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Our Targets

We are studying on chemistry and life science of

nucleic acid methylation/demethylation using new chemical probes

intracellular RNA behavior using special chemical probes

chromatins consisting of chemically synthesized DNA and histones

single-cell functions through trapping and release of special cells

chemical protection from protein aggregation

aggregation of functional oligonucleotides in a cell

nucleic acid delivery through chemical functionalization

proto-nucleic acids built under prebiotic environments

How are our bodies created from atoms and molecules? We systematically investigate how the atoms and building blocks of biopolymers (nucleic acids and proteins) participate in biological phenomena, introducing synthetic chemistry-based ideas into biological and genetic studies. Research in our group is concerned with diverse aspects of the design and function of biopolymers on an atomic scale. The focus is on the design, synthesis and physical properties of new, man-made biopolymers with various special functions. Also included is the design of unprecedented organic chemical systems for recognizing, transforming and visualizing a single component or atom in biopolymers of interest. These researches are the fundamental studies reflecting the essence of life science on an atomic scale and the material-developing studies to get useful functional materials for the latest studies on life sciences and medical technologies. The lab employs a multidisciplinary approach involving organic synthesis, photophysical chemistry, state-of-the-art spectroscopy, and biological assays to address new approaches to the interface between synthetic chemistry and life science. Current projects include:

  1. Synthesis of ‘superbiopolymers’ containing functional nucleotides and amino acids for elucidation of gene expression function.
  2. Construction of new chemical platforms for collecting specific cells and analyzing cell-cell interactions at the single cell level.
  3. Drug design, cell introduction, and functional analysis based on new chemical ideas.
  4. Chemical exploration of ‘proto-nucleic acids’ under prebiotic conditions.

Collection of Works

 

Research Category List

Bioorganic Chemistry Organic Synthesis Nucleic Acid Chemistry Chemical Protein Engineering Cell Immobilization
In-Cell Organic Chemistry Live Cell Imaging Epigenetics Cell interaction Raman Spectroscopy
Origin of Life Photodynamic Therapy Dye design      

Bioorganic Chemistry

Organic Synthesis

Nucleic Acid Chemistry

Chemical Protein Engineering

Cell Immobilization

In-Cell Organic Chemistry

Live Cell Imaging

Epigenetics

Cell interaction

Raman Spectroscopy

Origin of Life

Photodynamic Therapy

Dye design

How to join us

Department of Chemistry and Biotechnology (MS/PhD integrated program)

To enroll in the Graduate School of Engineering as a graduate student, you are required to successfully pass an entrance examination.
See the website of the Department of Chemistry and Biotechnology.

http://www.chembio.t.u-tokyo.ac.jp/e/exam.html

Okamoto laboratory strongly encourages you to take the exam of the MS/PhD integrated program. First of all, please contact Okamoto after checking Okamoto’s papers.

Department of Advanced Interdisciplinary Studies (PhD course, no course for master degree)

The course provides mid-career persons with the opportunity to carry out doctoral studies in the university environment. Before requesting application forms, you are advised to contact the department office and inquire whether you can find an appropriate supervisor. If you want to join the Okamoto laboratory, then you also contact Okamoto by e-mail.
See the website of the Graduate School of Engineering, the University of Tokyo

https://www.rcast.u-tokyo.ac.jp/en/index.html

Application for PostDoc position

  1. Contact Okamoto by e-mail
    Contact Okamoto by an email with your CV. If there are some openings in the lab, you would receive an email for the next process.
  2. Apply to the postdoctoral fellowship programs of the Japan Society for the Promotion of Science (JSPS) Contact Okamoto by an email with your CV before preparing the application form. You can find some information on the JSPS postdoctoral fellowship for foreign researchers in the

