Publications

Original Papers

  1. The Tetrafluoroethylene-Mediated Ring-Closing Metathesis: Enabling Unfavored Reactions
    Akiyama, M.; Amabe, Y.; Sugiyama, M.; Sugiyama, K.; Gatzenmeier, T.; Okazoe, T.
    J. Am. Chem. Soc., 146, 32550−32557 (2024).
  2. Synthesis of bisphenol-A- and bio-based polyarylates via amorphous solid-state polymerization with fluoroalkyl diesters
    Taniguchi, T.; Okazoe, T.; Matsuoka, S.; Suzuki, M.
    Chem. Lett., 53, upae213 (2024).
  3. Exceptionally Short Tetracoordinated Carbon–Halogen Bonds in Hexafluorodihalocubanes
    Sugiyama, M.; Uetake, Y.; Miyagi, N.; Yoshida, M.; Nozaki, K.; Okazoe, T.; Akiyama, M.
    J. Am. Chem. Soc., 146, 30686–30697 (2024).
  4. Highly Alternating Copolymer of [1.1.1]Propellane and Perfluoro Vinyl Ether: Forming a Hydrophobic and Oleophobic Surface with <50% Fluorine Monomer Content
    Okuda, M.; Akiyama, M.; Funahashi, K.; Masuda, J.; Kohata, A.; Nakagawa, S.; Kashiwagi, K.; Sugiyama, N.; Okazoe, T.; Kawaguchi, D.
    ACS Macro Lett., 13, 1383–1389 (2024).
  5. Pd-Catalyzed Thiotritylation Cross-Coupling of Aryl Bromides and Iodides to Access Sulfur Functional Groups
    Liu, Y.; Okazoe, T.; Gatzenmeier, T.; Nozaki, K.
    ChemistryEurope, e202400053 (2024).
  6. Fluoro-Crown Ether Phosphate as Efficient Cell-Permeable Drug Carrier by Disrupting Hydration Layer
    Goswami, A.; Kohata, A.; Okazoe, T.; Huang, H.; Aida, T.
    J. Am. Chem. Soc., 146, 23406–23411 (2024).
  7. Fluorocarbon–DNA conjugates for enhanced cellular delivery: Formation of a densely packed DNA nano-assembly
    Narita, M.; Kohata, A.; Kageyama, T.; Watanabe, H.; Aikawa, K.; Kawaguchi, D.; Morihiro, K.; Okamoto, A.; Okazoe, T.
    ChemBioChem, e202400436 (2024).
  8. Photo-on-Demand In Situ One-Pot Synthesis of Carbonate Esters from Tetrachloroethylene
    Higashimura, I.; Shele, M.; Akamatsu, T.; Ohmura, R.; Liang, F.; Okazoe, T.; Tsuda, A.
    J. Org. Chem., 89, 1864–1872 (2024).
  9. Fluorine-driven amorphous solid-state polycondensation: phosgene-free synthesis of high-molecular weight polycarbonate from fluorinated carbona
    Taniguchi, T.; Shirota, N.; Okazoe, T.; Matsuoka, S.; Yamamoto, K.; Suzuki, M.
    Polym. Chem., 15, 508–515 (2024).
  10. Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery
    Takatsu, M.; Morihiro, K.; Watanabe, H.; Yuki, M.; Hattori, T.; Noi, K.; Aikawa, K.; Noguchi, K.; Yohda, M.; Okazoe, T.; Okamoto, A.
    ACS Chem. Biol., 18, 2590–2598 (2023).
  11. Fluoroalkylated Hypervalent Sulfur Fluorides: Radical Addition of Arylchlorotetrafluoro-λ6-sulfanes to Tetrafluoroethylene
    Yasuo, E.; Aikawa, K.; Nozaki, K.; Okazoe, T.
    Chem. Sci., 14, 12379–12385 (2023).
  12. Difluorination of Heterobenzylic C–H Bonds with N-Fluoro-N-(fluorosulfonyl)carbamate (NFC)
    Adachi, A.; Hashimoto, T.; Aikawa, K.; Nozaki, K.; Okazoe, T.
    Org. Chem. Front., 10, 5362–5368 (2023).
  13. Non-Isocyanate Polyurethane Synthesis by Polycondensation of Alkylene and Arylene Bis(fluoroalkyl) Bis(carbonate)s with Diamines
    Hosokawa, S.; Nagao, A.; Hashimoto, Y.; Matsune, A.; Okazoe, T.; Suzuki, C.; Wada, H.; Kakiuchi, T.; Tsuda, A.
    Bull. Chem. Soc. Jpn., 96, 663–670 (2023).
  14. Synthesis of Short Peptides with Perfluoroalkyl Side Chains and Evaluation of Their Cellular Uptake Efficiency
    Kadota, K.; Mikami, T.; Kohata, A.; Morimoto, J.; Sando, S.; Aikawa, K.; Okazoe, T.
    ChemBioChem, e202300374 (2023).
  15. N-Fluorobenzenesulfonimide (NFSI) analogs with deprotectable substituents: Synthesis of β-fluoroamines via catalytic aminofluorination of styrenes
    Ito, Y.; Adachi, A.; Aikawa, K.*; Nozaki, K.; Okazoe, T.
    Chem. Commun., 59, 9195–9198 (2023).
  16. The Fluorocarbene Exploit: Enforcing Alternation in Ring-Opening Metathesis Polymerization
    Tashiro, K.; Akiyama, M.; Kashiwagi, K.; Okazoe, T.
    J. Am. Chem. Soc., 145, 2941–2950 (2023).
  17. Photo-on-Demand In Situ Synthesis of N‑Substituted Trichloroacetamides with Tetrachloroethylene and Their Conversions to Ureas, Carbamates, and Polyurethanes
    T. Akamatsu, M. Shele, A. Matsune, Y. Kashiki, F. Liang, T. Okazoe, A. Tsuda
    ACS Omega, 8, 2669–2684 (2023).
  18. Reactivity and Product Selectivity of Fluoroalkyl Carbonates in Substitution Reactions with Primary Alcohols and Amines
    S. Hatsumura, Y. Hashimoto, S. Hosokawa, A. Nagao, K. Eda, H. Harada, K. Ishitsuka, T. Okazoe, A. Tsuda
    J. Org. Chem., 87, 11572–11582 (2022).
  19. Electron in a cube: Synthesis and characterization of perfluorocubane as an electron acceptor
    Sugiyama, M.; Akiyama, M.*; Yonezawa, Y.; Komaguchi, K.; Higashi, M.; Nozaki, K.; Okazoe, T.
    Science, 377, 756–759 (2022).
