東京大学 農学生命科学研究科 応用生命化学専攻

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Publications

 

2022年

Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R. (2022)
Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids.
J. Biol. Chem. doi: 10.1016/j.jbc.2022.102534
[PubMed] [研究成果]

Takahashi Y, Noguchi M, Inoue Y, Sato S, Shimizu M, Kojima H, Okabe T, Kiyono H, Yamauchi Y, Sato R. (2022)
Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies.
iScience doi: 10.1016/j.isci.2022.104542
[PubMed] [研究成果]

Suzuki T, Shimizu M, Yamauchi Y, Sato R. (2022)
Nobiletin enhances plasma Interleukin‐6 and C‐X‐C motif chemokine ligand 1 levels that are increased by treadmill running.
Food Sci. Nutr. doi: 10.1002/fsn3.2844
[PubMed]

Shimizu M, Sato R. (2022)
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling.
Cells 11: 505-446.
[PubMed]

Sasaki T, Okuda M, Hong TW, Watanabe Y, Takahashi Y, Shimizu M, Yamauchi Y, Sato R.(2022)
Sesamin and Hepatic Metabolites Derived from Sesamin and Episesamin Antagonize Farnesoid X Receptor and Reduce the Expression of Gluconeogenesis-Related Genes.
J. Nutr. Sci. Vitaminol. (Tokyo) 68:55-64.
[PubMed]

Miyata S, Kodaka M, Kikuchi A, Matsunaga Y, Shoji K, Kuan YC, Iwase M, Takeda K, Katsuta R, Ishigami K, Matsumoto Y, Suzuki T, Yamamoto Y, Sato R, Inoue J.(2022)
Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation.
Sci. Rep.doi: 10.1038/s41598-022-12347-6
[PubMed]

佐藤隆一郎 (2022) エルゴジェニックエイド:食品成分の可能性 日本食品安全協会会誌 17, 67-74.

 

佐藤隆一郎 (2022) フラボノイド類による代謝改善効果の新規な分子機構 日本ポリフェノール学会雑誌 11, 17-20.

2021年

Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R. (2021)
Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
J. Biol. Chem. 297, 100989.
[PubMed]

Takahashi Y, Inoue Y, Kuze K, Sato S, Shimizu M, Kiyono H, Yamauchi Y, Sato R.(2021) B.B.B.論文賞
Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids.
Biosci Biotechnol Biochem.
[PubMed]

Sasaki T, Watanabe Y, Kuboyama A, Oikawa A, Shimizu M, Yamauchi Y, Sato R. (2021)
Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice.
J. Biol. Chem. 296, 100131.
[PubMed]

Suzuki T, Shimizu M, Yamauchi Y, Sato R.(2021) B.B.B.論文賞
Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats.
Biosci Biotechnol Biochem. 85, 440-446.
[PubMed]

Murata S, Sasaki T, Yamauchi Y, Shimizu M, Sato R.(2021) B.B.B.論文賞
Maslinic acid activates mTORC1 and human TGR5 and induces skeletal muscle hypertrophy.
Biosci Biotechnol Biochem. 85, 311-2321.
[PubMed]

Suzuki T, Shimizu M, Yamauchi Y, Sato R.(2021)
Orange peel extract reduces the inflammoatory state of skeletal muscle after downhill running via an increase in IL-1RA.
Biosci Biotechnol Biochem. 85, 1506-1513.
[PubMed]

     

山内祥生、佐々木崇、佐藤隆一郎 (2021) ステロール代謝と骨格筋機能:医・食・薬からの統合的知見 生化学 93, 930015.

    

2020年

Chikazawa M, Morikawa Y, Uramoto M, Yamauchi Y, Shimizu M, Shimizu K, Sato R. (2020)
Functional effect of nobiletin as a food-derived allosteric modulator of mouse CRFR2β in skeletal muscle
Biochem Biophys Res Commun. 529, 328-334.
[PubMed]

Sato R. (2020)
Recent advances in regulating cholesterol and bile acid metabolism.
Biosci Biotechnol Biochem. 522, 113-120.
[PubMed]

Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R. (2020)
Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
J. Biol. Chem. 295, 3918-3928.
[PubMed]

Chikazawa M, Shimizu M, Yamauchi Y, Sato R. (2020)
Bridging molecules are secreted from the skeletal muscle and potentially regulate muscle differentiation.
Biochem Biophys Res Commun. 522, 113-120.
[PubMed]


佐々木崇、佐藤隆一郎 (2020) 加齢による骨格筋機能低下のメカニズム 運動機能・認知機能改善食品の開発 23-30.

2019年

Iwase M, Watanabe K, Shimizu M, Suzuki T, Yamamoto Y, Inoue J, Sato R. (2019)
Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins.
Biosci Biotechnol Biochem. 83, 1740-1746.
[PubMed]


佐藤隆一郎 (2019) 摂食シグナル胆汁酸を感知する受容体TGR5による骨格筋機能維持機構 臨床栄養 134, 596-600.


