発表論文

2024

Yohei Kondo, Yutaro Saito, Tomohiro Seki, Yoichi Takakusagi, Norikazu Koyasu, Keita Saito, Jumpei Morimoto, Hiroshi Nonaka, Koichiro Miyanishi, Wataru Mizukami, Makoto Negoro, Abdelazim E. Elhelaly, Fuminori Hyodo, Masayuki Matsuo, Natarajan Raju, Rolf E. Swenson, Murali C. Krishna, Kazutoshi Yamamoto, Shinsuke Sando*
"Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides"
Science Adv. 2024, 10, eadp2533., DOI: 10.1126/sciadv.adp2533
ChemRxiv 2022, DOI: 10.26434/chemrxiv-2022-tfkk1.

Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shumpei I. Kubota, Hiroyuki Yatabe, Minoru Kobayashi, Hiroshi Harada, Kazuki Tainaka, and Shinsuke Sando*
"Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging"
Science Adv. 2024, 10, eado8471., DOI: 10.1126/sciadv.ado8471
Selected as the ONLINE cover.
ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-sdjss

Marin Yokomine, Jumpei Morimoto,* Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, Satoru Nagatoishi, Kouhei Tsumoto and Shinsuke Sando*
"A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2"
Chem. Sci., 2024, 15, 7051–7060. DOI: 10.1039/D4SC01540A.
Selected as 2024 ChemSci Pick of the Week Collection, HOT Article Collection, Chemical Science Covers.

Kiyofumi Takaba, Saori Maki-Yonekura, Ichiro Inoue, Kensuke Tono, Yasuhiro Fukuda, Yota Shiratori, Yiying Peng, Jumpei Morimoto, Satoru Inoue, Toshiki Higashino, Shinsuke Sando, Tatsuo Hasegawa, Makina Yabashi, and Koji Yonekura*
"Comprehensive Application of XFEL Microcrystallography for Challenging Targets in Various Organic Compounds"
J. Am. Chem. Soc., 2024, 146, 5872–5882. DOI: 10.1021/jacs.3c11523.

Daichi M. Sakamoto, Iori Tamura, Bo Yi, Sho Hasegawa, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shimpei I. Kubota, Hiroshi Harada, Kenjiro Hanaoka, Masayasu Taki, Masaomi Nangaku, Kazuki Tainaka*, and Shinsuke Sando*
"Whole-body and whole-organ 3D imaging of hypoxia using activatable covalent fluorescent probe compatible with tissue clearing"
ACS Nano 2024, 18, 5167–5179. DOI: 10.1021/acsnano.3c12716
ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-bride.

Ayaka Hayashi, Yuki Goto,* Yutaro Saito, Hiroaki Suga, Jumpei Morimoto,* and Shinsuke Sando*
"Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides"
Chem. Commun. 2024, 60, 9436–9439. DOI: 10.1039/D4CC03179B

Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shinsuke Sando*
"Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction"
Anal. Sci., 2024, 40, 1061–1070. DOI: 10.1007/s44211-024-00520-y

Yuyuan Chen, Kunihiko Morihiro*, Yui Nemoto, Akito Ichimura, Ryosuke Ueki, Shinsuke Sando, Akimitsu Okamoto*
"Selective Inhibition of Cancer Cell Migration Using a pH-Responsive Nucleobase-Modified DNA Aptamer"
Chem. Sci., 2024, in press.

Yizhou Dai, Natsuko F. Inagaki, Ryosuke Ueki, Shinsuke Sando, Kiyoshi Hasegawa, Taichi Ito*
"Hepatocyte Growth Factor DNA Aptamer for Prevention of Postoperative Peritoneal Adhesion via Enhancement of Fibrinolysis and Inhibition of Mesothelial Mesenchymal Transition"
ACS Appl. Bio. Mater., 2024, 7, 4679–4689. DOI: 10.1021/acsabm.4c00507