  20. Photo-on-demand Phosgenation Reactions with Chloroform Triggered by Cl2 upon Irradiation with Visible Light: Syntheses of Chloroformates, Carbonate Esters, and Isocyanates
    Y. Suzuki, F. Liang, T. Okazoe, H. Okamoto, Y. Takeuchi, A. Tsuda
    Chem. Lett., 51, 549–551 (2022).
  21. Synthesis of Crystalline CF3-Rich Perfluoropolyethers from Hexafluoropropylene Oxide and (Trifluoromethyl)trimethylsilane
    Koyama, M.; Akiyama, M.*; Kashiwagi, K.; Nozaki, K.; Okazoe, T.
    Macromol. Rapid Commun., 43, 2200038 (2022).
  22. Photo-on-Demand Phosgenation Reactions with Chloroform for Selective Syntheses of N-Substituted Ureas and Isocyanates
    R. Muranaka, Y. Liu, I. Okada, T. Okazoe, A. Tsuda
    ACS Omega, 7, 5584–5594 (2022).
  23. An N-Fluorinated Imide for Practical Catalytic Imidations
    Oe, Y.; Yoshida, R.; Tanaka, A.; Adachi, A.; Ishibashi, Y.; Okazoe, T.; Aikawa, K.*; Hashimoto, T.*
    J. Am. Chem. Soc., 144, 2107–2113 (2022).
  24. Highly Active Cross Metathesis of Tetrafluoroethylene with a Seven-membered NHC-Ruthenium Catalyst
    Mori, K.; Akiyama, M.*; Inada, K.; Imamura, Y.; Ishibashi, Y.; Takahira, Y.; Nozaki, K.*; Okazoe, T.
    J. Am. Chem. Soc., 143, 20980–20987 (2021).
  25. Photo-on-Demand Base-Catalyzed Phosgenation Reactions with Chloroform: Synthesis of Arylcarbonate and Halocarbonate Esters
    Y. Hashimoto, S. Hosokawa, F. Liang, Y. Suzuki, N. Dai, G. Tana, K. Eda, T. Kakiuchi, T. Okazoe, H. Harada, A. Tsuda
    J. Org. Chem., 86, 9811–9819 (2021).
  26. Bench-Stable Electrophilic Fluorinating Reagents for Highly Selective Mono- and Difluorination of Silyl Enol Ethers
    A. Adachi, K. Aikawa, Y. Ishibashi, K. Nozaki, T. Okazoe
    Chem. Eur. J., 27, 11919–11925 (2021).
  27. Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses
    F. Liang, K. Eda, T. Okazoe, A. Wada, N. Mori, K. Konishi, A. Tsuda
    J. Org. Chem., 86, 6504–6517 (2021).
  28. Synthesis of Fluorinated Dialkyl Carbonates from Carbon Dioxide as a Carbonyl Source
    M. Sugiyama, M. Akiyama, K. Nishiyama, T. Okazoe, K. Nozaki
    ChemSusChem, 13, 1775–1784 (2020).
  29. Cyanide Free One-pot Synthesis of Methacrylic Esters from Acetone
    M. Koyama, T. Kawakami, T. Okazoe, K. Nozaki
    Chem. Eur. J., 25, 10913-10917 (2019).
  30. Application of Liquid-Phase Direct Fluorination: Novel Synthetic Methods for a Polyfluorinated Coating Material and a Monomer of a Perfluorinated Polymer Electrolyte Membrane
    T. Okazoe, D. Shirakawa, K. Murata
    Appl. Sci., 2, 327-341 (2012).
  31. Elemental fluorine. Part 24. [1]: fluorination of ethers by fluorine and Selectfluor
    R. D. Chambers, T. Okazoe, G. Sandford, E. Thomas, J. Trmcic
    J. Fluorine Chem., 131, 933-936 (2010).
  32. Elemental fluorine. Part 23. Direct fluorination of β-ketoesters as an approach to enantio selective fluorination
    R. D. Chambers, T. Nakano, T. Okazoe, G. Sandford
    J. Fluorine Chem., 130, 792-798 (2009).
  33. Elemental fluorine. Part 21. Direct fluorination of benzaldehyde derivatives
    R. D. Chambers, G. Sandford, J. Trmcic, T. Okazoe
    Org. Process Res. Dev., 12, 339-344 (2008).
  34. Synthesis and polymerization of a novel perfluorinated monomer
    E. Murotani, S. Saito, M. Sawaguchi, H. Yamamoto, Y. Nakajima, T. Miyajima, T. Okazoe
    J. Fluorine Chem., 128, 1131-1136 (2007).
  35. Synthesis of perfluorinated ketones by utilizing liquid-phase direct fluorination
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, H. Takagi, K. Kawahara, S. Tatematsu
    Bull. Chem. Soc. Jpn., 80, 1611-1616 (2007).
  36. Synthesis of perfluorinated carboxylic acid membrane monomer by utilizing liquid-phase direct fluorination
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, K. Kawahara, S. Tatematsu
    J. Fluorine Chem., 126, 521-527 (2005).
  37. The modeling of ArF immersion lithography liquid
    J. Irisawa, T. Okazoe, T. Eriguchi, O. Yokokoji
    Reports Res. Asahi Glass Co., Ltd., 55, 53-59 (2005).
  38. Varsatile gas/liquid microreactors for industry
    R. D. Chambers, M. A. Fox, D. Holling, T. Nakano, T. Okazoe, G. Sandford
    Chem. Eng. Tech., 28, 344-352 (2005).
  39. Elemental fluorine. Part 16. Varsatile thin-film gas-liquid multi-channel microreactors for effective scale-out
    R. D. Chambers, M. A. Fox, D. Holling, T. Nakano, T. Okazoe, G. Sandford
    Lab on a Chip, 5, 191-198 (2005).
  40. An entirely new methodology for synthesizing perfluorinated compounds: synthesis of perfluoroalkanesulfonyl fluorides from non-fluorinated compounds
    T. Okazoe, E. Murotani, K. Watanabe, M. Itoh, D. Shirakawa, K. Kawahara, I. Kaneko, S. Tatematsu
    J. Fluorine Chem., 125, 1695-1701 (2004).
  41. Synthesis of a novel trifluoromethanesulfonamidophenyl-substituted quinoline derivative, GA0113, and its pharmacological profiles
    Y. Morizawa, T. Okazoe, S. Wang, J. Sasaki
    Reports Res. Asahi Glass Co., Ltd., 52, 21-26 (2002).
  42. A new route to perfluoro(alkoxyalkanoyl) fluorides from non-fluorinated compounds
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, H. Murofushi, K. Kawahara, S. Tatematsu
    Reports Res. Asahi Glass Co., Ltd., 51, 33-37 (2001).