http://www.jsps.go.jp/english/e-fellow/index.html

Members

Akimitsu Okamoto
Professor

Satoshi Yamaguchi
Associate Professor

Kunihiko Morihiro
Assistant Professor

Takafumi Furuhata
Assistant Professor

Takahiro Kosaka
DC

D.R. Phebee Angeline
DC

Shan Liu
DC

Yuki Umeda
DC

Yijing Lin
DC

Yuyuan Chen
DC

Taiki Uno
M2

Usano Toyoda
M2

Yui Nemoto
M2

Mikako Hamabe
M2

Shunto Morita
M2

Xueyang Li
M2

Xuanyu Liao
M2

Yunsong Xu
M2

Zihao Wang
M2

Ryosei Komiyama
M1

Yasuhiro Tomida
M1

Soshu Yasuda
M1●‡

Ryotaro Yamamoto
M1

Kazuki Yoshida
M1

Takahisa Niwa
B4

Manami Baba
B4

Naoki Harada
B4

Jotaro Miyamoto
B4

Yuki Ohashi
Project Researcher

Masako Takatsu
Project research personnel / Visiting Ph.D. candidate

Chie Shishido
Secretary

Department of Chemistry and Biotechnology / Department of Advanced Interdisciplinary Studies / JSPS Research Fellowship for Young Scientists / Spring-GX / MERIT-WINGS / Integrated MS/PhD Program (Department of Chemistry and Biotechnology) / JICA-Friendship Project

Current members & Alumni (in Japanese)

Class Information

講義「基礎機能化学II」(3775-105)担当:岡本 晃充 教授
講義資料:基礎機能1回目(配布用); 基礎機能2回目(配布用)

Course: Basics for Functional Chemistry II(3775-105)Professor Akimitsu OKAMOTO
Handouts: 基礎機能1回目(配布用); 基礎機能2回目(配布用)

講義「生命化学II」(3775-007)担当:岡本 晃充 教授
講義資料:生命化学II(12-01)配布用; 生命化学II(12-05)配布用; 生命化学II(12-08)配布用; 生命化学II(12-12)配布用

講義「生命化学演習」(FEN-CB3m07S1)担当:鈴木 勉 教授
講義資料:第1回_化学平衡第2回_酵素反応速度論; 第4回_核酸の構造と機能第7回_タンパク質の構造・機能

講義「初年次ゼミナール理科」(化学で生命の謎解き ~COVID-19とその周辺技術を題材にして~)担当:岡本 晃充 教授、森廣 邦彦 助教、古畑 隆史 助教
講義資料:第4回_タンパク質の機能・ウイルス感染; 第5回_核酸医薬の実用化に向けた化学戦略; 第10回 論文から先端研究を読み解こう

バーチャル先端研公開 2020
DNAオリガミ(小)折り方
DNAオリガミ(小)型紙

 

 

The Research Center for Advanced Science and Technology (RCAST), The University of Tokyo

RCAST Bldg. No.3, 6th Floor
4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan

7 minutes on foot from Higashi-Kitazawa, Odakyu Line
12 minutes on foot from Yoyogi-Uehara, Odakyu Line / Tokyo Metro Chiyoda Line
10 minutes on foot from Komaba-Todaimae, Keio Inokashira Line
10 minutes on foot from Ikenoue, Keio Inokashira Line

Phone: +81-3-5452-5200 (Office), +81-3-5452-5205 (Laboratory)
FAX: +81-3-5452-5209 / E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp

郵便物宛先

〒153-8904 東京都目黒区駒場4-6-1
東京大学 先端科学技術研究センター
生命反応化学分野 岡本研究室

宅急便宛先

〒153-8904 東京都目黒区駒場4-6-1
東京大学 先端科学技術研究センター 3号館6階
生命反応化学分野 岡本研究室

小田急線/東京メトロ千代田線・代々木上原駅より徒歩12分
小田急線・東北沢駅から徒歩7分
京王井の頭線・駒場東大前駅西口から徒歩10分
京王井の頭線・池ノ上駅から徒歩10分

電話番号: 03-5452-5200(教授室)/03-5452-5205(研究室)
FAX番号: 03-5452-5209/E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp

小田急線/東京メトロ千代田線・代々木上原駅より徒歩12分
小田急線・東北沢駅から徒歩7分
京王井の頭線・駒場東大前駅西口から徒歩10分
京王井の頭線・池ノ上駅から徒歩10分

電話番号:
03-5452-5200(教授室)/03-5452-5205(研究室)
FAX番号: 03-5452-5209
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp