2024

原著論文

• Nakagawa R, Gu W, Mizobuchi H, Kodera S, Takano T, Wang Y, Fujioka I, Uchida K, Nakajima-Adachi H, Hachimura S.

  Lactococcus lactis subsp. cremoris YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells.

  Front Immunol. 2024 Jul 8;15:1395380. PubMed

2023

原著論文

• Hachimura S.

  [ORAL IMMUNOTHERAPY FROM THE VIEW OF ORAL TOLERANCE]

  Arerugi. 2023;72(9):1099-1103. Japanese. PubMed

• Wang Y, Takano T, Zhou Y, Wang R, Toshimitsu T, Sashihara T, Tanokura M, Miyakawa T, Nakajima-Adachi H, Hachimura S.

  Orally administered Lactiplantibacillus plantarum OLL2712 decreased intestinal permeability, especially in the ileum: Ingested lactic acid bacteria alleviated obesity-induced inflammation by collaborating with gut microbiota.

  Front Immunol. 2023 Feb 23;14:1123052. PubMed

2022

原著論文

• Tsuda M, Okada H, Kojima N, Ishihama F, Muraki Y, Oguma T, Hattori N, Mizoguchi T, Mori K, Hachimura S, Takahashi Y, Takahashi K, Kaminogawa S, Hosono A.

  Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota.

  J Immunol Res. 2022 May 4;2022:3974141. PubMed

• Zhou Y, Takano T, Li X, Wang Y, Wang R, Zhu Z, Tanokura M, Miyakawa T, Hachimura S.

  β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway.

  Commun Biol. 2022 May 31;5(1):519. PubMed

• Nakajima-Adachi H, Tamai M, Nakanishi H, Hachimura S.

  Extracts ofGluconacetobacter hansenii GK-1 induce Foxp3⁺T cells in food-allergic mice by an IL-4-dependent or IL-4-independent mechanism.

  Biosci Microbiota Food Health. 2022;41(3):137-144. PubMed

• Uchida K, Iida K, Fujioka I, Hachimura S, Kaminuma O.

  Suppressive Effect of Lactococcus lactis subsp. cremoris YRC3780 on a Murine Model of Japanese Cedar Pollinosis.

  Pathogens. 2022 Nov 14;11(11):1347. PubMed

• Hachimura S.

  Immunomodulation by Food: Novel Collaborations between Food Components and Microbiota.

  J Nutr Sci Vitaminol (Tokyo). 2022;68(Supplement):S126-S127. PubMed

2021

原著論文

• Iida M, Desamero MJ, Yasuda K, Nakashima A, Suzuki K, Chambers JK, Uchida K, Ogawa R, Hachimura S, Nakayama J, Kyuwa S, Miura K, Kakuta S, Hirayama K.

  Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice.

  Sci Rep. 2021 Jul 1;11(1):13640. PubMed

• Yoshida K, Shirane S, Morikawa E, Marsushita S, Toda M, Nakajima-Adachi H., Tanokura M, Akasawa A, Narita M.

  Macadamia nut allergy in children: clinical features and cross-reactivity with walnut

  Pediatr. Allergy Immunol., 32(5):1111-1114. PubMed

• Toshimitsu T., Gotou A., Sashihara T., Furuichi K., Hachimura S., Shioya N., Suzuki S., Asami Y.

  Ingesting Yogurt Containing Lactobacillus plantarum OLL2712 Reduces Abdominal Fat Accumulation and Chronic Inflammation in Overweight Adults in a Randomized Placebo-Controlled Trial.

  Curr. Dev. Nutr., 5(2):nzab006. PubMed

• Ono-Ohmachi A, Yamada S, Uno S, Tamai M, Soga K, Nakamura S, Udagawa N, Nakamichi Y, Koide M, Morita Y, Takano T, Itoh T, Kakuta S, Morimoto C, Matsuoka S, Iwakura Y, Tomura M, Kiyono H, Hachimura S, Nakajima-Adachi H.