  43. A novel trifluoromethanesulfonamidophenyl-substituted quinoline derivative, GA0113: synthesis and pharmacological profiles
    Y. Morizawa, T. Okazoe, S-Z. Wang, J. Sasaki, H. Ebisu, M. Nishikawa, H. Shinyama
    J. Fluorine Chem., 109, 83-86 (2001)
  44. A new route to perfluorinated vinyl ether monomers: synthesis of perfluoro(alkoxyalkanoyl) fluorides from non-fluorinated compounds
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, S. Tatematsu
    J. Fluorine Chem., 112, 109-116 (2001).
  45. A new route to perfluoro(propyl vinyl ether) monomer: synthesis of perfluoro(2-propoxypropionyl) fluoride from non-fluorinated compounds
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, H. Murofushi, H. Okamoto, S. Tatematsu
    Adv. Synth. Catal., 343, 215-219 (2001).
  46. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-reseptor antagonist
    H. Ebisu, M. Nishikawa, M. Tanaka, T. Okazoe, Y. Morizawa, H. Shinyama, N. Nakamura
    J. Cardiovasc. Pharmacol., 34, 526-532 (1999).
  47. Alkylidenation of ester carbonyl groups: (Z)-1-ethoxy-1-phenyl-1-hexene
    K. Takai, Y. Kataoka, J. Miyai, T. Okazoe, K. Oshima, K. Utimoto
    Org. Synth., 73, 73-84 (1996).
  48. Regio- and stereoselective preparation of silyl enol ethers by alkylidenation of silyl esters
    K. Takai, Y. Kataoka, T. Okazoe, K. Utimoto
    Tetrahedron Lett., 29, 1065-1068 (1988).
  49. Stereoselective synthesis of (E)-alkenylsilanes from aldehydes with a reagent prepared by chromium(II) reduction of trimethyl(dibromomethyl)silane
    K. Takai, Y. Kataoka, T. Okazoe, K. Utimoto
    Tetrahedron Lett., 28, 1443-1446 (1987).
  50. (E)-Selective olefination of aldehydes by means of gem-dichromium reagents derived by reduction of gem- diiodoalkanes with chromium(II) chloride
    T. Okazoe, K. Takai, K. Utimoto
    J. Am. Chem. Soc., 109, 951-953 (1987).
  51. Alkylidenation of ester carbonyl groups by means of a reagent derived from RCHBr2, Zn, TiCl4, and TMEDA. Stereoselective preparation of (Z)-alkenyl ethers
    T. Okazoe, K. Takai, K. Oshima, K. Utimoto
    J. Org. Chem., 52, 4410-4412 (1987).
  52. Chemoselective methylenation with a methylene dianion synthon
    T. Okazoe, J. Hibino, K. Takai, H. Nozaki
    Tetrahedron Lett., 26, 5581-5584 (1985).
  53. Carbonyl methylenation of easily enolizable ketones
    J. Hibino, T. Okazoe, K. Takai, H. Nozaki
    Tetrahedron Lett., 26, 5579-5580 (1985).
  54. Isomerization of allylic alcohols catalyzed by vanadium or molybdenum complexes
    S. Matsubara, T. Okazoe, K. Takai, H. Nozaki
    Bull. Chem. Soc. Jpn., 58, 844-849 (1985).

Reviews & Accounts

  1. Fluoroarenes
    T. Okazoe and Y. Ishibashi,
    In: Industrial Arene Chemistry (ed. J. Mortier), Wiley-VCH GmbH, Weinheim (2023)
  2. ペルフルオロ構造を利用したペプチドや核酸の細胞内送達技術
    岡添隆、相川光介、木幡愛
    新規モダリティ医薬品のための新しいDDS技術と製剤化、技術情報協会(2023)
  3. Perfluoro-containing Compounds as a Tool for Drug Delivery Systems.
    K. Aikawa and T. Okazoe,
    In: Perfluoroalkyl Substances -Synthesis, Applications, Challenges and Regulations (ed. B. Améduri), RSC (2022).
  4. Perfluorination with F2
    T. Okazoe
    Fluorination. Synthetic Organofluorine Chemistry (Eds. J. Hu, T. Umemoto), Springer, Singapore (2019).
  5. Development of the “PERFECT” direct fluorination method and its industrial applications
    T. Okazoe
    J. Fluorine Chem., 174, 120-131 (2015).
  6. Industrial synthesis of perfluorinated building blocks by liquid-phase direct fluorination
    T. Okazoe
    Pharmaceutical Process Chemistry (Ed. T. Shioiri, K. Izawa, T. Konoike), Wiley-VCH, Weinheim, pp. 145-158 (2011).
  7. Development of a new synthetic route for CHCl3 that does not produce CCl4.
    H. Okamoto, T. Okazoe
    Fine Chemical,39(12), 37-42 (2010).
  8. A new non-phosgene synthetic method of polycarbonates
    J. Nomura, H. Okamoto, T. Okazoe
    Expected Materials for the Future, 10(9), 47-51 (2010)
  9. Development of an entirely new synthetic method for fluorinated compounds “the PERFECT” and its applications
    T. Okazoe
    MATERIAL STAGE, 10(5), 19-21 (2010).
  10. A new synthetic method of fluorinated compounds
    T. Okazoe
    Kagaku To Kogyo (Osaka), 84, 293-298 (2010).
  11. A synthetic method for the production of perfluorinated building blocks: the “perfect” direct fluorination technique
    T. Okazoe
    Chimica Oggi, 28, 29-32 (2010).
  12. A ‘perfect’ perfluorination technique
    T. Okazoe
    Speciality Chemicals Magazine, 29(9), 44-45 (2009).
  13. Overview on the history of organofluorine chemistry from the viewpoint of Material industry
    T. Okazoe
    Proc. Jpn. Acad. Ser. B, 85, 276-289 (2009).
  14. “PERFECT”: An entirely new methodology for synthesizing perfluorinated compounds
    T. Okaoze
    J. Synth. Org. Chem, Jpn,61, 164-169 (2003).

Presentations

  1. Development of the “PERFECT” direct fluorination method, and its industrial applications
    T. Okazoe
    International Conference on Fluorine Chemistry 2014Tokyo (ICFC2014), Yokohama, May 29, 2014.
  2. An entirely new methodology for synthesizing perfluorinated compounds
    T. Okazoe
    The First International Symposium on Process Chemistry (ISPC 08), Kyoto, Jul. 30, 2008.
  3. An entirely new methodology for synthesizing perfluorinated compounds
    T. Okazoe, E. Murotani, K. Watanabe, M. Itoh, D. Shirakawa, K. Kawahara, I. Kaneko, S. Tatematsu
    International Conference on Fluorine Chemistry ’04 Kyoto (ICFC’04), Kyoto, May 10, 2004.