2023

Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E. Townsend, Colin N. Kelly, Matthew R. Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, Takumi Ueda, Koh Takeuchi, Masatake Sugita, Yutaka Akiyama*, Scott R. Lokey*, Jumpei Morimoto* and Shinsuke Sando*
"Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides"
Nature Commun. 2023, 14, 1416. DOI: 10.1038/s41467-023-36978-z
東大プレスリリース、 JSTプレスリリース、日本経済新聞

Hanrui Liu, Toni Baeumler, Kai Nakamura, Yuga Okada, Seojung Cho, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki* and Shinsuke Sando*
"An Engineered Synthetic Receptor–Aptamer Pair for an Artificial Signal Transduction System"
ACS Nano 2023, 17, 9039–9048. DOI: 10.1021/acsnano.2c11744

Takahiro Ono, Kazuhito V. Tabata, Yuki Goto, Yutaro Saito, Hiroaki Suga, Hiroyuki Noji, Jumpei Morimoto* and Shinsuke Sando*
"Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: Penetration speed of cyclosporin A across lipid bilayers"
Chem. Sci. 2023, 14, 345–349. DOI: 10.1039/D2SC05785A

Shinsuke Sando*
"Development of Hyperpolarized NMR Molecular Probes for Biological Applications"
Bull. Chem. Soc. Jpn. (Award Account) 2023, 96, 995–1002. DOI: 10.1246/bcsj.20230161

Takahiro Ono, Kazuhito V. Tabata, Hiroyuki Noji, Jumpei Morimoto* and Shinsuke Sando*
"Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers"
RSC Adv. 2023, 13, 8394–8397. DOI: 10.1039/D3RA01358H

Junya Hoshiyama, Yuga Okada, Seojung Cho, Ryosuke Ueki* and Shinsuke Sando*
"Apt-clean: Aptamer-mediated cleavage of extracellular antigen for the inhibition of membrane protein functions"
Biomater. Sci. 2023, 11, 445–449. DOI: 10.1039/D2BM01695H

Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, Masashi Muramatsu, Melvin Pan, Rika Tsuchida, Yoshihiro Matsumura, Hideyuki Yanai, Hiroshi Takano, Ryoji Yao, Shinsuke Sando, Masabumi Shibuya, Juro Sakai, Tatsuhiko Kodama, Hiroyasu Kidoya, Teppei Shimamura, Tsuyoshi Osawa*
"Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth"
EMBO J. 2023, e114032, DOI: 10.15252/embj.2023114032

Koji Kadota, Toshiki Mikami, Ai Kohata, Jumpei Morimoto, Shinsuke Sando, Kohsuke Aikawa*, Takashi Okazoe
"Synthesis of Short Peptides with Perfluoroalkyl Side Chains and Evaluation of Their Cellular Uptake Efficiency"
ChemBioChem 2023, e202300374, DOI: 10.1002/cbic.202300374

2022

Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna,* Shinsuke Sando*
"Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo"
Science Adv. 2022, 8, eabj2667. DOI: 10.1126/sciadv.abj2667
東大プレスリリース、 QSTプレスリリース、日本経済新聞

Marin Yokomine, Jumpei Morimoto,* Yasuhiro Fukuda, Yota Shiratori, Daisuke Kuroda, Takumi Ueda, Koh Takeuchi, Kouhei Tsumoto, and Shinsuke Sando*
"Oligo(N-methylalanine) as a Peptide-Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites"
Angew. Chem. Int. Ed. 2022, 61, e202200119. DOI: 10.1002/anie.202200119.

Jungyeon Kim, Hiroka Kobayashi, Marin Yokomine, Yota Shiratori, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto* and Shinsuke Sando*
"Residue-Based Program of a ß-Peptoid Twisted Strand Shape via a Cyclopentane Constraint"
Org. Biomol. Chem. 2022, 20, 6994–7000. DOI: 10.1039/d2ob01300b

Alice Radaelli, Daniel Ortiz, Alessia Michelotti, Maxime Roche, Ryunosuke Hata, Shinsuke Sando, Olivier Bonny, Rolf Gruetter, and Hikari A. I. Yoshihara*
"Hyperpolarized (1-13C)Alaninamide Is a Multifunctional In Vivo Sensor of Aminopeptidase N Activity, pH, and CO2"
ACS Sens. 2022, 7, 2987–2994. DOI: 10.1021/acssensors.2c01203

2021

Momoko Akiyama‡, Ryosuke Ueki‡*, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando*
"DNA-based Synthetic Growth Factor Surrogates with Fine-tuned Agonism"
Angew. Chem. Int. Ed. 2021, accepted, DOI: 10.1002/anie.202105314.
‡These authors contributed equally to this work.
Selected as a Frontispiece.
A press release was issued.

