1. 2021
  2. 2020
  3. 2019
  4. 2018
  5. 2017
  6. 2016
  7. 2015
  8. 2014
  9. 2013
  10. 2012
  11. 2011
  12. 2010
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  20. 2002


Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R. (2021)
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
J. Biol. Chem. 297, 100989.
[PubMed] [研究成果]

Takahashi Y, Inoue Y, Kuze K, Sato S, Shimizu M, Kiyono H, Yamauchi Y, Sato R.(2021)
Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids.
Biosci Biotechnol Biochem.

Sasaki T, Watanabe Y, Kuboyama A, Oikawa A, Shimizu M, Yamauchi Y, Sato R. (2021)
Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice.
J. Biol. Chem. 296, 100131.
[PubMed] [研究成果]

山内祥生、佐々木崇、佐藤隆一郎 (2021) ステロール代謝と骨格筋機能:医・食・薬からの統合的知見 生化学 93, 930015.


Chikazawa M, Morikawa Y, Uramoto M, Yamauchi Y, Shimizu M, Shimizu K, Sato R. (2020)
Functional effect of nobiletin as a food-derived allosteric modulator of mouse CRFR2β in skeletal muscle
Biochem Biophys Res Commun. 529, 328-334.

Sato R. (2020)
Recent advances in regulating cholesterol and bile acid metabolism.
Biosci Biotechnol Biochem. 522, 113-120.

Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R. (2020)
Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
J. Biol. Chem. 295, 3918-3928.
[PubMed] [研究成果]

Chikazawa M, Shimizu M, Yamauchi Y, Sato R. (2020)
Bridging molecules are secreted from the skeletal muscle and potentially regulate muscle differentiation.
Biochem Biophys Res Commun. 522, 113-120.

Sato R. (2020)
Homeosatasis of skeletal muscle function and a functional food ingredient:Citrus limonoid nomilin.
Glycatvie Stress Research 7, 110-115.

佐々木崇、佐藤隆一郎 (2020) 加齢による骨格筋機能低下のメカニズム 運動機能・認知機能改善食品の開発 23-30.

佐藤隆一郎 (2020) 摂食シグナルを受容する胆汁酸受容体TGR5 実験医学 38, 132-137.

高橋裕、佐藤慎太郎、佐藤隆一郎 (2020) iPS細胞を活用した生理機能の高いヒトモデルの構築とその応用 実験医学 38, 224-230.


Iwase M, Watanabe K, Shimizu M, Suzuki T, Yamamoto Y, Inoue J, Sato R. (2019)
Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins.
Biosci Biotechnol Biochem. 83, 1740-1746.

佐藤隆一郎 (2019) 摂食シグナル胆汁酸を感知する受容体TGR5による骨格筋機能維持機構 臨床栄養 134, 596-600.

佐藤隆一郎 (2019) オキシステロール代謝と疾患制御 医学のあゆみ 269, 1181-1186.

佐藤隆一郎 (2019) 健康寿命延伸をもたらす運動機能性食品の開発展望 ソフト・ドリンク技術資料 188, 91-103.(201-213)

佐藤隆一郎 (2019) 健康寿命延伸をもたらす運動機能を模倣する機能性食品 FOOD STYLE 21 23, 49-51.

佐々木崇・佐藤隆一郎 (2019) 骨格筋の脂質代謝メカニズム 筋肉研究最前線 89-96.


Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi K, Ogawa H, Shima Y, Wang L, Sato R, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi KI, (2018)
Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Commun Biol. 1, 18. [PubMed]

Yamauchi Y, Rogers MA. (2018)
Sterol Metabolism and Transport in Atherosclerosis and Cancer.
Front Endocrinol. 9, 509. [PubMed]


Aoki H, Hanayama M, Mori K, Sato R. (2018)
Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice.
Biosci Biotechnol Biochem. 82, 1550-1559.

Chikazawa M, Sato R. (2018)
Identification of a novel function of resveratrol and genistein as a regulator of β2 -adrenergic receptor expression in skeletal muscle cells and characterization of promoter elements required for promoter activation.
Mol Nutr Food Res. 62, e1800530.

Inoue J, Miyata S, Shimizu M, Sato R. (2018)
Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins.
Biosci Biotechnol Biochem. 82, 1591-1598.

Kuboyama A, Sasaki T, Shimizu M, Inoue J, Sato R. (2018)
The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress.
Biosci Biotechnol Biochem. 82, 1377-1383.

Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R. (2018)
The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice.
J. Biol. Chem. 293, 10322-10332.
[PubMed] [研究成果]

Maruyama R, Shimizu M, Hashidume T, Inoue J, Itoh N, Sato R. (2018)
FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions.
J Nutr Sci Vitaminol (Tokyo). 64, 200-208.

Chikazawa, M., Sato, R. (2018)
Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle.
J Nutr Sci Vitaminol (Tokyo). 64, 68-74.

佐藤隆一郎 (2018) 分子細胞生物学研究から疾病発症予防に資する機能性食品成分探索 バイオサイエンスとインダストリー 76, 208-212.

佐藤隆一郎 (2018) 健康寿命延伸をもたらす運動機能性食品の開発展望 食品と開発 53, No.10 4-7.


Chang TY, Yamauchi Y, Hasan MT, Chang C.(2017)
Cellular cholesterol homeostasis and Alzheimer's disease.
J Lipid Res. 58, 2239-2254.

Yamauchi Y, Yokoyama S, Chang TY.(2017)
Methods for monitoring ABCA1-dependent sterol release.
Methods Mol Biol. 1583, 257-273.

Shimano, H., Sato, R. (2017)
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
Nature Rev. Endocrinol. 13, 710-730.

Sasaki, T., Mita, M., Ikari, N., Kuboyama, A., Hashimoto, S., Kaneko, T., Ishiguro, M., Shimizu, M., Inoue, J., and Sato, R. (2017)
Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.
PLoS ONE 12, e0179226.

Inoue, J., Ikeda, S., Kanayama, T., and Sato, R. (2017)
The flavonoid derivative 4'-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK.
Biosci. Biotechnol. Biochem. 81, 1548-1552

Kuan, Y-C., Hashidume, T., Shibata, T., Uchida, K., Shimizu, M., Inoue, J., and Sato, R. (2017)
Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-Binding Protein (SREBP) and SREBP Cleavage-Activating Protein.
J. Biol. Chem. 292, 3106-3028.
[PubMed] [研究成果]

Inoue, J., Ihara, Y., Tsukamoto, D., Yasumoto, K., Hashidume, T., Kamimura, K., Hirano, S., Shimizu, M., Kominami, R., and Sato, R. (2017)
BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice.
Biosci. Biotechnol. Biochem. 81, 922-930.

佐藤隆一郎 (2017) 運動によるAMPキナーゼ活性化と転写制御による代謝改善効果 非栄養素の分子栄養学 第11章 建帛社 170-183

佐藤隆一郎 (2017) ロコモーション機能向上に寄与する食品の開発  生物工学会誌 95, 252-253

佐藤隆一郎 (2017) 柑橘成分による胆汁酸受容体TGR5活性化による健康寿命の延伸 食品機械装置 54, 50-55

清水誠 (2017) 抗肥満ホルモンFGF21の転写制御と機能性食品成分 非栄養素の分子栄養学 第8章 建帛社 123-129


Yamauchi Y, Yokoyama S, Chang TY. (2016)
ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis.
J Lipid Res. 57, 77-88.

Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M.(2016)
Raft-based interactions of gangliosides with a GPI-anchored receptor.
Nature Chem Biol. 12, 402-410.

Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K. (2016)
Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.
Sci Rep. 6, 34505.

Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K. (2016)
Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.
Int J Oncol. 49, 1369-1376.

Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K. (2016)
Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.
Glycobiology. 26, 984-998.

Inoue, J., Ihara, Y., Tsukamoto, D., Yasumoto, K., Hashidume, T., Kamimura, K., Nakai, Y., Hirano, S., Shimizu, M., Kominami, R., and Sato, R. (2016)
Identification of BCL11B as a regulator of adipogenesis.
Sci. Rep. 6, 32750.

Hashidume, T., Kato, A., Tanaka, T., Miyoshi, S., Itoh, N., Nakata, R., Inoue, H., Oikawa, A., Nakai, Y., Shimizu, M., Inoue, J., and Sato, R. (2016)
Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.
Sci. Rep. 6, 28183.
[PubMed] [研究成果][UTokyo Research]

Ochiai, A., Miyata, S., Iwase, M., Shimizu, M., Inoue, J., and Sato, R. (2016)
Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes.
Sci. Rep. 6, 24940.

Maruyama, R., Shimizu, M., Li, J., Inoue, J., and Sato, R. (2016)
Fibroblast growth factor 21 induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region.
Biosci. Biotechnol. Biochem. 80, 929-934.