  4. Synthesis of perfluoroketones and perfluorosulfonic acid derivatives by utilizing direct fluorination
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, K. Kawahara, I. Kaneko, S. Tatematsu
    ACS 16th Winter Fluorine Conference, St. Petersburgh, Jan. 16, 2003.
  5. A new route to perfluorinated carboxylic acid membrane monomers: syntheses of perfluorinated diacyl fluorides from non-fluorinated compounds
    T. Okazoe, K. Watanabe, S. Tatematsu, M. Itoh, D. Shirakawa, M. Iwaya, S. Okamoto
    ACS, Boston, Aug. 18, 2002.
  6. Synthesis of versatile perfluorinated monomers from non-fluorinated compounds
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, H. Murofushi, S. Tatematsu
    ACS 15th Winter Fluorine Conference, St. Petersburgh, Jan. 15, 2001.

Patents

  1. Artificial virus capsid
    Y. Ota, T. Okazoe, K. Aikawa, S. Sando, J. Morimoto, K. Matsuura, H. Furukawa
    WO2024228371 (2024/11/7)
  2. Method for producing carbonate compound
    A. Tsuda, T. Okazoe, Y. Takeuchi
    WO2024214280 (2024/10/17)
  3. Method for producing aryl compound containing tritylsulfanyl group
    T. Okazoe, K. Nozaki, T. Gatzenmeier, Y. Liu
    WO2024185814 (2024/9/12)
  4. Isosorbide polyurethane and method for producing same
    T. Okazoe, C. Suzuki, A. Tsuda
    WO2024185765 (2024/9/12)
  5. Method for producing reticulated polyurethane
    T. Okazoe, C. Suzuki, A. Tsuda
    WO2024166798 (2024/8/15)
  6. Anticancer agent
    T. Okazoe, K. Kashiwagi, Y. Ota, T. Osawa, K. Aikawa, S. Aki, M. Sugaya
    WO2024135746 (2024/6/27)
  7. Electret material and skin-patch type electret energy harvesting device using same
    Y. Suzuki, K. Suzuki, K. Kashiwagi, N. Sugiyama, Y. Hattori, T. Okazoe
    WO2024096061 (2024/5/10)
  8. Cell-membrane-permeable peptide for conjugation
    Y. Ota, T. Okazoe, K. Aikawa, A. Kohata, S. Sando, J. Morimoto, K. Kadota
    WO2024090491 (2024/5/2)
  9. Fluonine-containing compound production method
    K. Aikawa, K. Nozaki, T. Gatzenmeier, R. Hagiwara, K. Matsumoto, Y. Ishibashi, K. Kashiwagi, T. Okazoe
    WO2024090485 (2024/5/2)
  10. Nucleic acid for transfection
    T. Okazoe, A. Okamoto, K. Morihiro, A. Kohata
    WO2024053720 (2024/3/14)
  11. Fluoroalkene copolymer
    K. Kashiwagi, T. Okazoe, N. Sugiyama, M. Akiyama, A. Kohata, J. Masuda, M. Okuda
    WO2024038854 (2024/2/22)
  12. Nucleic acid for transfection
    T. Okazoe, A. Okamoto, K. Morihiro
    WO2024038781 (2024/2/22)
  13. Production method for fluorine^containing compound
    T. Okazoe, K. Aikawa, K. Nozaki, A. Adachi
    WO2023171697 (2023/9/14)
  14. Polyurethane production method
    A. Tsuda, T. Okazoe
    WO2023080052 (2023/5/11)
  15. Production method for fluorine^containing polyurethane
    A. Tsuda, T. Okazoe, H. Wada, H. Tanaka, Y. Sunayama, T. Kakiuchi
    WO2023080049 (2023/5/11)
  16. Method for producing tetrafluorosulfanyl group-containing aryl compound
    T. Okazoe, K. Aikawa, K. Nozaki, E. Yasuo
    WO2023048244 (2023/3/30)
  17. Amino fluorinating agent and method for producing amino fluorinating agent
    T. Okazoe, K. Aikawa, K. Nozaki, Y. Ito
    WO2023048237 (2023/3/30)
  18. Peptide
    K. Kashiwagi, T. Okazoe, K. Aikawa, S. Sando, J. Morimoto, K. Kadota, A. Kohata
    WO2023048236 (2023/3/30)
  19. Method for producing polycarbonate
    T. Okazoe, M. Suzuki
    WO2022244856 (2022/11/24)
  20. Acyclic threoninol nucleic acid
    T. Okazoe, K. Aikawa, H. Watanabe, A. Okamoto, K. Morihiro, T. Kageyama
    WO2022186530 (2022/9/9)
  21. Production method of arylthiol ester compound
    T. Okazoe, T. Gatzenmeier, K. Nozaki
    WO2022186305 (2022/9/9)
  22. Method for producing pentafluorosulfanyl group-containing aryl compound
    T. Okazoe, T. Gatzenmeier, K. Nozaki
    WO2022186304 (2022/9/9)
  23. Method for producing halogenated carbonyl
    A. Tsuda, T. Okazoe
    WO2022172745 (2022/8/18)
  24. Method for producing carbonyl halide
    A. Tsuda, T. Okazoe, H. Harada
    WO2022172744 (2022/8/18)
  25. Peptide
    K. Kashiwagi, T. Okazoe, K. Aikawa, J. Morimoto, S. Sando, T. Mikami
    WO2022149584 (2022/7/14)
  26. Method for producing carbonate compound
    A. Tsuda, T. Okazoe
    WO2022065133 (2022/3/31)
  27. Fluorinating agent and method for producing fluorine-containing compound
    T. Okazoe, Y. Ishibashi, K. Nozaki, K. Aikawa, A. Adachi
    WO2022025117 (2022/2/3)
  28. Method for manufacturing polyurethane
    A. Tsuda, T. Okazoe, H. Wada, H. Tanaka, Y. Sunayama, T. Kakiuchi
    WO2021230151 (2021/11/18)
  29. Peptide and cell membrane permeation agent
    J. Morimoto, S. Sando, T. Ono, K. Aikawa, T. Okazoe
    WO2021177336 (2021/9/10)
  30. Method for producing fluorine-containing olefin
    K. Nozaki, M. Akiyama, K. Mori, T. Okazoe, Y. Ishibashi, K. Inada
    WO2021177000 (2021/9/10)
  31. Perfluoroalkyl group-containing nucleic acid and production method theirfor
    T. Okazoe, Y. Ishibashi, A. Okamoto, K. Morihiro, K. Aikawa, H. Watanabe
    WO2021060506 (2021/4/1)
  32. Aminating agent and method for producing aminated product
    T. Okazoe, Y. Ishibashi, K. Nozaki, K. Aikawa, T. Hashimoto