Yohei Kondo, Hiroshi Nonaka, Yoichi Takakusagi, Shinsuke Sando*
"Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging"
Angew. Chem. Int. Ed. 2021, 60, 2–23. [Review] DOI: 10.1002/anie.201915718

Akihiro Eguchi, Ayaka Ueki, Junya Hoshiyama, Keiko Kuwata, Yoko Chikaoka, Takeshi Kawamura, Satoru Nagatoishi, Kouhei Tsumoto, Ryosuke Ueki*, and Shinsuke Sando*
"A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells"
JACS Au 2021, 1, 578–585. DOI: 10.1021/jacsau.0c00121.

Tomoki Ota‡, Akinobu Senoo‡, Masumi Shirakawa‡, Hiroshi Nonaka, Yutaro Saito, Sho Ito, Go Ueno, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando*
"Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate"
iScience 2021, 24, 102036. DOI: 10.1016/j.isci.2021.102036.
‡These authors contributed equally to this work.

Yasuhiro Fukuda, Marin Yokomine, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto*, Shinsuke Sando*
"Peptoid-Based Reprogrammable Template for Cell-Permeable Inhibitors of Protein–Protein Interactions"
Chem. Sci. 2021, 12, 13292–13300. DOI: 10.1039/D1SC01560E
Selected as a 2021 Chemical Science HOT Article Collection
Selected as a Inside Front Cover
Introduced at Chemistry World

Yuri Hayata, Ryosuke Ueki, Shinsuke Sando
"Feeder-Free Human Induced Pluripotent Stem Cell Culture Using a DNA Aptamer-Based Mimic of Basic Fibroblast Growth Factor"
Methods Mol. Biol. 2021, 2312, 301–305. [Book chapter] DOI: 10.1007/978-1-0716-1441-9_18.

Ryosuke Ueki*, Shota Hayashi, Masaya Tsunoda, Momoko Akiyama, Hanrui Liu, Tasuku Ueno, Yasuteru Urano, and Shinsuke Sando*
"Nongenetic control of receptor signaling dynamics with a DNA-based optochemical tool"
Chem. Commun. 2021, 57, 5969–5972. DOI: 10.1039/D1CC01968F.

Yuki Hosono, Jumpei Morimoto,* and Shinsuke Sando*
"A Comprehensive Study on the Effect of Backbone Stereochemistry of a Cyclic Hexapeptide on Membrane Permeability and Microsomal Stability"
Org. Biomol. Chem. 2021, 19, 10326–10331. DOI: 10.1039/D1OB02090K.

Takahiro Ono, Kohsuke Aikawa, Takashi Okazoe, Jumpei Morimoto*, and Shinsuke Sando*
"Methyl to trifluoromethyl substitution as a strategy to increase membrane permeability of short peptides"
Org. Biomol. Chem. 2021, 19, 9386–9389. DOI: 10.1039/D1OB01565F.

Yohei Kondo, Yutaro Saito, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Tatsuya Nishihara, Marino Itoda, Hiroshi Nonaka, Masayuki Matsuo, and Shinsuke Sando*
"Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state"
RSC Adv. 2021, 11, 37011–37018. DOI: 10.1039/D1RA07343E.

Junya Hoshiyama, Yuga Okada, Yuri Hayata, Akihiro Eguchi, Ryosuke Ueki*, and Shinsuke Sando*
"Characterization of a DNA Aptamer with High Specificity toward Fibroblast Growth Factor Receptor 1"
Chem. Lett. 2021, DOI: 10.1246/cl.210505.