Maruyama, R., Shimizu, M., Ishijima, T., Nakai, Y., Inoue, J., and Sato, R. (2016)
Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
Biosci. Biotechnol. Biochem. 80, 1149-1154.

Takahashi, Y., Shinoda, A., Kamada, H., Shimizu, M., Inoue, J., and Sato, R. (2016)
Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation.
Sci. Rep. 6, 20975.

Miyata, S., Inoue, J., Shimizu, M., and Sato, R. (2016)
Allyl isothiocyanate suppresses the proteolytic activation of sterol regulatory element-binding proteins and de novo fatty acid and cholesterol synthesis.
Biosci. Biotechnol. Biochem. 80, 1006-1011.

佐藤隆一郎 (2016) フラボノイド類の脂質代謝改善効果の分指標的解析 日本ポリフェノール学会雑誌 5,34-437

佐藤隆一郎 (2016) 胆汁酸受容体TGR5活性化による健康寿命の延伸 脂質栄養学 25,35-42

井上順、佐藤隆一郎 (2016) フラボノイド「ルテオリン」による生活習慣病予防・改善作用の分子機構 化学と生物 6, 416-421[リンク]

佐藤隆一郎 (2016) “ノウゲイ・カガク・カ”讃歌 化学と生物 54, 299

佐藤隆一郎 (2016) 「食べることが動くことに」食品が代替できる運動機能の可能性 実験医学 34, 2196-219

佐藤隆一郎 (2016) コレステロールによる遺伝子発現制御 実験医学 34, 2462-2467

佐藤隆一郎 (2016) 抗肥満・代謝改善効果を有する機能性食品成分 Food Style 21 Vol 20, 44-48


Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S. (2015)
Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum.
J Biol Chem. 290, 23464-77. "Selected as a Paper of the Week"

Ochiai, A., Miyata, S., Shimizu, M., Inoue, J., and Sato, R. (2015)
Piperine induces hepatic low-density lipoprotein receptor expression through proteolytic activation of sterol regulatory element-binding proteins.
PLoS ONE 10, e0139799.

Li, J., Inoue, J., Choi J.M., Nakamura, S., Yan, Z., Fushinobu, S., Kamada, H., Kato, H., Hashidume, T., Shimizu, M., and Sato, R. (2015)
Identification of the flavonoid luteolin as a repressor of the transcription factor hepatocyte nuclear factor 4α.
J. Biol. Chem. 290, 24021-24035.
[PubMed] [研究成果]

Takashima, K., Saitoh, A., Funabashi, T., Hirose, S., Yagi, C., Nozaki, S., Sato, R., Shin, H.W., and Nakayama, K. (2015)
COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.
J. Cell Sci. 128, 2805-2815.
[PubMed] [研究成果]

Miyata, S., Inoue, J., Shimizu, M., and Sato, R. (2015)
Xanthohumol improves diet-induced obesity and fatty liver by suppressing sterol regulatory element-binding protein (SREBP) activation.
J. Biol. Chem. 290, 20565-20579.
[PubMed] [研究成果]

Shimizu, M., Li, J., Inoue, J., and Sato, R. (2015)
Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ.
PLoS ONE 10, e0121784.
[PubMed] [研究成果]

Shimizu, M., Morimoto, H., Maruyama, R., Inoue, J., and Sato, R.(2015)
Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress.
J. Nutr. Sci. Vitaminol. (Tokyo) 61,154-160.

Horiba, T., Katsukawa, M., Mita, M., and Sato, R.(2015)
Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway.
Biochem. Biophys. Res. Commun. 463,846-852.

Sato, R. (2015)
Functions of Cholesterol Metabolites.
J. Nutr. Sci. Vitaminol. (Tokyo) 61, S151-S15.

佐藤隆一郎 (2015) 脂質合成系調節転写因子SREBP The Lipid 26, 283-287

佐藤隆一郎 (2015) 胆汁酸受容体TGR5を標的とした抗肥満・血糖効果作用をもつ機能性食品成分 食品因子による栄養機能制御 建帛社 72-82

井上順 (2015) ポリフェノール類による転写制御を介した代謝改善効果 食品因子による栄養機能制御 建帛社 161-176


Sasaki, T., Nakata, R., Inoue, H., Shimizu, M., Inoue, J., and Sato, R. (2014)
Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle.
Am. J. Physiol. Endocrinol.Metab. 306, E1085-E1092.
[PubMed] [研究成果]

Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S. (2014)
Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.
PLoS ONE 9, e107492.