    WO2021060277(2021/4/1)
  33. Fluorinating agent and method for producing fluorine-containing compounds
    T. Okazoe, Y. Ishibashi, K. Nozaki, K. Aikawa, A. Adachi
    WO2021060276 (2021/4/1)
  34. Method for producing carbonyl halide
    A. Tsuda, T. Okazoe, H. Okamoto
    WO2021045105 (2021/3/11)
  35. Production method for nitrogen-containing fluorine-containing compound
    T. Okazoe, Y. Ishibashi
    WO2021033649 (2021/2/25)
  36. Peptide and method for manufacturing same
    T. Okazoe, Y. Ishibashi, S. Sando, J. Morimoto, K. Aikawa, T. Mikami, T. Ono
    WO2021002408 (2021/1/7)
  37. Fluoroalkyl group-containing compound and production method thereof
    T. Okazoe, Y. Ishibashi, K. Aikawa, T. Mikami, K. Nozaki
    WO2021002407 (2021/1/7)
  38. Method for producing N-substituted trihaloacetamide
    A. Tshda, T. Okazoe, H. Wada, Y. Sugiyama, T. Kakiuchi
    WO2020196553 (2020/10/1)
  39. Production method for isocyanate compound
    A. Tsuda, T. Okazoe
    WO2020100971 (2020/5/22)
  40. Method for producing halogenoformic acid halogenated alkyl ester
    A. Tsuda, T. Okazoe
    WO2020100970 (2020/5/22)
  41. 含フッ素炭酸エステルの製造方法
    岡添 隆；秋山 みどり；杦山 真史；西山 航平；野崎 京子
    特開2020-55792 (2020/4/9)
  42. Method for preparing Vilsmeier reagent
    A. Tsuda, T. Okazoe, A. Wada, N. Mori, K. Konishi
    WO2020050368 (2020/3/12)
  43. Production method for alfa,beta-unsaturated acid ester or alfa-haloester
    T. Okazoe, M. Koyama, T. Kawakami, K. Nozaki
    WO2018159846 (2018/9/7)
  44. Polycarbonate manufacturing method and polycarbonate
    N. Shirota, T. Okazoe, K. Kashiwagi
    WO 2014171367 (2015/10/23)
  45. Method of producing aromatic urea compound
    Y. Morizawa, T. Okazoe
    JP2015182965 (2015/10/22)
  46. Manufacture of carbonate compounds and methacrylic acid or its esters
    T. Okazoe, M. Miyazaki, K. Oharu, T. Fujita, S. Wada, K. Murata, N. Shirota
    WO 15/122476 (2015/8/20)
  47. Discoloration-free high-molecular-weight polycarbonate and its manufacture at relatively low temperature by using fluorine-containing carbonate monomer
    N. Shirota, T. Okazoe, K. Kashiwagi
    WO 14/171367 (2014/10/23)
  48. Method for producing carbonate compound
    H. Okamoto, A. Fujimori, T. Okazoe
    WO 14/88029 (2014/6/12)
  49. Method for producing unsaturated acid and/or unsaturated acid ester
    T. Fujita, S. Wada, T. Okazoe, K. Murata
    WO 14/38489 (2014/3/13)
  50. Manufacture of polyester-carbonates from fluorine-containing dicarboxylates and fluorine-containing carbonates
    S. Wada, T. Okazoe, H. Okamoto, A. Fujimori, K. Kashiwagi
    WO 14/27586 (2014/2/20)
  51. Separation method, purification method and production method of diol and dibutyl carbonate
    T. Fujita, T. Okazoe
    WO 13/150989 (2013/10/10)
  52. Method for producing polyester, and fluorine-containing dicarboxylic acid ester compound
    J. Nomura, H. Okamoto, A. Fujimori, T. Okazoe
    WO 12/118084 (2012/9/7)
  53. Carbamate compound, and method for the preparation of isocyanate therefrom
    T. Okazoe, Y. Nakasaki, H. Okamoto
    WO 11/125429 (2011/10/13)
  54. Manufacture of polycarbonate with good transparency
    J. Nomura, H. Okamoto, T. Okazoe
    WO 11/62121 (2011/5/26)
  55. Manufacture of polycarbonate with good transparency
    J. Nomura, H. Okamoto, T. Okazoe
    WO 11/62104 (2010/5/26)
  56. Processes for production of isocyanate, urethane and blocked isocyanate compound
    Y. Sasao, H. Okamoto, T. Okazoe
    WO 11/49023 (2011/4/28)
  57. Method for production of polycarbonate for engineering plastic
    J. Nomura, T. Okazoe, H. Okamoto, N. Kasahara, K. Yamamoto
    WO 11/24732 (2011/3/3)
  58. Chlorotrifluoroethylene copolymers and membranes
    A. Safir, S. Li, S. Okada, N. Kasahara, K. Ueno, Y. Morizawa, T. Okazoe
    WO 11/13849 (2011/2/3).
  59. Manufacture of 2-chloro-1, 1, 1, 2-tetrafluoropropane and 2, 3, 3, 3- tetrafluoropropene
    S. Kawaguchi, T. Okazoe, H. Okamoto
    WO 10/71136 (2010/6/24).
  60. Manufacture of diphenyl carbonate from fluorine-containing carbonates
    T. Okazoe, H. Okamoto, K. Tajima, Y. Nagasaki
    WO 10/1870 (2010/1/7).
  61. Method for producing polycarbonate
    T. Okazoe, H. Okamoto, K. Tajima, K. Yamamoto
    WO 09/123083 (2009/10/8).
  62. Method for producing fluoroalkyl carbonate compound
    H. Okamoto, K. Tajima, T. Okazoe
    WO 09/72502 (2009/6/11).
  63. Method for producing alkyl carbonate, cyclic carbonates, and polycarbonates
    H. Okamoto, K. Tajima, T. Okazoe
    WO 09/72501 (2009/6/11).
  64. Optical polymer compositions containing fluorine-containing polycyclic compounds as refractive index controllers, and their use
    M. Sato, K. Kurashima, H. Yamamoto, T. Okazoe
    JP 2008-3351 (2008/1/10).
  65. 1, 3, 5-tris[3, 4, 5-trifluoro-2-(trifluoromethyl)phenyl]benzenes as refractive index controllers for plastic optical fibers and their manufacture
    M. Sato, K. Kurashima, H. Yamamoto, T. Okazoe
    JP 2008-1652 (2008/1/10).
  66. Novel fluorine surface active agents and compounds therefrom
    T. Okazoe, Y. Akiyama
    WO 07/81008 (2007/7/19).