Ai Kohata, Ryosuke Ueki, Kou Okuro*, P. K. Hashim, Shinsuke Sando, and Takuzo Aida*
"Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins"
J. Am. Chem. Soc. 2021, 143, 13937–13943. DOI: 10.1021/jacs.1c06816
Highlighted in JACS Spotlights

Akinobu Senoo, Sho Ito, Satoru Nagatoishi*, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, and Kouhei Tsumoto*
"Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion"
Commun. Biol. 2021, 4, 1041. DOI: 10.1038/s42003-021-02575-3.

2020

Ryosuke Ueki‡*, Satoshi Uchida‡, Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, and Shinsuke Sando*
"A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application"
Science Advances, 2020, 6, eaay2801. DOI: 10.1126/sciadv.aay2801
‡These authors contributed equally to this work.
A press release was issued.

Jumpei Morimoto,‡* Jungyeon Kim,‡ Daisuke Kuroda, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando*
"Per-residue Program of Multiple Backbone Dihedral Angles of β-Peptoids via Backbone Substitutions"
J. Am. Chem. Soc. 2020, 142, 2277–2284. DOI: 10.1021/jacs.9b10496
‡These authors contributed equally to this work.

Takafumi Furuhata, Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi,* Ryosuke Ueki, and Shinsuke Sando*
"Key aurophilic motif for robust quantum-tunneling-based characterization of a nucleoside analogue marker"
Chem. Sci. 2020, 11, 10135-10142. DOI: 10.1039/x0xx00000x

Takafumi Furuhata, Takahito Ohshiro, Yuichi Izuhara, Tomoaki Suzuki, Ryosuke Ueki, Masateru Taniguchi, and Shinsuke Sando*
"Chemical Labeling-Assisted Detection of Nucleobase Modifications by Quantum Tunneling-Based Single Molecule Sensing"
ChemBioChem 2020, 21, 335–339. DOI:10.1002/cbic.201900422

Jumpei Morimoto* and Shinsuke Sando*
"Peptoids with Substituents on the Backbone Carbons as Conformationally Constrained Synthetic Oligoamides"
J. Synth. Org. Chem., Jpn. 2020, 78, 1076-1084. [Review] DOI: 10.5059/yukigoseikyokaishi.78.1076

Alice Radaelli, Hikari A. I. Yoshihara, Hiroshi Nonaka, Shinsuke Sando, Jan Henrik Ardenkjaer-Larsen, Rolf Gruetter, and Andrea Capozzi
"13C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid-Effect"
J. Phys. Chem. Lett. 2020, 11, 6873-6879. DOI: 10.1021/acs.jpclett.0c01473

Georgios Batsios#, Chloé Najac#, Peng Cao, Pavithra Viswanath, Elavarasan Subramani, Yutaro Saito, Anne Marie Gillespie, Hikari A.I. Yoshihara, Peder Larson, Shinsuke Sando, Sabrina M. Ronen*
"In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-13C]glycine"
Sci. Rep. 2020, 10, 6244. DOI: 10.1038/s41598-020-63160-y
#These authors contributed equally to this work.

2019

Hiroshi Nonaka,* Yuki Nakanishi,‡ Satoshi Kuno,‡ Tomoki Ota,‡ Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi,Kouhei Tsumoto, Shinsuke Sando*
"Design Strategy for Serine Hydroxymethyltransferase Probes Based on Retro-Aldol-Type Reaction"
Nature Commun. 2019, 10, 876. DOI: 10.1038/s41467-019-08833-7

Jumpei Morimoto,‡* Yasuhiro Fukuda,‡ Daisuke Kuroda, Takumu Watanabe, Fumihiko Yoshida, Mizue Asada, Toshikazu Nakamura, Akinobu Senoo, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando*
"A Peptoid with Extended Shape in Water"
J. Am. Chem. Soc. 2019, 141, 14612-14623. DOI: 10.1021/jacs.9b04371
‡These authors contributed equally to this work.
Selected as a Supplementary Cover Art.
Part of the work was previously posted on ChemRxiv