  Effector memory CD4 + T cells in mesenteric lymph nodes mediate bone loss in food-allergic enteropathy model mice, creating IL-4 dominance.

  Mucosal Immunol. PubMed

• Zhou Y, Qiu W, Wang Y, Wang R, Takano T, Li X, Zhu Z, Nakajima-Adachi H, Tanokura M, Hachimura S, Miyakawa T.

  β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis. Biomedicines.

  Biomedicines., 9(7):704. PubMed

• Bui TBC., Nosaki S., Kokawa M., Xu Y., Kitamura Y., Tanokura M., Hachimura S., Miyakawa T.

  Evaluation of spice and herb as phyto-derived selective modulators of human retinaldehyde dehydrogenases using a simple in vitro method. 

  Biosci Rep., 41(5):BSR20210491. PubMed

2020

原著論文

• Zhou Y., Takano T., Wang Y., Li X., Wang R., Wakatsuki Y., Nakajima-Adachi H., Tanokura M., Miyakawa T., Hachimura S.

  Intestinal regulatory T cell induction by β-elemene alleviates the formation of fat tissue-related inflammation.

  iScience, 24(1):101883. PubMed

• Takano T., Kotaki R., Park J., Yoshida T., Wakatsuki Y., Tanokura M., Miyakawa T., Takahashi K., Nakajima-Adachi H., Hachimura S.

  Age-dependent decrease in the induction of regulatory T cells is associated with decreased expression of RALDH2 in mesenteric lymphnode dendritic cells.

  Front. Immunol., 11:1555. PubMed

• Morita Y., Wang R., Li X., Muramatsu T., Ueda M., Hachimura S., Takahashi S., Miyakawa T., Tanokura M.

  Improved preparation of group-specific component (Gc) protein to derive macrophage activating factor.

  Protein Expr. Purif., 175:105714. PubMed

• Li X., Miyakawa T., Takano T., Nakajima-Adachi H., Tanokura M, Hachimura S.

  Induction of Oral Tolerance by Pepsin-Digested Gliadin Retaining T Cell Reactivity in a Mouse Model of Wheat Allergy.

  Int. Arch. Allergy Immunol., 181:446-455. PubMed

• Morinaga M., Nakajima-Adachi H., Hiraide E., Kitamura N., Kaminuma O., Hiroi T., Ohashi-Doi K., Hachimura S.

  Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy.

  Allergol. Int., 69:622-625. PubMed

• Takano T., Endo R., Wang Y., Nakajima-Adachi H., Hachimura S.

  Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells.

  Biosci. Microbiota Food Health, 39:39-44. PubMed

• Toshimitsu T., Gotou A., Sashihara T., Hachimura S., Shioya N., Suzuki S., Asami Y.

  Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial.

  Nutrients, 12(2):374. PubMed

2019

原著論文

• Toshimitsu T., Gotou A., Furuichi K., Hachimura S., Asami Y.

  Effects of 12-wk Lactobacillus plantarum OLL2712 treatment on glucose metabolism and chronic inflammation in prediabetic individuals: A single-arm pilot study.

  Nutrition, 58:175-180. PubMed

• Miyazato S., Tsuda M., Kishimoto Y., Nakajima-Adachi H., Hosono A.

  Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy.

  Biosci Microbiota Food Health, 38(3):89-95. PubMed

2018

原著論文

• Arai S., Iwabuchi N., Takahashi S., Xiao JZ., Abe F., Hachimura S.

  Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen- specific IgA secretion and induces follicular helper T cells in mice

  PLoS One, 13(6):e0199018. PubMed

• Ono-Ohmachi A., Nakajima-Adachi H., Morita Y., Kato K., Hachimura S.

  Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse.

  J. Dairy Sci., 101(3):1852-1863. PubMed

総説

• Hachimura S., Totsuka M., Hosono A.

