東京大学　農学生命科学研究科　応用生命化学専攻

　

2024年

Yamauchi Y, Abe-Dohmae S, Iwamoto N, Sato R, Yokoyama S.(2024)
ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice..
Biochim Biophys Acta Mol Cell Biol Lipids. 1869(8):159546.
[PubMed]

Saito H, Nishimura M, Sato R, Yamauchi Y.(2024)
Quantitative Determination of Cholesterol Hydroxylase Specificities by GC-MS/MS in Living Mammalian Cells.
Bio Protocol 14(2):e4924.
[PubMed]

Maruyama T, Takahashi Y, Hiro K, Murase K, Kojima H, Okabe T, Yamauchi Y, Sato R.(2024)
Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening.
ACS Med Chem Lett. 13(1):5407.
[PubMed]

　

2023年

Takahashi Y, Inoue Y, Sato S, Okabe T, Kojima H, Kiyono H, Shimizu M, Yamauchi Y, Sato R.(2023)
Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies.
Sci Rep 19(1):e2300365.
[PubMed]

　

Kuboyama-Sasaki A, Takahashi Y, Xia C, Hiro K, Kobayashi T, Ohdan H, Shimizu M, Yamauchi Y, Kiyono H, Sato R.(2023)
Establishment of a cell culture platform for human liver organoids and its application for lipid metabolism research.
Biotechnol J 19(1):e2300365.
[PubMed]

　

Saito H, Tachiura W, Nishimura M, Shimizu M, Sato R, Yamauchi Y.(2023)
Hydroxylation site-specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR.
J Biol Chem. 299:102733.
[PubMed]

　　　

Han SI, Nakakuki M, Nakagawa Y, Wang Y, Araki M, Yamamoto Y, Tokiwa H, Takeda H, Mizunoe Y, Motomura K, Ohno H, Kainoh K, Murayama Y, Aita Y, Takeuchi Y, Osaki Y, Miyamoto T, Sekiya M, Matsuzaka T, Yahagi N, Sone H, Daitoku H, Sato R, Kawano H, Shimano H.(2023)
Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.
PNAS Nexus. doi: 10.1093/pnasnexus/pgad351.
[PubMed]

　　　

Sasaki T, Ikari N, Hashimoto S, Sato R.(2023)
Identification of α-ionone, nootkatone, and their derivatives as TGR5 agonists.
Biochem Biophys Res Commun. 653:147-152.
[PubMed]

佐藤隆一郎 (2023) 代謝制御を標的とした機能性食品成分の探索と機能解析　バイオサイエンスとインダストリー　81, 108-112.

　

佐藤隆一郎 (2023) 食の評価系（in vitroオルガノイド培養システム） 実験医学　41: 64-69.

2022年

Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R. (2022)
Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids.
J. Biol. Chem. doi: 10.1016/j.jbc.2022.102534
[PubMed] [研究成果]

Takahashi Y, Noguchi M, Inoue Y, Sato S, Shimizu M, Kojima H, Okabe T, Kiyono H, Yamauchi Y, Sato R. (2022)
Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies.
iScience doi: 10.1016/j.isci.2022.104542
[PubMed] [研究成果]

Watanabe S, Sudo Y, Makino T, Kimura S, Tomita K, Noguchi M, Sakurai H, Shimizu M, Takahashi Y, Sato R, Yamauchi Y. (2022)
Skeletal muscle releases extracellular vesicles with distinct protein and microRNA signatures that function in the muscle microenvironment.
PNAS Nexus. doi.org/10.1093/pnasnexus/pgac173
[PubMed] [研究成果]

Suzuki T, Shimizu M, Yamauchi Y, Sato R. (2022)
Nobiletin enhances plasma Interleukin‐6 and C‐X‐C motif chemokine ligand 1 levels that are increased by treadmill running.
Food Sci. Nutr. doi: 10.1002/fsn3.2844
[PubMed]

Shimizu M, Sato R. (2022)
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling.
Cells 11: 505-446.
[PubMed]