Marino Itoda, Yuki Naganawa,* Makoto Ito, Hiroshi Nonaka, and Shinsuke Sando*
"Structural exploration of rhodium catalysts and their kinetic studies for efficient parahydrogen-induced polarization by side arm hydrogenation"
RSC Advances 2019, 9, 18183-18190. DOI: 10.1039/C9RA02580D

Takafumi Furuhata, Takahito Ohshiro, Gaku Akimoto, Ryosuke Ueki, Masateru Taniguchi* and Shinsuke Sando*
"Highly Conductive Nucleotide Analogue Facilitates Base-Calling in Quantum Tunneling-Based DNA Sequencing"
ACS Nano 2019, 13, 5028-5035. DOI: 10.1021/acsnano.9b01250

Jumpei Morimoto,* Rei Amano, Takahiro Ono, and Shinsuke Sando*
"A Parallel Permeability Assay of Peptides across Artificial Membrane and Cell Monolayers Using a Fluorogenic Reaction"
Org. Biomol. Chem. 2019, 17, 2887-2891. DOI: 10.1039/c9ob00133f

Ryosuke Ueki,* Saki Atsuta, Ayaka Ueki, Junya Hoshiyama, Jingyue Li, Yohei Hayashi and Shinsuke Sando*
"DNA Aptamer Assemblies as Fibroblast Growth Factor Mimics and Their Application in Stem Cell Culture"
Chem. Commun. 2019, 55, 2672-2675. DOI: 10.1039/c8cc08080a

Rina Mogaki, Kou Okuro,* Ryosuke Ueki, Shinsuke Sando, and Takuzo Aida*
"Molecular Glue that Spatiotemporally Turns on Protein–Protein Interactions"
J. Am. Chem. Soc. 2019, 141, 8035-8040. DOI: 10.1021/jacs.9b02427

Kenichiro Tateichi*, Makoto Negoro, Hiroshi Nonaka, Akinori Kagawa, Shinsuke Sando, Satoshi Wada, Masahiro Kitagawa, and Tomohiro Uesaka
"Dynamic nuclear polarization with photo-excited triplet electrons using 6,13-diphenylpentacene"
Phys. Chem. Chem. Phys. 2019, 21, 19737-19741. DOI: 10.1039/C9CP00977A

2018

Ryosuke Ueki,* Saki Atsuta, Ayaka Ueki, and Shinsuke Sando*
"Nongenetic Reprogramming of the Ligand Specificity of Growth Factor Receptors by Bispecific DNA Aptamers"
J. Am. Chem. Soc. 2017, 139, 6554-6557.

Tatsuya Nishihara*, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, and Tomoyoshi Soga*
"Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection"
Chem. Commun. 2018, 54, 11745-11748.

Jumpei Morimoto,* Yuki Hosono, and Shinsuke Sando*
"Isolation of a peptide containing D-amino acid residues that inhibits the α-helix-mediated p53–MDM2 interaction from a one-bead one-compound library"
Bioorg. Med. Chem. Lett. 2018, 28, 231-234. DOI: 10.1016/j.bmcl.2018.01.001

Yuki Imakura, Hiroshi Nonaka,* Yoichi Takakusagi, Kazuhiro Ichikawa, Nesmine R. Maptue, Alexander M. Funk, Chalermchai Khemtong, and Shinsuke Sando*
"Rational design of [13C,D14]tert-butylbenzene as a scaffold structure for designing long-lived hyperpolarized 13C probes"
Chem. Asian J. 2018, 13, 280-283.

2017

Jumpei Morimoto,* Yasuhiro Fukuda, and Shinsuke Sando*
"Solid-Phase Synthesis of β-Peptoids with Chiral Backbone Substituents Using Reductive Amination"
Org. Lett. 2017, 19, 5912-5915. DOI: 10.1021/acs.orglett.7b02909

Tatsuya Nishihara, Yutaka Kameyama, Hiroshi Nonaka, Yoichi Takakusagi, Fuminori Hyodo, Kazuhiro Ichikawa, and Shinsuke Sando*
"A Strategy to Design Hyperpolarized ¹³C Magnetic Resonance Probes Using [1-¹³C]α-Amino Acid as a Scaffold Structure"
Chem. Asian. J. 2017, 12, 949-953.