  Immunomodulation by food: impact on gut immunity and immune cell function.

  Biosci. Biotechnol. Biochem. , 82(4):584-599. PubMed

2017

原著論文

• Hiraide E., Morinaga M., Hidaka H., Yamada S., Takeyama J., Kitamura N., Kaminuma O., Hiroi T., Du W., Ohashi-Doi K., Nakajima-Adachi H., Hachimura S.

  Oral administration of ovalbumin after sensitization attenuates symptoms in a mouse model of food allergic enteropathy

  Biosci. Biotechnol. Biochem., 81(10):1967-1972. PubMed

• 足立 (中嶋) はるよ

  食物アレルギー腸炎モデルマウスを用いた評価系の構築

  Establishment of a system to evaluate immune responses to egg white using a mouse model of food allergic enteropathy

  日本薬理学雑誌, 150(2):72-77. PubMed

• Shiokawa A., Kotaki R., Takano T., Nakajima-Adachi H., Hachimura S.

  Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells

  Immunology, 152(1):52-64. PubMed

• Jia H., Hanate M., Aw W., Itoh H., Saito K., Kobayashi S., Hachimura S., Fukuda S., Tomota M., Hasebe Y., Kato H.

  Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis

  Sci. Rep., 7:43993. PubMed

• Nakajima-Adachi H., Shibahara K., Fujimura Y., Takeyama J., Hiraide E., Kikuchi A., Murakami H., Hosono A., Nochi T., Wakatsuki Y., Shimojo N., Kaminogawa S., Sato R., Kiyono H., Hachimura S.

  Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization tolerance, and inflammation of food allergy

  PLoS One, 12(2):e0172795. PubMed

2016

原著論文

• Aoki-Yoshida A., Yamada K., Hachimura S., Sashihara T., Ikegami S., Shimizu M., Totsuka M.

  Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gaseri OLL2809 via Increase of Effector Regulatory T Cells

  PLos One, 11(7): e0158643 PubMed

2015

原著論文

• Kotaki R., Wajima SI., Shiokawa A., Hachimura S.

  Toll-like receptor 2 suppresses Toll-like receptor 9 responses in Peyer's patch dendritic cells

  Immunobiology, 220(6):734-43. PubMed

総説等

• 八村 敏志

  腸の機能と食品の作用

  臨床栄養, 126: 116-120.

その他

• 足立はるよ

  腸間膜リンパ節切除術のノウハウライセンス取得

  東京大学 管理番号: ノウハウ　K2514Y001 2015年7月30日

2014

原著論文

• Watanabe H., Toda M., Sekido H., Fujii T., Henle T., Hachimura S., Nakajima-Adachi H.

  Heat treatment of egg white controls allergic symptoms and induces oral tolerance to ovalbumin in a murine model of food allergy

  Mol. Nutr. Food Res., 58 (2): 394-404. PubMed

• Park J., Miyakawa T., Shiokawa A., Nakajima-Adachi H., Tanokura M., Hachimura S.

  Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid, and RALDH expression compared to young mice

  Biosci. Biotechnol. Biochem., 78 (6): 976-80. PubMed

• Hiraide E., Nakajima-Adachi H., Hachimura S.

  Oral Administration of T Cell Epitope Peptide Inhibits the Systemic IL-4 Response Elicited by an Egg-White Diet in a TCR Transgenic Mouse Model

  Biosci. Microbiota Food Health, 33 (1): 47-51. PubMed

• Shibahara K., Nakajima-Adachi H., Kaminuma O., Hiroi T., Mori A., Hachimura S.

  Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake

  Biosci. Microbiota Food Health, 33 (1): 41-6. PubMed

• Park J., Miyakawa T., Shiokawa A., Nakajima-Adachi H., Tanokura M., Hachimura S.