  67. Manufacture of polyurethanes with fluoroadamantane units
    S-Z. Wang, K. Kashiwagi, T. Okazoe
    JP 2007-131669 (2007/5/31).
  68. Compounds having perfluoro(1, 3-dioxolan)-derived units and their polymers having amorphous structure
    E. Murotani, Y. Akiyama, T. Okazoe, M. Saito
    JP 2006-290779 (2006/10/26).
  69. Compounds having perfluoro(2, 2-divinyl-1, 3-dioxolan) moieties and fluoropolymers therefrom
    E. Murotani, T. Okazoe, Y. Akiyama
    JP 2006-282619 (2006/10/19).
  70. Preparation of fluorospiroketal structure-containing polymers useful for optical materials
    K. Kashiwagi, D. Shirakawa, T. Okazoe, K. Tamao, K. Nakano
    WO 06/95790 (2006/9/14).
  71. Perfluoro(2-vinyl-1, 3-dioxolane) compounds and amorphous fluoropolymers from them with excellent heat resistance
    E. Murotani, T. Okazoe, M. Saito
    JP 2006-241302 (2006/9/14).
  72. Immersion exposure method and medium for it
    J. Irisawa, T. Okazoe, T. Eriguchi
    JP 2006-142409 (2006/6/1).
  73. Manufacture of adamantine reaction products
    S-Z. Wang, K. Kashiwagi, T. Okazoe
    JP 2006-137798 (2006/6/1).
  74. Polymerizable fluorinated polyethers and their solutions with improved resistance to Lewis acids and heat
    S-Z. Wang, D. Shirakawa, T. Eriguchi, T. Okazoe, K. Suzuki
    JP 2006-76893 (2006/3/23).
  75. Preparation of perfluorinated cyclic ethers
    Y. Hoshino, T. Okazoe
    JP 2006-63013 (2006/3/9).
  76. Fluorine-containing ethers and their use
    D. Shirakawa, K. Oharu, T. Okazoe, S-Z. Wang
    JP 2006-45159 (2006/2/16).
  77. Tetrafluoroethylene copolymers having good impermeability against gases and chemicals
    A.Funaki, K. Oharu, T. Okazoe
    JP 2006-16540 (2006/1/19).
  78. Synthesis of fluorinated adamantine and its derivatives
    T. Okazoe, K. Watanabe, M. Itoh, E. Murotani, K.Oharu, S-Z. Wang, T. Hoshino, K. Kashiwagi
    US 2005-288528 (2005/12/29).
  79. Compound having perfluoro(4-methylene-1, 3-dioxolane) structure and novel polymer
    E. Murotani, M. Sawaguchi, H. Yamamoto, T. Okazoe, S. Saitou
    WO 05/121118 (2005/12/22).
  80. Water-repellent composition, water-repellent thin film, and thin film with water-repellent/hydrophilic pattern
    Y. Furukawa, T. Okazoe
    WO 05/119367 (2005/12/15).
  81. Fluoropolyether compounds useful as lubricants, surfactants, and surface modifiers
    D. Shirakawa, K. Oharu, T. Okazoe
    WO 05/68534 (2005/7/28).
  82. Preparation of fluorine-containing silane compounds, water repellent composition, and thin film
    T. Hoshino, Y. Furukawa, T. Okazoe
    WO 05/54256 (2005/6/16).
  83. Novel fluorine compounds for fluoropolymers with good mechanical properties and transparency and high refractive index and glass transition temperature
    T. Eriguchi, T. Okazoe, E. Murotani, M. Itoh, K. Watanabe
    WO 05/42511 (2005/5/12).
  84. Fluorine-containing dioxolane compounds and their polymers
    N. Sugiyama, M. Itoh, E. Murotani, T. Okazoe
    WO 05/37818 (2005/4/28).
  85. Process for production of fluorinated sulfonyl fluorides useful for ion exchange resins and chemical-resistant substances
    K. Murata, T. Okazoe, E. Murotani
    WO 05/3082 (2005/1/13).
  86. Process for preparation of perfluorinated sulfonyl fluorides
    K. Murata, T. Okazoe, E. Murotani
    WO 05/3062 (2005/1/13).
  87. Preparation of perfluorovinyl ether and their intermediates
    E. Murotani, T. Okazoe
    JP 2004-323413 (2004/11/18).
  88. Method for producing fluorine-containing sulfonyl fluoride compound
    K. Murata, T. Okazoe, E. Murotani
    WO 04/94365 (2004/11/4).
  89. Preparation of high-purity 2-monofluoro-3-oxoalkanoic acids by fluorination using them as solvents
    R. D. Chambers, K. Hayashi, T. Okazoe
    JP 2004-292413 (2004/10/21).
  90. Process for preparation of perfluorodiacyl fluorides
    S-Z. Wang, T. Okazoe, E. Murotani, K. Watanabe, D. Shirakawa, K. Oharu
    WO 04/80940 (2004/9/23).
  91. Process for preparation of fluorinated adamantine derivatives
    T. Okazoe, K. Watanabe, M. Itoh, E. Murotani
    WO 04/52832 (2004/6/24).
  92. Perfluoropolyether derivatives
    D. Shirakawa, T. Okazoe, K. Oharu, S-Z. Wang, K. Murata, K. Kawahara
    WO 04/35656 (2004/4/29).
  93. Preparation of chlorodifluoroacetyl fluoride and its derivatives
    M. Itoh, T. Okazoe, K. Watanabe, E. Murotani, S. Tatematsu
    JP 2003-313152 (2003/11/6).
  94. Preparation of fluorine-containing dicarbonyl compounds
    E. Muratani, K. Watanabe, H. Okamoto, H. Takagi, S. Tatematsu, T. Okazoe
    JP 2003-238461 (2003/8/27).
  95. Fluorosulfonyl compounds and process for production of compounds derived therefrom
    T. Okazoe, A. Watakabe, M. Itoh, K. Watanabe, T. Eriguchi, K. Kashiwagi, S. Wang
    WO 03/37885 (2003/5/8).
  96. Fluorine-containing diene compounds, fluoropolymers and processes for production of both
    K. Kashiwagi, G. Ogawa, T. Okazoe, K. Watanabe, E. Murotani, K. Oharu
    WO 03/37838 (2003/5/8).
  97. Process for preparation of fluorine-containing carbonyl compounds
    K. Oharu, T. Okazoe, K. Watanabe, D. Shirakawa
    WO 03/2501 (2003/1/9).
  98. Process for producing fluorinated polyoxyalkylene compounds
    D. Shirakawa, T. Okazoe, N. Sugiyama, G. Enna, S. Tatematsu
    WO 02/88218 (2002/11/7).
  99. Process for producing acrylic fluoropolymers and their derivatives use as coatings
    D. Shirakawa, T. Okazoe, T. Maekawa, K. Oharu, M. Unoki
    WO 02/79274 (2002/10/10).
  100. Method for producing fluorine-containing polymers
    D. Shirakawa, T. Okazoe, K. Watanabe, S. Tatematsu
    WO 02/74815 (2002/9/26).
  101. Preparation of vic-dichloro acid fluorides as intermediates for monomers for fluoropolymers
    T. Okazoe, K. Oharu, K. Watanebe, S. Tatematsu
    JP 2002-255901 (2002/9/11).
  102. Processes for Producing Fluorinated Cyclic Ethers and Use Thereof
    H. Okamoto, T. Okazoe, K. Watanabe, M. Itoh
    WO 02/66452 (2002/8/29).
  103. 1-Hydroxyperfluorocycoalkanol-tape cleaning agents for semiconductor substrates
    H. Okamoto, T. Okazoe
    特開2002-220598 (2002/8/9).
  104. Processes for producing fluorinated ester, fluorinated acyl fluoride, and fluorinated vinyl ether
    T. Okazoe, K. Watanabe, S. Tatematsu, H. Murofushi, M. Sato, M. Itoh, K. Yanase, Y. Suzuki
    WO 02/55471 (2002/7/18).
  105. Process for producing product of decomposition of fluorinated ester compound
    K. Watanabe, Y. Suzuki, K. Yanase, T. Okazoe
    WO 02/48085 (2002/6/20).
  106. Process for producing fluorosulfonyl fluoride compound
    M. Itoh, K. Watanabe, T. Okazoe, I. Kaneko, D. Shirakawa
    WO 02/44138 (2002/6/6).
  107. Process for preparing fluorinated esters by gas chromatography
    K. Kawahara, T. Isemura, T. Okazoe
    WO 02/40437 (2002/5/23).
  108. Process for producing fluoroamine compound
    M. Itoh, K. Watanabe, D. Shirakawa, T. Okazoe, S. Tatematsu
    WO 02/26693 (2002/4/4).
  109. Process for producing fluorinated polyvalent carbonyl compound
    T. Okazoe, K. Watanabe, D. Shirakawa, M. Itoh, S. Tatematsu
    WO 02/26689 (2002/4/4).
  110. Process for producing fluorinated ester compound
    T. Okazoe, K. Watanabe, S. Tatematsu, K. Yanase, Y. Suzuki, D. Shirakawa
    WO 02/26688 (2002/4/4).
  111. Processes for the preparation of perfluoro compounds and derivatives thereof
    K. Watanabe, T. Okazoe, S. Tatematsu, D. Shirakawa
    WO 02/26687 (2002/4/4).
  112. Process for producing acyl fluoride and carboxylic acid salt
    K. Watanabe, T. Okazoe, M. Itoh, S. Tatematsu, H. Kamiya, E. Murotani
    WO 02/26686 (2002/4/4).
  113. Process for producing fluorinated vinyl ethers
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, S. Tatematsu
    WO 02/26682 (2002/4/4).
  114. Process for producing fluorinated alcohol
    H. Okamoto, T. Okazoe, K. Watanabe, H. Takagi
    WO 02/26679 (2002/4/4).
  115. Process for the preparation of fluorinated unsaturated compounds and process for the production of fluoropolymers
    H. Okamoto, H. Takagi, T. Okazoe
    WO 02/20445 (2002/3/14).
  116. Process for producing fluorinated ketones from alkanols by fluorination with fluorine gas
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, S. Tatematsu, H. Takagi
    WO 02/18314 (2002/3/7).
  117. Process for producing fluorinated secondary alcohol and fluorinated ester through transesterificaion
    M. Itoh, T. Okazoe, H. Okamoto, K. Watanabe, S. Tatematsu, D. Shirakawa
    WO 02/10108 (2002/2/7).
  118. Process for the preparation of perfluoroacyl fluorides
    T. Okazoe, H. Murofushi, K. Watanabe, S. Tatematsu
    WO 02/10107 (2002/2/7).
  119. Process for the preparation of fluorinated acyl fluorides and fluorinated vinyl ethers
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, S. Tatematsu
    WO 02/10106 (2002/2/7).
  120. Preparation of imidazolylquinolines and angiotensin II antagonists
    Y. Takebe, T. Okazoe, Y. Morizawa, K. Hirai, Y. Kubo, K. Hayashi, H. Ebisu, H. Mayama
    JP 2002-300855 (2002/1/29).
  121. Method for producing fluorinated compounds
    T. Okazoe, K. Watanabe, S. Tatematsu, M. Itoh, D. Shirakawa, M. Iwaya, H. Okamoto
    WO 02/4397 (2002/1/17).
  122. Process for preparing unsaturated compounds by pyrolysis
    T. Okazoe, K. Watanabe, S. Tatematsu, M. Sato, H. Murofushi, K. Yanase, Y. Suzuki
    WO 01/94285 (2001/12/13).
  123. Heat resistant amorphous fluoropolymer-based optical resin compositions and their applications
    H. Murofushi, M. Itoh, Y. Takebe, T. Okazoe, J. Irisawa, S. Tatematsu
    JP 2001-302935 (2001/10/31).
  124. Process for producing a fluoride compound
    T. Okazoe, K. Watanabe, S. Tatematsu, Y. Takebe
    WO 01/46093 (2001/6/28).
  125. Process for producing a vic-dichloro acid fluoride
    T. Okazoe, K. Watanabe, M. Itoh, D. Shirakawa, S. Tatematsu
    WO 01/16085 (2001/3/8).
  126. Process for producing fluorine compound through liquid-phase fluorination
    T. Okazoe, K. Watanabe, S. Tatematsu, H. Murofushi
    WO 00/56694 (2000/9/28).
  127. Preparation of fluoro-containing alcohols
    K. Kashiwagi, T. Okazoe, A. Watakabe
    JP 2000-154158 (2000/6/6).
  128. Process for the preparation of 2, 6-dichloronicotinonitriles
    T. Okazoe, S-Z. Wang
    WO 00/6547 (2000/2/10).
  129. Method for producing n-perfluoropentane by the fluorine fluorination of 2-perfluoropentenes in a solvent
    K. Watanabe, T. Okazoe, S. Tatematsu
    EP 967191 (1999/12/29).
  130. Preparation of quinoline derivatives as angiotensin II antagonists
    S-Z. Wang, T. Okazoe, Y. Morizwa
    JPH 11-255750 (1999/9/21).