清水誠、井上順、佐藤隆一郎 (2014) グルタミンによる細胞維持・増殖調整機構 <最新>動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術 63-66

佐藤隆一郎 (2014) コレステロール代謝調節研究 特集にあたって バイオインダストリー 31, 3-4

井上順、佐藤隆一郎 (2014) コレステロール合成・代謝・恒常性維持 バイオインダストリー 31, 5-10

佐藤隆一郎 (2014) 脂質代謝とグルタミン 生化学 86, 360-366

井上順 (2014) 栄養科学イラストレイテッド 分子栄養学 羊土社 分担執筆


Fujiki, K., Shinoda, A., Kano, F., Sato, R., Shirahige, K., and Murata, M. (2013)
PPARγ-Induced PARylation Promotes Local DNA Demethylation by Production of 5-Hydroxymethylcytosine.
Nature Communications 4, 2262.

Maruyama, R., Kamoshida, Y, Shimizu, M., Inoue, J., and Sato, R. (2013)
ATF6α stimulates cholesterogenic gene expression and de novo cholesterol synthesis.
Biosci. Biotechnol. Biochem. 77, 1734-1738.

Takahashi, Y., Shinoda, A., Furuya, N., Harada, E., Arimura, N., Ichi, I., Fujiwara, Y., Inoue, J., and Sato, R. (2013)
Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation.
PLoS ONE 8, e64605.

Shimizu, M., Li, J., Maruyama, R., Inoue, J., and Sato, R. (2013)
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress.
Biochem. J. 450, 221-229.

Yashiro, T., Nanmoku, M., Shimizu, M., Inoue, J., and Sato, R. (2013)
5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element.
Atherosclerosis 226, 95-101.

Inoue, J. and Sato, R.
New insights into the activation of sterol regulatory element-binding proteins by proteolytic processing.
Biomol. Concepts 4, 417-423.

Sato, R. (2013)
Nomilin as an anti-obesity and anti-hyperglycemic agent.
Vitam. Horm. 91, 425-439.


Fujino, T., Takeuchi, A., Maruko-Ohtake, A., Ohtake, Y., Satoh, J., Kobayashi, T., Tanaka, T., Ito, H., Sakamaki, R., Kashimura, R., Ando, K., Nishimaki-Mogami, T., Ohkubo, Y., Kitamura, N., Sato, R., Kikugawa, K., and Hayakawa, M. (2012)
Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell proliferation.
J. Biochem. 152, 577-586.

Miyata, S., Inoue, J., Shimizu, M., and Sato, R. (2012)
4′-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis.
FEBS Lett. 586, 1778-1782.

Yashiro, T., Nanmoku, M., Shimizu, M., Inoue, J., and Sato, R. (2012)
Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins.
Atherosclerosis 220, 369-374.

Ohoka, N., Okuhira, K., Cui, H., Wu, W., Sato, R., Naito, M., and Nishimaki-Mogami, T. (2012)
HNF4α Increases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion
Arterioscler. Thromb. Vasc. Biol. 32, 1005-1014.

佐藤隆一郎(2012)胆汁酸による脂質エネルギー代謝 The Lipid 23, 40-45

佐藤隆一郎(2012)柑橘成分ノミリンは胆汁酸受容体を介して血糖低下、抗肥満効果を発揮する バイオサイエンスとインダストリー 70, 128-132

佐藤隆一郎(2012)私のメンター Joseph L. Goldstein/Michael S. Brown 実験医学 30, 994-998


Ono, E., Inoue, J., Hashidume, T., Shimizu, M., and Sato, R. (2011)
Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet.
Biochem. Biophys. Res. Commun. 410, 677-681.

Hashidume, T., Sasaki, T., Inoue, J., and Sato, R. (2011)
Consumption of soy protein isolate reduces hepatic SREBP-1c and lipogenic gene expression in wild-type mice, but not in FXR-deficient mice.
Biosci. Biotechnol. Biochem. 75, 1702-1707.
2011年 B.B.B.論文賞

Inoue, J., Ito, Y., Shimada, S., Satoh, S., Sasaki, T., Hashidume, T., Kamoshida, Y., Shimizu, M., and Sato, R. (2011)
Glutamine stimulates the gene expression and processing of sterol regulatory element-binding proteins, thereby increasing the expression of their target genes.
FEBS J. 278, 2739-2750.