Hiroshi Nonaka,* Masashi Hirano, Yuki Imakura, Yoichi Takakusagi, Kazuhiro Ichikawa, and Shinsuke Sando*
"Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State"
Sci. Rep. 2017, 7, 40104.

2016

Tatsuya Nishihara,# Hikari A. I. Yoshihara,# Hiroshi Nonaka, Yoichi Takakusagi, Fuminori Hyodo, Kazuhiro Ichikawa, Emine Can, Jessica A. M. Bastiaansen, Yuhei Takado, Arnaud Comment,* and Shinsuke Sando*
# These authors contributed equally to this work.
"Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized 13C-Labeled Molecular Probe"
Angew. Chem. Int. Ed. 2016, 55, 10626-10629.

Ryunosuke Hata, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, and Shinsuke Sando*
"Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity"
Angew. Chem. Int. Ed. 2016, 55, 1765-1768.

Ryosuke Ueki, Ayaka Ueki, Naoto Kanda, and Shinsuke Sando*
"Oligonucleotide-based Mimetics of Hepatocyte Growth Factor"
Angew. Chem. Int. Ed. 2016, 55, 579-582.
Selected as Hot Paper

Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama*, and Teruyuki Kondo*
"Magnetic Resonance Imaging of Tumor with a Self-Traceable Phosphorylcholine Polymer."
J. Am. Chem. Soc. 2015, 137, 799-806.

Akira Tsuchiya, Siti N. Hashim, Shoko Ise, Takafumi Furuhata, Kiyohiko Kawai, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya, and Shinsuke Sando*
"BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells"
Anal. Sci. 2016, 32, 543-547.
Selected as Hot Article

Hisatsugu Yamada, Tetsuro Kameda, Yu Kimura, Hirohiko Imai, Tetsuya Matsuda, Shinsuke Sando, Akio Toshimitsu, Yasuhiro Aoyama*, and Teruyuki Kondo*
"13C/15N-Enriched L-Dopa as a Triple-Resonance NMR Probe to Monitor Neurotransmitter Dopamine in the Brain and Liver Extracts of Mice"
ChemistryOpen 2016, 5, 125-128.

2015

Siti Norulhuda Hashim, Akira Tsuchiya, Noriho Kamiya, and Shinsuke Sando*
"A Single Fluorophore-labeled Aptamer Sensor for the Detection of Interferon Gamma"
Chem. Lett., 2015, 44, 1670-1672.

Ryunosuke Hata, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, and Shinsuke Sando*
"Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ion."
Chem. Commun. 2015, 51, 12290-12292.

Hiroshi Nonaka, Qi An, Fuminori Sugihara, Tomohiro Doura, Akira Tsuchiya, Yoshichika Yoshioka, and Shinsuke Sando*
"Phenylboronic acid-based (19)F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change."
Anal. Sci. 2015, 31, 331-335.

2014以前

Ryosuke Ueki, and Shinsuke Sando*
"A DNA aptamer to c-Met inhibits cancer cell migration."
Chem. Commun. 2014, 50, 13131-13134.

Tatsuya Nishihara, Hiroshi Nonaka, and Shinsuke Sando*
"Design of Triple-resonance NMR Reporter Assay."
Chem. Lett. 2014, 43, 1873-1875.

Tomohiro Doura, Ryunosuke Hata, Hiroshi Nonaka, Fuminori Sugihara, Yoshichika Yoshioka, and Shinsuke Sando*
"An adhesive 19F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment."
Chem. Commun. 2013, 49, 11421-11423.

