, Fukushima K, Fujino
Y, Tsujimoto H. Prokinetic effect of the 5-HT4R agonist mosapride on
canine gastric motility. Journal of Veterinary Medical Science. 2011;
73: 1635-1637.
- Tsukamoto A, Ohno K*, Tsukagoshi T, Maeda S, Nakashima K,
Fukushima K, Fujino Y, Takeuchi A, Tsujimoto H. Ultrasonographic
evaluation of vincristine-induced gastric hypomotility and the
prokinetic effect of mosapride in dogs. Journal of Veterinary Internal
Medicine. 2011; 25: 1461-1464.
- Tsukamoto A, Ohno K, Tsukagoshi T, Maeda S, Nakashima K,
Fukushima K, Fujino Y, Tsujimoto H. Real-time ultrasonographic
evaluation of canine gastric motility in the postprandial state.
Journal of Veterinary Medical Science. 2011; 73: 1133-1138.
- Maeda S, Ohno K*, Nakamura K, Uchida K, Nakashima K, Fukushima K,
Tsukamoto A, Goto-Koshino Y, Fujino Y, Tsujimoto H. Quantification of
chemokine and chemokine receptor gene expression in duodenal mucosa of
dogs with inflammatory bowel disease. Veterinary Immunology and
Immunopathology. 2011; 144: 290-298.
- Shibata S, Maeda S*, Maeda S, Chimura N, Kondo N, Fukata T.
Augmentation of CCL17 and CCL28 gene expression by TNF-alpha, IL-1beta,
or IFN-gamma in cultured canine keratinocytes. Research in Veterinary
Science. 2010; 88: 422-426.
- Shibata S, Maeda S*, Kondo N, Inoue A, Maeda S, Chimura N, Fukata
T. Effect of recombinant canine interferon-gamma on
granulocyte-macrophage colony-stimulating factor, transforming growth
factor-beta and CC chemokine ligand 17 mRNA transcription in a canine
keratinocyte cell line (CPEK). Veterinary Dermatology. 2010; 22: 24-30.
- Maeda S, Maeda S*, Shibata S, Chimura N, Fukata T. Molecular
cloning of canine protease-activated receptor-2 and its expression in
normal dog tissues and atopic skin lesions. Journal of Veterinary
Medical Science. 2009; 71: 577-582.
- Maeda S, Maeda S*, Shibata S, Chimura N, Fukata T. House dust
mite major allergen Der f 1 enhances proinflammatory cytokine and
chemokine gene expression in a cell line of canine epidermal
keratinocytes. Veterinary Immunology and Immunopathology. 2009; 131:
298-302.
商業誌記事(過去5年間)
- 前田真吾・大野耕一・中島 亘・福島健次郎・藤野泰人・辻本 元『イヌの炎症性腸疾患におけるフラクタルカインおよびその受容体CX3CR1
の関与』JVM 7月号、文永堂出版社、2012、pp. 557-560(執筆分)
- 前田真吾 『深遠なる腸管免疫1』Veterinary Immunology for Practitioners vol.
1、動物アレルギー検査株式会社、2016
- 前田真吾 『深遠なる腸管免疫2』Veterinary Immunology for Practitioners vol.
2、動物アレルギー検査株式会社、2016
- 前田真吾 『深遠なる腸管免疫3』Veterinary Immunology for Practitioners vol.
3、動物アレルギー検査株式会社、2016
- 前田真吾 『深遠なる腸管免疫4』Veterinary Immunology for Practitioners vol.
4、動物アレルギー検査株式会社、2017
- 前田真吾 『深遠なる腸管免疫5』Veterinary Immunology for Practitioners vol.
5、動物アレルギー検査株式会社、2017
所属学会・研究会
- 所属学会・研究会
- 日本獣医学会
- 日本獣医臨床病理学会
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- トリプターゼ・PAR-2経路によるアナフィラキシー発症機構の解明 2015 研究活動スタート支援