Yashiro, T., Yokoi, Y., Shimizu, M., Inoue, J., and Sato, R. (2011)
Chenodeoxycholic acid stabilization of LDL receptor mRNA depends on 3'-untranslated region and AU-rich element-binding protein.
Biochem. Biophys. Res. Commun. 409, 155-159.

Inoue, J., Yamasaki, K., Ikeuchi, E., Satoh, S., Fujiwara, Y., Nishimaki-Mogami, T., Shimizu, M., and Sato, R. (2011)
Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Mol. Endocrinol. 25, 995-1005.

Hatori, M., Hirota, T., Iitsuka, M., Kurabayashi, N., Haraguchi, S., Kokame, K., Sato, R., Nakai, A., Miyata, T., Tsutsui, K., and Fukada, Y. (2011)
Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways.
Proc. Natl. Acad. Sci. U S A. 108, 4864-4869.

Inoue, J., Tanaka, M. Nanmoku, M., Yashiro, T., and Sato, R. (2011)
Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes.
Mol. Nutr. Food Res. 55, 1052-1058.

Hiramatsu Y, Hosono A, Konno T, Nakanishi Y, Muto M, Suyama A, Hachimura S, Sato R, Takahashi K, and Kaminogawa S. (2011)
Orally administered Bifidobacterium triggers immune responses following capture by CD11c(+) cells in Peyer's patches and cecal patches.
Cytotechnology 63, 307-317.

井上順、佐藤隆一郎(2011)グルタミンはSREBP活性化を介して細胞増殖亢進に寄与する バイオサイエンスとインダストリー 69, 488-490

佐藤隆一郎(2011)AMPキナーゼによる脂質代謝制御 内分泌・糖尿病・代謝内科 33, 93-98

井上順(2011)コレステロール恒常性に関する分子栄養生化学的研究 日本栄養・食糧学会誌 第64巻 第5号, 297-303

佐藤隆一郎(2011)ケルセチンと脂質代謝 Functional Food 5, 144-148


Inoue, J., Choi, J.M., Yoshidomi, T., Yashiro, T., and Sato, R. (2010)
Quercetin enhances VDR activity, leading to stimulation of its target gene expression in Caco-2 cells
J. Nutr. Sci. Vitaminol. (Tokyo). 56, 326-330.

Takahashi, Y., Shinoda, A., Inoue, J., and Sato, R. (2010)
The gene expression of the myocardial lipid droplet protein is highly regulated by PPARgamma in adipocytes differentiated from MEFs or SVCs.
Biochem. Biophys. Res. Commun. 399, 209-214.

Sato, R. (2010)
Sterol metabolism and SREBP activation.
Arch. Biochem. Biophys. 501, 177-181.

Horiba, T., Nishimura, I., Nakai, Y., Abe, K., and Sato, R. (2010)
Naringenin chalcone improves adipocyte functions by enhancing adiponectin production.
Mol. Cell. Endocrinol. 323, 208-214.

佐藤隆一郎(2010)メタボリックシンドロームとは 腸内細菌学雑誌 24, 203-209

佐藤隆一郎(2010)食の安全科学の展開―食のリスク予測と制御に向けてー 152-157 シーエムシー出版

佐藤隆一郎(2010)見直されたレジン(陰イオン交換樹脂)−その位置づけと使い方― 22-27 フジメディカル出版


Irisawa, M., Inoue, J., Ozawa, N., Mori, K. and Sato, R. (2009)
The sterol-sensing ER membrane protein TRC8 hampers ER-to-Golgi transport of SREBP-2/SCAP and reduces SREBP-2 cleavage.
J. Biol. Chem. 284, 28995-29004.

Ohoka, N., Kato, S., Takahashi, Y., Hayashi, H. and Sato, R. (2009)
The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.
Mol. Endocrinol. 23, 759-771.

Sato, R. (2009)
SREBPs: protein interaction and SREBPs.
FEBS J. 276, 622-627. Review.

Nishizuka, M., Kishimoto, K., Kato, A., Ikawa, M., Okabe, M., Sato, R., Niida, H., Nakanishi, M., Osada, S. and Imagawa, M. (2009)
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.
Exp. Cell Res. 315, 809-819.

Takahashi, Y., Inoue, J., Kagechika, H. and Sato, R. (2009)
ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists.
FEBS Lett. 583, 493-497.

Shiokawa A., Tanabe K., Tsuji N.M., Sato R. and Hachimura S. (2009)
IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance.
Immunol. Lett. 125, 7-14.