Hiroshi Nonaka, Ryunosuke Hata, Tomohiro Doura, Tatsuya Nishihara, Keiko Kumagai, Mai Akakabe, Masashi Tsuda, Kazuhiro Ichikawa, and Shinsuke Sando*
"A platform for designing hyperpolarized magnetic resonance chemical probes."
Nature Commun. 2013, 4, Article Number: 2411, doi: 10.1038/ncomms3411.

Takeshi Tokunaga, Kohei Kuwahata, Shinsuke Sando*
"Systematic Exploration of Lipophilic Tags That Allow Efficient Anchoring of Aptamers to Live Cell Surfaces."
Chem. Lett. 2013, 42, 127-129.

Tomohiro Doura, Ryunosuke Hata, Hiroshi Nonaka, Kazuhiro Ichikawa, and Shinsuke Sando*
"Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit."
Angew. Chem. Int. Ed. 2012, 51, 10114-10117.

Ryosuke Ueki, Koya Yamaguchi, Hiroshi Nonaka, and Shinsuke Sando*
"1H-NMR Probe for In Situ Monitoring of Dopamine Metabolism and Its Application to Inhibitor Screening."
J. Am. Chem. Soc. 2012, 134, 12398-12401.

Takeshi Tokunaga, Shigeyuki Namiki, Katsuhiro Yamada, Takahiro Imaishi, Hiroshi Nonaka, Kenzo Hirose, and Shinsuke Sando*
"Cell Surface-Anchored Fluorescent Aptamer Sensor Enables Imaging of Chemical Transmitter Dynamics."
J. Am. Chem. Soc. 2012, 134, 9561-9564.

Hisatsugu Yamada, Keigo Mizusawa, Ryuji Igarashi, Hidehito Tochio, Masahiro Shirakawa, Yasuhiko Tabata, Yu Kimura, Teruyuki Kondo, Yasuhiro Aoyama,* and Shinsuke Sando*
"Substrate/Product-Targeted NMR Monitoring of Pyrimidine Catabolism and Its Inhibition by a Clinical Drug."
ACS Chem. Biol. 2012, 7, 535-542.

Tatsuya Nishihara, Hiroshi Nonaka, Tatsuya Naganuma, Kazuhiro Ichikawa, Shinsuke Sando*
"Mouse Lactate Dehydrogenase X: A Promising Magnetic Resonance Reporter Protein Using Hyperpolarized Pyruvic Acid Derivative Y."
Chem. Sci. 2012, 3, 800-806.

Tomohiro Doura, Hiroshi Nonaka, Shinsuke Sando*
"Atom Arrangement Strategy for Designing Turn-On 1H Magnetic Resonance Probe: Dual Activatable Probe for Multimodal Detection of Hypochlorite."
Chem. Commun. 2012, 48, 1565-1567.

Atsushi Ogawa,* Masayoshi Hayami, Shinsuke Sando,* and Yasuhiro Aoyama
"A Concept for Selection of Codon-Suppressor tRNAs Based on Read-Through Ribosome Display in an In Vitro Compartmentalized Cell-Free Translation System."
J. Nucleic Acids 2012, Article ID 538129.

Koya Yamaguchi, Ryosuke Ueki, Hiroshi Nonaka, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando*
"Design of Chemical Shift-Switching 19F Magnetic Resonance Imaging Probe for Specific Detection of Human Monoamine Oxidase A"
J. Am. Chem. Soc. 2011, 133, 14208-14211.

Koya Yamaguchi, Ryosuke Ueki, Hisatsugu Yamada, Yasuhiro Aoyama, Hiroshi Nonaka, Shinsuke Sando*
"In situ analysis of [8-13C-7-15N]-double-labelled theophylline by triple resonance NMR technique"
Anal. Methods 2011, 3, 1664-1666.

Shinsuke Sando*
"Design of Functional Nucleic Acid Systems for Biomolecular Analysis"
Bull. Chem. Soc. Jpn. 2011, 84, 133-140.
Award Account for The Chemical Society of Japan Award for Young Chemists

Tomohiro Doura, An Qi, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando*
"p-Aminophenyl Alkyl Ether-based 19F MRI Probe for Specific Detection and Imaging of Hypochlorite Ion"
Chem. Lett. 2011, 12, 1357-1359.