Sasaki T, Okuda M, Hong TW, Watanabe Y, Takahashi Y, Shimizu M, Yamauchi Y, Sato R.(2022)
Sesamin and Hepatic Metabolites Derived from Sesamin and Episesamin Antagonize Farnesoid X Receptor and Reduce the Expression of Gluconeogenesis-Related Genes.
J. Nutr. Sci. Vitaminol. (Tokyo) 68:55-64.
[PubMed]

Honda M, Makino T, Zhao X, Matsuto M, Sakurai H, Takahashi Y, Shimizu M, Sato R, Yamauchi Y.(2022)
Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes.
Am J Physiol Cell Physiol. 323: C1402-C1409.
[PubMed]

Miyata S, Kodaka M, Kikuchi A, Matsunaga Y, Shoji K, Kuan YC, Iwase M, Takeda K, Katsuta R, Ishigami K, Matsumoto Y, Suzuki T, Yamamoto Y, Sato R, Inoue J.(2022)
Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation.
Sci. Rep.doi: 10.1038/s41598-022-12347-6
[PubMed]

佐藤隆一郎 (2022) エルゴジェニックエイド：食品成分の可能性　日本食品安全協会会誌 17, 67-74.

　

佐藤隆一郎 (2022) フラボノイド類による代謝改善効果の新規な分子機構　日本ポリフェノール学会雑誌 11, 17-20.

2021年

Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R. (2021)
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
J. Biol. Chem. 297, 100989.
[PubMed]

Takahashi Y, Inoue Y, Kuze K, Sato S, Shimizu M, Kiyono H, Yamauchi Y, Sato R.(2021) B.B.B.論文賞
Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids.
Biosci Biotechnol Biochem.
[PubMed]

Sasaki T, Watanabe Y, Kuboyama A, Oikawa A, Shimizu M, Yamauchi Y, Sato R. (2021)
Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice.
J. Biol. Chem. 296, 100131.
[PubMed]

Suzuki T, Shimizu M, Yamauchi Y, Sato R.(2021) B.B.B.論文賞
Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats.
Biosci Biotechnol Biochem. 85, 440-446.
[PubMed]

Murata S, Sasaki T, Yamauchi Y, Shimizu M, Sato R.(2021) B.B.B.論文賞
Maslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy.
Biosci Biotechnol Biochem. 85, 311-2321.
[PubMed]

Suzuki T, Shimizu M, Yamauchi Y, Sato R.(2021)
Orange peel extract reduces the inflammoatory state of skeletal muscle after downhill running via an increase in IL-1RA.
Biosci Biotechnol Biochem. 85, 1506-1513.
[PubMed]

　　　　　

山内祥生、佐々木崇、佐藤隆一郎 (2021) ステロール代謝と骨格筋機能：医・食・薬からの統合的知見　生化学 93, 930015.

　　　　

2020年

Chikazawa M, Morikawa Y, Uramoto M, Yamauchi Y, Shimizu M, Shimizu K, Sato R. (2020)
Functional effect of nobiletin as a food-derived allosteric modulator of mouse CRFR2β in skeletal muscle
Biochem Biophys Res Commun. 529, 328-334.
[PubMed]

Sato R. (2020)
Recent advances in regulating cholesterol and bile acid metabolism.
Biosci Biotechnol Biochem. 522, 113-120.
[PubMed]

Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R. (2020)
Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
J. Biol. Chem. 295, 3918-3928.
[PubMed]

Chikazawa M, Shimizu M, Yamauchi Y, Sato R. (2020)
Bridging molecules are secreted from the skeletal muscle and potentially regulate muscle differentiation.
Biochem Biophys Res Commun. 522, 113-120.
[PubMed]

佐々木崇、佐藤隆一郎 (2020) 加齢による骨格筋機能低下のメカニズム 運動機能・認知機能改善食品の開発　23-30.

佐藤隆一郎 (2020) 摂食シグナルを受容する胆汁酸受容体TGR5 実験医学　38: 132-137.

