Project 3. Rational design and high-throughput screening of synthetic molecules for drug discovery.
Our goal is development of bioactive compounds that can be utilized as drug leads and molecular tools for biological studies. Our strategy toward this goal is a combination of rational designs of chemical structure and high-throughput screening of synthetic compound libraries. We envision that this research will reveal fundamental structural elements for producing bioactive compounds of strong and selective biomolecular recognition and high membrane permeability.