  131. Graded-refractive-index optical plastic material
    N. Sugiyama, H. Murofushi, T. Okazoe, M. Tamura, S. Tatematsu, J. Irisawa
    EP 907088 (1999/4/7).
  132. Preparation of 6-substituted 5-fluoropyrimidines as intermediates for fungicides
    T. Asai. T. Okazoe
    JPH 11-49758 (1999/2/23).
  133. Preparation of 9, 10-dihaloanthracenes
    Y. Takebe, H. Murofushi, T. Okazoe, K. Kashiwagi, M. Tamura
    JPH 11-12204 (1999/1/19).
  134. Preparation of 9, 9, 10, 10-tetrachloro-9, 10-dihydroanthracenes
    Y. Takebe, H. Murafushi, T. Okazoe, K. Kashiwagi, M. Tamura
    JPH 11-12203 (1999/1/19).
  135. Preparation of fluorovinyl ethers
    M. Tamura, K. Sakata, T. Okazoe
    JPH 10-212260 (1998/8/11).
  136. Process for producing 2-(carboxyphenyl)-4-quinolinecarboxilyc acid compounds
    Y. Inoue, H. Ebisu, N. Ishida, N. Nakamura, J. Sasaki, T. Okazoe, Y. Morizawa, A. Yasuda, S-Z. Wang, T. Ito
    US 5780634 (1998/7/14).
  137. Crystal of N-[(quinolin-2-yl)phenyl]sulfonamides and process for producing the same
    T. Okazoe, Y. Morizawa
    EP 812841 (1997/12/17).
  138. Method of producing amorphous paroxetine hydrochloride
    S-Z. Wang, T. Okazoe, Y. Matsumura
    EP 810224 (1997/12/3).
  139. Preparation of trans-3-hydroxymethyl-4-phenylpiperidines by reduction of trans-4-phenyl-6-oxo-3-piperidinecarboxylates
    S-Z. Wang, T. Okazoe, Y. Matsumura, N. Mori, J. Nishino, K. Ookura
    EP 802185 (1997/10/22).
  140. Preparation of 2-arylquinolines
    T. Okazoe, Y. Morizawa
    EP 786460 (1997/7/30).
  141. Preparation of 6-aminomethylquinolinylbenzoic acid compounds as antihypertensive agents
    S-Z. Wang, T. Okazoe, Y. Morizawa
    JPH 09-59277 (1997/3/4).
  142. Preparation for producing (quinolin-2-yl)benzoic acids
    S-Z. Wang, T. Ito, T. Okazoe, Y. Morizawa
    EP 709377 (1996/5/1).
  143. Preparation of quinoline derivatives useful as angiotensin II antagonists
    T. Ito, T. Okazoe, Y. Morizawa, Y. Inoue, H. Ebisu, N. Nakamura
    JPH 08-73458 (1996/3/19).
  144. Preparation of quinoline derivatives as angiotensin II antagonists
    S-Z. Wang, T. Okazoe, Y. Morizawa, Y. Inoue, N. Nakamura
    JPH 07-238071 (1995/9/12).
  145. Preparation of indazole derivatives as angiotensin II antagonists
    T. Okazoe, S-Z. Wang, Y. Morizawa, Y. Inoue, H. Ebisu, N. Nakamura
    JPH 07-196655 (1995/8/1).
  146. Method for producing imidazopyridine derivatives by cyclocondensation of 2,3-diaminopyridine with orthoesters
    Y. Morizawa, T. Okazoe, A. Yasuda
    JPH 07-138259 (1995/5/30).
  147. Preparation of alcohols
    S-Z. Wang, T. Okazoe, Y. Morizawa
    JPH 07-109235 (1995/4/25).
  148. Preparation of N-(heterocyclylmethyl)aminopyridine derivative with angiotensin II antagonism and antihypertensive activity
    Y. Morizawa, T. Okazoe, A. Yasuda
    JPH 07-10870 (1995/1/13).
  149. Preparation of imidazopyridine derivatives as angiotensin II antagonists
    T. Okada, T. Okazoe, Y. Morizawa, N. Nakamura, Y. Inoue, H. Ebisu
    JPH 06-184149 (1994/7/5).
  150. Preparation of imidazopyridine derivatives as angiotensin II antagonists
    Y. Morizawa, T. Okada, T. Okazoe, N. Nakamura, Y. Inoue, H. Ebisu
    JPH 06-184148 (1994/7/5).
  151. Preparation of imidazopyridinylphenylisoxazole derivatives as angiotensin II antagonists
    T. Okazoe, Y. Morizawa, A. Yasuda, N. Nakamura, Y. Inoue, N. Ishida
    JPH 06-184147 (1994/7/5).
  152. Preparation of imidazopyridinylalkylbenzazole derivatives as angiotensin II antagonists
    T. Okazoe, Y. Morizawa, A. Yasuda, N. Nakamura, Y. Inoue, H. Ebisu
    JPH 06-73051 (1994/3/15).
  153. Preparation of benzoxazolylbenzoic acids and analogs as angiotensin II antagonists
    T. Okazoe, J. Sasaki, Y. Morizawa, N. Nakamura, Y. Inoue, H. Ebisu
    JPH 06-73050 (1994/3/15).
  154. Preparation of imidazopyridinylmethyldihydrooxoquinolinylbenzoic acids as angiotensin II antagonists
    J. Sasaki, T. Okazoe, Y. Morizawa, N. Nakamura, Y. Inoue, H. Ebisu
    JPH 06-73047 (1994/3/15).
  155. Quinoline compounds as angiotensin II antagonists
    Y. Inoue, H. Ebisu, N. Ishida, N. Nakamura, J. Sasaki, T. Okazoe, Y. Morizawa, A. Yasuda
    EP 569013 (1993/11/10).
  156. Preparation of 2H-indazole derivatives as antihypertensives
    Y. Inoue, H. Ebisu, N. Nakamura, Y. Morizawa, T. Okazoe
    WO 93/19060 (1993/9/30).
  157. Preparation of benzoylacetic acid esters as antibacterial intermediates
    T. Okazoe, T. Tohma, A. Yasuda
    JPH 04-221345 (1992/8/11).
  158. Preparation of benzoyl fluorides from (haloacetyl)benzenes
    S. Kumai, O. Yokokoji, T. Okazoe
    JPH 02-49737 (1990/2/20).
  159. Preparation of ring-fluorinated benzoyl fluorides
    S. Kumai, T. Okazoe, O. Yokokoji
    JPH 02-49736 (1990/2/20).
  160. Fluoro-containing nucleosides as antitumor and antiviral agants
    Y. Morizawa, T. Okazoe, A Suga, T. Asai, A. Yasuda, K. Uchida
    JPH 01-100190 (1989/4/18).