佐藤隆一郎 (2009) 脂質代謝調節の中心的役割を担う転写因子SREBPs 生体の科学 60, 605-610

佐藤隆一郎 (2009) 胆汁酸の脂質代謝調節作用と臨床応用 The Lipid Vol.20 No.1 82-86

佐藤隆一郎 (2009) スタチンとHDLコレステロール"コレステロール−基礎から臨床へ-" ライフサイエンス出版 分担執筆


Takahashi, M., Kanayama, T., Yashiro, T., Kondo, H., Murase, T., Hase, T., Tokimitsu, I., Nishikawa J. and Sato, R. (2008)
Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligand.
Biochem. Biophys. Res. Commun. 372, 395-399.

Inoue, J., Satoh, S., Kita, M., Nakahara, M., Hachimura, S., Miyata, M., Nishimaki-Mogami, T. and Sato, R. (2008)
PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.
Biochem. Biophys. Res. Commun. 371, 675-678.

Arito, M., Horiba, T., Hachimura, S., Inoue, J. and Sato, R. (2008)
Growth factor-induced phosphorylation of srebps inhibits sumoylation, thereby stimulating the expression of their target genes, LDL uptake and lipid synthesis.
J. Biol. Chem. 283, 15224-15231.

Takahashi, Y., Ohoka, N., Hayashi, H. and Sato, R. (2008)
TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity.
J. Lipid. Res. 49, 880-892.

Tsuge, T., Uetani, K., Sato, R., Ohashi-Kobayashi, A. and Maeda, M. (2008)
Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane.
Cell. Biol. Int. 32, 298-303.

高野達哉、板部洋之、森雅博、木村順治、中神啓仁、佐藤隆一郎、橋田亮一、柳生靖子、峰尾千恵子、天沼喜美子、今中常雄、東祐輔、藤本康之、藤田永子 (2008) 動脈硬化におけるCholesterolの蓄積:粥腫形成・進展機構の分子病理学的解析 YAKUGAKU ZASSHI Vol.128 No.10 1383-1401      

井上順、有戸光美、佐藤隆一郎 (2008) SREBPの翻訳後修飾ーリン酸化、ユビキチン化、アセチル化、SUMO化ー 内分泌・糖尿病科 Vol.27 No.6 552-557



Nakakuki, M., Shimano, H., Inoue, N., Tamura, M., Matsuzaka, T., Nakagawa, Y., Yahagi, N., Toyoshima, H., Sato, R. and Yamada, N. (2007)
A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.
FEBS J. 274, 4440-4452.

Kanayama, T., Arito, M., So, K., Hachimura, S., Inoue, J. and Sato, R. (2007)
Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities.
J. Biol. Chem. 282, 10290-10298.

Tamehiro, N., Shigemoto-Mogami, Y., Kakeya, T., Okuhira, K., Suzuki, K., Sato, R., Nagao, T. and Nishimaki-Mogami, T. (2007)
Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.
J. Biol. Chem. 282, 21090-21099

Tachibana, S., Hirano, M., Hirata, T., Matsuo, M., Ikeda, I., Ueda, K. and Sato, R. (2007)
Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.
Biosci Biotechnol Biochem. 71, 1886-1895. (2007年度BBB論文賞受賞)

Takahashi, N., Morita, M., Maeda, T., Harayama, Y., Shimozawa, N., Suzuki, Y., Furuya, H., Sato, R., Kashiwayama, Y. and Imanaka, T. (2007)
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
J. Neurochem. 101, 1632-1643.

Takano, Y., Matsuura, T., Yoshikawa, Y., Satsu, H., Sato, R. and Shimizu, M. (2007)
Modulation of the intestinal Ca2+ uptake by a cheese whey protein digest.
Biosci Biotechnol Biochem. 71, 1487-1493.

佐藤隆一郎 (2007) スタチンによるHDL-C上昇メカニズム  PROGRESS IN MEDICINE VoL27 No.12 2857-2862

佐藤隆一郎 (2007) 転写因子 機能性食品の事典(朝倉書店) 359-362

佐藤隆一郎 (2007) “一枚の写真館“ 核で働く転写因子が小胞体膜タンパク質? 細胞工学 Vol.26 No.10 1109

佐藤隆一郎 (2007) 核内受容体による脂質代謝制御と食品機能成分 Functional FoodVol.1 No.1 48-53

佐藤隆一郎 (2007) 脂肪細胞肥大と脂肪滴形成:ペリリピンの機能 The Lipid Vol.18No.4 73-76

佐藤隆一郎 (2007) 食品機能による生活習慣病予防 FFIジャ−ナルVol.212 No.3227-232  

佐藤隆一郎 (2007) ブックレビュー 岩波科学ライブラリー 新薬スタチンの発見 蛋白質核酸酵素 第52巻 第1号 95


Nadanaka, S., Yoshida, H., Sato, R. and Mori, K. (2006)
Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells.
Cell Struc. Func. 31, 109-116.