佐藤隆一郎 (2019) オキシステロール代謝と疾患制御 医学のあゆみ 269, 1181-1186.


佐藤隆一郎 (2019) 健康寿命延伸をもたらす運動機能性食品の開発展望 ソフト・ドリンク技術資料 188, 91-103.(201-213)


佐藤隆一郎 (2019) 健康寿命延伸をもたらす運動機能を模倣する機能性食品 FOOD STYLE 21 23, 49-51.


佐々木崇・佐藤隆一郎 (2019) 骨格筋の脂質代謝メカニズム 筋肉研究最前線 23-30.


佐藤隆一郎 (2019) 健康寿命延伸をもたらす運動機能を模倣する機能性食品 FOOD STYLE 21 23, 49-51.

       

2018

       

Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi K, Ogawa H, Shima Y, Wang L, Sato R, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi KI,

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.

Commun Biol. 1: 18, 2018 [PubMed]


Aoki H, Hanayama M, Mori K, Sato R.

Grifola frondosa (Maitake) extract activates PPARδ and improves glucose intolerance in high-fat diet-induced obese mice.

Biosci Biotechnol Biochem. 82: 1550-1559, 2018. [PubMed]


Yamauchi Y, Rogers MA.

Sterol Metabolism and Transport in Atherosclerosis and Cancer.

Front Endocrinol. 9: 509, 2018. [PubMed]


Chikasawa M, Sato R.

Identification of a novel function of resveratrol and genistein as a regulator of β2 -adrenergic receptor expression in skeletal muscle cells and characterization of promoter elements required for promoter activation.

Mol Nutr Food Res. in press, 2018. [PubMed]


Inoue J, Miyata S, Shimizu M, Sato R.

Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins.

Biosci Biotechnol Biochem. 82: 1591-1598, 2018. [PubMed]


Kuboyama A, Sasaki T, Shimizu M, Inoue J, Sato R.

The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress.

Biosci Biotechnol Biochem. 82: 1377-1383, 2018. [PubMed]


Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R.

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice.

J. Biol. Chem. 293: 10322-10332, 2018. [PubMed]


Maruyama R, Shimizu M, Hashidume T, Inoue J, Itoh N, Sato R.

FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions.

J Nutr Sci Vitaminol (Tokyo). 64: 200-208, 2018. [PubMed]


Chikasawa M, Sato R.

Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle.

J Nutr Sci Vitaminol (Tokyo). 64: 68-74, 2018. [PubMed]


2017

Chang TY, Yamauchi Y, Hasan MT, Chang C.

Cellular cholesterol homeostasis and Alzheimer's disease.

J Lipid Res. 58: 2239-2254, 2017. [PubMed]


Yamauchi Y, Yokoyama S, Chang TY.

Methods for monitoring ABCA1-dependent sterol release.

Methods Mol Biol. 1583: 257-273, 2017. [PubMed]


Shimano H, Sato R.

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.

Nature Rev Endocrinol. 13: 710-730, 2017. [PubMed]


Sasaki T, Mita M, Ikari N, Kuboyama A, Hashimoto S, Kaneko T, Ishiguro M, Shimizu M, Inoue J, Sato R.

Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model.

PLoS One. 12: e0179226, 2017. [PubMed]


Inoue J, Ikeda S, Kanayama T, Sato R.

The flavonoid derivative 4'-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK.

Biosci Biotechnol Biochem. 81: 1548-1552, 2017. [PubMed]


Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Hirano S, Shimizu M, Kominami R, Sato R.

BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice.

Biosci Biotechnol Biochem. 81: 922-930, 2017. [PubMed]


Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein.

J Biol Chem. 292: 3016-3028, 2017. [PubMed]


2016

Yamauchi Y, Yokoyama S, Chang TY.

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis.

J Lipid Res. 57: 77-88, 2016. [PubMed]


Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M.

Raft-based interactions of gangliosides with a GPI-anchored receptor.

Nature Chem Biol. 12: 402-410, 2016. [PubMed]


Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K.

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.

Sci Rep. 6: 34505, 2016. [PubMed]


Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Int J Oncol. 49: 1369-1376, 2016. [PubMed]


Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K.

Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.

Glycobiology. 26: 984-998, 2016. [PubMed]


Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R.

Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.

Sci Rep. 6: 28183, 2016. [PubMed]


Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, Nakai Y, Hirano S, Shimizu M, Kominami R, Sato R.

Identification of BCL11B as a regulator of adipogenesis.

Sci Rep. 6: 32750, 2016. [PubMed]


2015

Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.

Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum.

J Biol Chem. 290: 23464-77, 2015. "Selected as a Paper of the Week" [PubMed]