Project 3. Design and Molecular Evolution of Synthetic Oligomers for Manipulating Biological Functions
Ongoing project 1: Exploration of biostable synthetic oligomers that are mainly composed of D-amino acid residues
Peptides containing D-amino acids, which are enantiomers of proteinogenic L-amino acids, are not recognized by proteases and are highly stable in vivo. Besides, peptides containing D-amino acids have been suggested to be of low immunogenicity. Therefore, peptides containing D-amino acids are synthetic oligomers of great potential for new therapeutics. We are conducting screening efforts of a large library of peptides containing D-amino acids to discover bioactive compounds. Thus far, we have successfully discovered a peptide that inhibits protein-protein interaction of MDM2 and p53. This research would allow rapid discovery of highly stable bioactive peptides for new therapeutics.