  Splenic stromal cells from aged mice produce higher levels of IL-6 compared to young mice

  Mediators Inflamm., 2014: 826987 PubMed

• Nakajima-Adachi H., Kikuchi A., Fujimura Y., Shibahara K., Makino T., Goseki-Sone M., Kihara-Fujioka M., Nochi T., Kurashima Y., Igarashi O., Yamamoto M., Kunisawa J., Toda M., Kaminogawa S., Sato R., Kiyono H., Hachimura S.

  Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy

  PLoS One, 9 (10): e107492 PubMed

• Kikuchi Y., Kunitoh-Asari A., Hayakawa K., Imai S., Kasuya K., Abe K., Adachi Y., Fukudome S., Takahashi Y., Hachimura S.

  Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice

  PLoS One, 9 (1): e86416 PubMed

総説等

• 八村 敏志

  腸管関連リンパ組織におけるストローマ細胞の役割

  臨床免疫・アレルギー科, 62: 14-6.

• 八村 敏志

  腸内細菌の認識と免疫・アレルギー

  G. I. Research, 22: 136-40.

• 八村 敏志

  腸管免疫―腸内フローラと免疫系の接点

  遺伝, 68: 328-31.

• 八村 敏志

  腸管免疫系に特徴的な細胞群による免疫応答誘導の腸内共生細菌と食品の作用

  化学と生物, 52: 814-8.

2013

原著論文

• Bohnen C., Wangorsch A., Schulke S., Nakajima-Adachi H., Hachimura S., SuzerY.,Schwantes A., Sutter G., Waibler Z., Reese G., Toda M., Scheurer S., ViethsS.

  Vaccination with recombinant modified vaccinia virus ankara prevents theonsetof intestinal allergy of mice

  Allergy, 68 (8): 1021-8. PubMed

• Tanioka A., Tanabe K., Hosono A., Kawakami H., Kaminogawa S., Tsubaki K., Hachimura S.

  Enhancement of intestinal immune function in mice by β-D-glucanfromAureobasidium pullulans ADK-34.

  Scand. J. Immunol., 78 (1): 61-8. PubMed

• Yanagibashi T., Hosono A., Oyama A., Tsuda M., Suzuki A., Hachimura S., Takahashi Y., Momose Y., Itoh K., Hirayama K., Takahashi K., Kaminogawa S.

  IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA productionin the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells

  Immunobiology, 218 (4): 645-51. PubMed

2012

原著論文

• Nakajima-Adachi H., Koike E, Totsuka M., Hiraide E., Wakatsuki Y., Kiyono H., Hachimura S.

  Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4+ T cells into the Th2 or Th1 phenotype.

  Biosci. Biotechnol. Biochem., 76 (10): 1979-81. PubMed

• Onodera T., Takahashi Y., Yokoi Y., Ato M., Kodama Y., Hachimura S., Kurosaki T., Kobayashi K.

  Memory B cells in the lung participate in protectivehumoralimmuneresponses topulmonary influenza virus reinfection.

  Proc. Natl. Acad. Sci. U S A., 109 (7): 2485-90. PubMed

総説等

• 八村 敏志

  腸管におけるIgA産生とCD3-IL-2R+ 細胞

  臨床免疫・アレルギー科, 58: 387-90.

• 八村 敏志

  腸管自然免疫系と腸内細菌

  臨床栄養, 120: 685-8.

2011

原著論文

• Hashiguchi M., Hachimura S., Ametani A., Sato T., Kojima H., Kumagai Y., Habu S., KobataT., Kaminogawa S.

  Naive CD4+T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.

  Immunol. Lett., 141 (1): 109-15. PubMed

• Burggraf M., Nakajima-Adachi H., Hachimura S., Ilchmann A., Pemberton AD., Kiyono H., Vieths S., Toda M.

  Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy.

  Mol. Nutr. Food Res., 55 (10): 1475-83 PubMed

• Hiramatsu Y., Hosono A., Konno T., Nakanishi Y., Muto M., Suyama A., Hachimura S., Sato R., Takahashi K., Kaminogawa S.