高橋裕、佐藤慎太郎、佐藤隆一郎 (2020) iPS細胞を活用したい生理機能の高いヒトモデルの構築とその応用 実験医学　38: 224-230.

2019年

　　　　　　　

2018

　　　　　　　

Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi K, Ogawa H, Shima Y, Wang L, Sato R, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi KI,

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.

Commun Biol. 1: 18, 2018 [PubMed]

Aoki H, Hanayama M, Mori K, Sato R.

Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice.

Biosci Biotechnol Biochem. 82: 1550-1559, 2018. [PubMed]

Yamauchi Y, Rogers MA.

Sterol Metabolism and Transport in Atherosclerosis and Cancer.

Front Endocrinol. 9: 509, 2018. [PubMed]

Chikasawa M, Sato R.

Identification of a novel function of resveratrol and genistein as a regulator of β2 -adrenergic receptor expression in skeletal muscle cells and characterization of promoter elements required for promoter activation.

Mol Nutr Food Res. in press, 2018. [PubMed]

Inoue J, Miyata S, Shimizu M, Sato R.

Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins.

Biosci Biotechnol Biochem. 82: 1591-1598, 2018. [PubMed]

Kuboyama A, Sasaki T, Shimizu M, Inoue J, Sato R.

The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress.

Biosci Biotechnol Biochem. 82: 1377-1383, 2018. [PubMed]

Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R.

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice.

J. Biol. Chem. 293: 10322-10332, 2018. [PubMed]

Maruyama R, Shimizu M, Hashidume T, Inoue J, Itoh N, Sato R.

FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions.

J Nutr Sci Vitaminol (Tokyo). 64: 200-208, 2018. [PubMed]

Chikasawa M, Sato R.

Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle.

J Nutr Sci Vitaminol (Tokyo). 64: 68-74, 2018. [PubMed]

2017

Chang TY, Yamauchi Y, Hasan MT, Chang C.

Cellular cholesterol homeostasis and Alzheimer's disease.

J Lipid Res. 58: 2239-2254, 2017. [PubMed]

Yamauchi Y, Yokoyama S, Chang TY.

Methods for monitoring ABCA1-dependent sterol release.

Methods Mol Biol. 1583: 257-273, 2017. [PubMed]

Shimano H, Sato R.

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

Nature Rev Endocrinol. 13: 710-730, 2017. [PubMed]

Sasaki T, Mita M, Ikari N, Kuboyama A, Hashimoto S, Kaneko T, Ishiguro M, Shimizu M, Inoue J, Sato R.

Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.

PLoS One. 12: e0179226, 2017. [PubMed]

Inoue J, Ikeda S, Kanayama T, Sato R.

The flavonoid derivative 4'-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK.

Biosci Biotechnol Biochem. 81: 1548-1552, 2017. [PubMed]

Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Hirano S, Shimizu M, Kominami R, Sato R.

BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice.

Biosci Biotechnol Biochem. 81: 922-930, 2017. [PubMed]

Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein.

J Biol Chem. 292: 3016-3028, 2017. [PubMed]

2016

Yamauchi Y, Yokoyama S, Chang TY.

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis.

J Lipid Res. 57: 77-88, 2016. [PubMed]

Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M.

Raft-based interactions of gangliosides with a GPI-anchored receptor.

Nature Chem Biol. 12: 402-410, 2016. [PubMed]

Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K.

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.

Sci Rep. 6: 34505, 2016. [PubMed]

Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Int J Oncol. 49: 1369-1376, 2016. [PubMed]

Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K.

Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.

Glycobiology. 26: 984-998, 2016. [PubMed]

Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R.

Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.

Sci Rep. 6: 28183, 2016. [PubMed]

Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Nakai Y, Hirano S, Shimizu M, Kominami R, Sato R.

Identification of BCL11B as a regulator of adipogenesis.

Sci Rep. 6: 32750, 2016. [PubMed]

2015

Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.

Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum.

J Biol Chem. 290: 23464-77, 2015. "Selected as a Paper of the Week" [PubMed]