Tomohiro Tsuji, Katsuya Gonda, Yasuhiro Aoyama,* Takeshi Tokunaga, and Shinsuke Sando*
"Inhibitor-Substituted BODIPY as a Turn-on Fluorescence Probe for Enzymes"
Chem. Lett. 2011, 40, 1275-1277.

Keigo Mizusawa, Ryuji Igarashi, Kosei Uehira, Yoshimasa Takafuji, Yasuhiko Tabata, Hidehito Tochio, Masahiro Shirakawa,* Shinsuke Sando,* Yasuhiro Aoyama*
"Turn-On Detection of Targeted Biochemical Reactions by Triple Resonance NMR Analysis Using Isotope-labeled Probe"
Chem. Lett. 2010, 39, 926-928.
Selected as Editor's Choice

Chika Furutani, Kazuki Shinomiya, Yasuhiro Aoyama,* Katsuhiro Yamada, and Shinsuke Sando*
"Modular Blue Fluorescent RNA Sensors for Label-Free Detection of Target Molecules"
Mol. Biosystems 2010, 6, 1569-1571.
Selected in Emerging Investigators Issue

Hiroki Masu, Atsushi Narita, Takeshi Tokunaga, Masayoshi Ohashi, Yasuhiro Aoyama,* and Shinsuke Sando*
"An activatable siRNA probe: trigger-RNA-dependent activation of RNAi function"
Angew. Chem. Int. Ed. 2009, 48, 9481-9483.
Selected as Hot Paper

Keigo Mizusawa, Kenji Abe, Shinsuke Sando,* and Yasuhiro Aoyama*
"Synthesis of Puromycin Derivatives with Backbone-Elongated Substrates and Associated Translation Inhibitory Activities"
Shinsuke Sando,* Atsushi Narita, Masayoshi Hayami and Yasuhiro Aoyama*
"Transcription Monitoring Using Fused RNA with a Dye-Binding Light-Up Aptamer as a Tag: A Blue Fluorescent RNA"
Chem. Commun. 2008, 3858-3860.
Selected as Hot Article and Inside Cover

Shinsuke Sando,* Hiroki Masu, Chika Furutani and Yasuhiro Aoyama*
"Enzymatic N-methylaminoacylation of tRNA using chemically misacylated AMP as a substrate"
Org. Biomol. Chem. 2008, 6, 2666-2668.

Shinsuke Sando,* Atsushi Narita, Masayoshi Hayami, and Yasuhiro Aoyama*
"Tuning the Hoechst Dye into Color-changing Fluorescent pH Indicator in an Acidic Range"
Chem. Lett. 2008, 37, 246-247.
Shinsuke Sando,* Atsushi Narita, Yasuhiro Aoyama*
"Light-Up Hoechst-DNA Aptamer Pair: Generation of an Aptamer-Selective Fluorophore from a Conventional DNA-Staining Dye"
ChemBioChem 2007, 8, 1795-1803.

Shinsuke Sando,* Kenji Abe, Nobuhiko Sato, Toshihiro Shibata, Keigo Mizusawa, and Yasuhiro Aoyama*
"Unexpected Preference of the E. coli Translation System for Ester-Bond During Incorporation of Backbone-Elongated Substrates"
J. Am. Chem. Soc. 2007, 129, 6180-6186.

Atsushi Narita, Kazumasa Ogawa, Shinsuke Sando,* Yasuhiro Aoyama*
"Cis-regulatory hairpin-shaped mRNA encoding a reporter protein: catalytic sensing of nucleic acid sequence at single nucleotide resolution"
Nature Protocols 2007, 2, 1105-1116.

Shinsuke Sando,* Atsushi Ogawa, Teruyuki Nishi, Masayoshi Hayami, Yasuhiro Aoyama*
"In Vitro Selection of RNA Aptamer Against Escherichia Coli Release Factor 1"
Bioorg. Med. Chem. Lett. 2007, 17, 1216-1220.

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