  Orally administered Bifidobacterium triggers immune responses following capture by CD11c+ cells in Peyer's patches and cecal patches

  Cytotechnology., 63 (3): 307-17. PubMed

• Ohashi T., Iizuka S., Shimada Y., Eto Y., Ida H., Hachimura S., Kobayashi H.

  Oral administration of recombinant human acid α-glucosidase reduces specific antibody formation against enzyme in mouse.

  Mol. Genet. Metab., 103 (1): 98-100. PubMed

総説等

• 塩河 亜弥, 八村 敏志

  経口免疫寛容の誘導とCD11b+細胞群

  臨床免疫・アレルギー科, 56 (3): 351-8.

• Shimizu M., Hachimura S.

  Gut as a target for functional food

  Trend. Food Sci. Technol., 22 (12), 646-50.

2010

原著論文

• Tsuda M., Hosono A., Yanagibashi T., Kihara-Fujioka M., Hachimura S., Itoh K., Hirayama K., Takahashi K., Kaminogawa S.

  Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen

  Immunol. Lett., 132, 45-52. PubMed

2009

原著論文

• Shiokawa A., Tanabe K., Tsuji NM., Sato R., Hachimura S.

  IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10production ofT cells are induced in oral tolerance.

  Immunol. Lett., 125: 7-14. PubMed

• Tsuda M., Hosono A., Yanagibashi T., Hachimura S., Hirayama K., Umesaki Y., Itoh K., Takahashi K., Kaminogawa S.

  Intestinal Bifidobacterium association in germ-free T cell receptor transgenic mice down-regulates dietary antigen-specific immune responses of the small intestine but enhances those of the large intestine.

  Immunobiology, 214 (4): 279-89. PubMed

• Iwabuchi N., Takahashi N., Xiao JZ., Yonezawa S., Yaeshima T., Iwatsuki K., Hachimura S.

  Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.

  FEMS Immunol. Med. Microbiol., 55 (3): 324-34. PubMed

• Yanagibashi T., Hosono A., Oyama A., Tsuda M., Hachimura S., Takahashi Y., Itoh K., Hirayama K., Takahashi K., Kaminogawa S.

  Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression in B cells in murine Peyer's patches.

  Biosci. Biotechnol. Biochem., 73 (2): 372-7. PubMed

総説等

• 塩河亜弥, 八村敏志

  経口免疫寛容誘導におけるパイエル板樹状細胞の役割

  臨床免疫・アレルギー科, 52: 529-37.

2008

原著論文

• Kanzato H., Fujiwara S., Ise W., Kaminogawa S., Sato R., Hachimura S.

  Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells.

  Immunobiology, 213: 399-408. PubMed

総説等

• 八村敏志

  ヌクレオチドやポリフェノールと腸管免疫機能

  栄養評価と治療, 25: 42-5.

2007

原著論文

• Tomita K., Nagura T., Okuhara Y., Nakajima-Adachi H., Shigematsu N., Aritsuka T., Kaminogawa S., Hachimura S.

  Dietary melibiose regulates Th cell response and enhances the induction of oral tolerance.

  Biosci. Biotechnol. Biochem., 71: 2774-80. PubMed

• Tsuda M, Hosono A, Yanagibashi T, Hachimura S, Hirayama K, Itoh K,TakahashiK,Kaminogawa S.

  Prior stimulation of antigen-presenting cells with Lactobacillus regulates excessive antigen-specific cytokine responses in vitro when compared with Bacteroides.

  Cytotechnology, 55: 89-101. PubMed

総説等

• 梅田幸子, 八村敏志

  IgA産生におけるCD3-IL-2R+パイエル板細胞の役割

  臨床免疫・アレルギー科, 47: 633-9.

• 八村敏志

  乳酸菌の免疫調節機能

  Jpn. J. Lactic Acid Bact., 18: 54-7.