Yoshida, H., Nadanaka, S., Sato, R. and Mori, K. (2006)
XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells.
Cell Struc. Funct. 31, 117-125.

Shimizu, M., Akter, M.H., Emi, Y., Sato, R., Yamaguchi, T., Hirose, F. and Osumi, T. (2006)
Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective transactivation of the perilipin/PEX11 alpha gene pair.
J Biochem. (Tokyo) 139, 563-573.

Iwamoto, N., Abe-Dohmae, S., Sato, R. and Yokoyama, S. (2006)
ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis.
J. Lipid Res. 47, 1915-1927.

Inoue, J., Kanefuji, T., Okazuka, K., Watanabe, H., Mishima, Y. and Kominami, R. (2006)
Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice.
J. Immunol. 176: 5871-5879.

Ryuichiro Sato (Contributor) (2006) Dietary Fats and Risk of Chronic Disease A Publication of AOCS Press

金山知彦、西川純一、佐藤隆一郎 (2006) 核内受容体リガンド評価系の創薬・食品開発研究への応用 バイオサイエンスとバイオインダストリーVol.64 No.7, 17-20

古屋徳彦、佐藤隆一郎 (2006) 胆汁酸の新たな生理機能と脂質代謝調節 化学と生物 第44巻 第11号 516号


Nakahara, M., Furuya, N., Takagaki, K., Sugaya, T., Hirota, K., Fukamizu, A., Kanda, T., Fujii, H. and Sato, R. (2005)
Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine..
J. Biol. Chem. 280, 42283-42289.

Inoue, N., Shimano, H., Nakakuki, M., Matsuzaka, T., Nakagawa, Y., Yamamoto, T., Sato, R., Takahashi, A., Sone, H., Yahagi, N., Suzuki, H., Toyoshima, H. and Yamada, N. (2005)
Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor.
Mol. Cell Biol. 25, 8938-8947.

Qiu, W., Taghibiglou, C., Avramoglu, R. K., Van Iderstine, S, C., Naples, M., Ashrafpour, H., Mhapsekar, S., Sato, R. and Adeli, K. (2005)
Oleate-mediated stimulation of microsomal triglyceride transfer protein (MTP) gene promoter: implications for hepatic MTP overexpression in insulin resistance.
Biochemistry. 44, 3041-3049.

Hirao, T., Imai, S., Sawada, H., Shiomi, N., Hachimura, S. and Kato, H. (2005)
PCR method for detecting trace amounts of buckwheat (Fagopyrum spp.) in food.
Biosci Biotechnol Biochem. 69, 724-731.

Okazuka, K., Wakabayashi, Y., Kashihara, M., Inoue, J., Sato, T., Yokoyama, M., Aizawa, S., Aizawa, Y., Mishima, Y. and Kominami, R. (2005)
p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl11b-/-mice.
Biochem. Biophys. Res. Commun. 328, 545-549.

Arlotta, P., Molyneaux, B. J., Chen, J., Inoue, J., Kominami, R. and Macklis, J. D. (2005)
Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
Neuron. 45, 207-221.

佐藤隆一郎 (2005) コレステロール代謝の調節、摂取する脂質の量と質の調査、ほかの栄養素との関係 エッセンシャル基礎栄養学66-80 医歯薬出版(株)

佐藤隆一郎 (2005) 脂質の代謝調節と遺伝子発現 脂質栄養と健康 92-102 建帛社


Hirokane, H., Nakahara, M., Tachibana, S., Shimizu, M. and Sato, R. (2004)
Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.
J Biol Chem. 279, 45685-45692

Arimura, N., Horiba, T., Imagawa, M., Shimizu, M. and Sato, R. (2004)
The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes.
J Biol Chem. 279, 10070-10076

Yamamoto, T., Shimano, H., Nakagawa, Y., Ide, T., Yahagi, N., Matsuzaka, T., Nakakuki, M., Takahashi, A., Suzuki, H., Sone, H., Toyoshima, H., Sato, R. and Yamada, N. (2004)
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
J Biol Chem. 279, 12027-12035

佐藤隆一郎 (2004) 胆汁酸の生理機能 機能性脂質のフロンティア155-159 シーエムシー出版

平野祐子、佐藤隆一郎 (2004) 膜貫切断の新展開 実験医学 22, 243-249.

