Project 1. Exploration of a new research field, "In vivo Chemistry"
The main objective of this project is to develop chemistry-based molecular technologies for analyzing dynamic functions of biomolecules in vivo. Such molecular technologies are expected to facilitate the innovation for early diagnosis of disease and understanding of unknown mechanism of life. To this end, we conduct research toward highly sensitive and selective molecular sensing technologies that allow us to analyze molecular activities in vivo.
1) K. Yamaguchi et al., J. Am. Chem. Soc. 2011, 133, 14208-14211.
2) T. Nishihara et al., Chem. Sci. 2012, 3, 800-806.
3) R. Ueki et al., J. Am. Chem. Soc. 2012, 134, 12398-12401.
4) T. Doura et al., Angew. Chem. Int. Ed. 2012, 51, 10114-10117.
5) H. Nonaka et al., Nat. Commun. 2013, 4, 2411, doi: 10.1038/ncomms3411.
6) R. Hata et al., Angew. Chem. Int. Ed. in press DOI: 10.1002/anie.201509457.