佐藤隆一郎、酒井寿郎 (2004) コレステロールホメオスタシスを担う転写因子SREBP 生化学 76, 503-508.

佐藤隆一郎 (2004) 脂質代謝制御の分子基盤 化学と生物 42, 300-308.

佐藤隆一郎 (2004) 脂質代謝を制御する転写因子SREBPの翻訳後修飾による機能調節 日本農芸化学会誌 78, 45-47


Misawa, K., Horiba, T., Arimura, N., Hirano, Y., Inoue., J, Emoto., N, Shimano., H, Shimizu, M. and Sato, R. (2003)
Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.
J Biol Chem. 278, 36176-36185.

Okada, T., Haze, K., Nadanaka, S., Yoshida, H., Seidah, N., G. Hirano, Y., Sato, R., Negishi, M. and Mori, K. (2003)
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.
J Biol Chem. 278, 31024-31022.

Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., Sekiya, M., Takahashi, A., Hasty, AH., Sato, R., Sone, H., Osuga, J., Ishibashi, S. and Yamada N. (2003)
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Mol Endocrinol. 17, 1240-1254.

Hirano, Y., Murata, S., Tanaka, K., Shimizu, M. and Sato, R. (2003)
Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway.
J Biol Chem. 278, 16809-16819.

Natsume, Y., Satsu, H., Hatsugai, Y., Watanabe, H., Sato, R., Ashida, H., Tukey, R.H. and Shimizu, M. (2003)
Evaluation of intestinal dioxin permeability using human Caco-2 cell monolayers.
Food Sci.Technol.Res. 9, 364-366.

Takano, Y., Sato, R., Satsu, H. and Shimizu, M. (2003)
Characterization of the human intestinal calcium transporter, CaT1, stably expressed CHO cells.
Cytotechnol.43, 113-120

佐藤隆一郎 (2003) マッキー生化学 分担翻訳 化学同人

佐藤隆一郎 (2003) 高脂血症の分子栄養学と治療・予防 臨床栄養 103, 559-564.

佐藤隆一郎 (2003) コレステロール代謝調節の分子機構と動脈硬化 日本栄養・食糧学会誌 56, 127-133.

佐藤隆一郎 (2003) 遺伝子発現制御を介した脂質代謝の分子基盤 脂質栄養学 12, 35-43.

中原真裕子、佐藤隆一郎 (2003) 胆汁酸の新たな生理機能による脂質代謝制御 バイオサイエンスとインダストリー 61, 479-480.


Tanaka, Y., Ueda, K., Ozawa, T., Sakuragawa, N., Yokota, S., Sato, R., Okamura, S., Morita, M., and Imanaka, T. (2002)
Intracellular accumulation of antithrombin Morioka (C95R), a novel mutation causing type I antithrombin deficiency.
J Biol Chem. 277, 51058-51067.

Nakahara, M., Fujii, H., Maloney, P.R., Shimizu, M. and Sato, R. (2002)
Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA.
J Biol Chem. 277, 37229-37234.

Ito, J., Nagayasu, Y., Kato, K., Sato, R. and Yokoyama, S. (2002)
Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes.
J Biol Chem.
277, 7929-7935.

Amemiya-Kudo, M., Shimano, H., Hasty, A. H., Yahagi, N., Yoshikawa, T., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S. and Yamada, N. (2002)
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
J Lipid Res.

Higashi, Y., Itabe, H., Fukase, H., Mori, M., Fujimoto, Y., Sato, R., Imanaka, T. and Takano, T. (2002)
Distribution of microsomal triglyceride transfer protein within sub-endoplasmic reticulum regions in human hepatoma cells.
1581, 127-36.

Ishizuka, K., Miyamoto, Y., Satsu, H., Sato, R. and Shimizu, M. (2002)
Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells.
Biosci.Biotechnol.Biochem. 66, 730-736.

佐藤隆一郎 (2002) 脂質代謝の分子生物学 分子栄養学 32-42. 光生館

佐藤隆一郎 (2002) バイオテクノロジーとノーベル賞 バイオサイエンスとインダストリー 60, 606.

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