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東京大学総合文化研究科
広域科学専攻生命環境科学系
加納研究室

原著論文

  • Wang, K., Ito, H., Kanoh, J., and *Ueno, M. Bqt4 affects relative movement between SPB and nucleolus in fission yeast. Biochem. Biophys. Res. Commun., 714: 149970, (2024).
  • Yamamoto, I., *Nakaoka, H., Takikawa, M., Tashiro, S., Kanoh, J., *Miyoshi, T., and *Ishikawa, F. Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal regions. Nucleic Acids Res., 49: 10465-10476, (2021).
  • Oizumi, Y., Kaji, T., Tashiro, S., Takeshita, Y., Date, Y., and *Kanoh, J. Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation. Nature Commun., 12: 611, (2021).
  • Kaji, T., Oizumi, Y., Tashiro, S., Takeshita, Y., and *Kanoh, J. Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation. bioRxiv, 2020.03.09.983726, (2020).
  • Hasegawa, Y., Yamamoto, M., Miyamori, J., and *Kanoh, J. Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins. Sci. Rep., 9: 9946, (2019).
  • Inoue, H., Horiguchi, M., Ono, K., and *Kanoh, J. Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation. Nucleic Acids Res., 47: 6871-6884, (2019).
  • Oizumi, Y., Koga, A., and *Kanoh, J. Alpha satellite DNA repeat OwlAlp1 forms centromeres in Azara's owl monkey. Genes Cells., 24: 511-517, (2019).
  • Hu, C., Inoue, H., Sun, W., Takeshita, Y., Huang, Y., Xu, Y., *Kanoh, J., and *Chen, Y. Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast. Nucleic Acids Res., 47: 1573-1584, (2019). (* Co-corresponding authors)
  • Hu, C., Inoue, H., Sun, W., Takeshita, Y., Huang, Y., Xu, Y., *Kanoh, J., and *Chen, Y. The inner nuclear membrane protein Bqt4 in fission yeast contains a DNA-binding domain essential for telomere association with the nuclear envelope. Structure, 27: 335-343, (2019). (* Co-corresponding authors)
  • Xue, J., Chen, H., Wu, J., Takeuchi, M., Inoue, H., Liu, Y., *Chen, Y., *Kanoh, J., and *Lei, M. Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27: 1503-1520, (2017). (* Co-corresponding authors)
  • Tashiro, S., Nishihara, Y., Kugou, K., Ohta, K., and *Kanoh, J. Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis. Nucleic Acids Res., 45: 10333-10349, (2017). Selected as a Breakthrough Article.
  • Inoue, H., Sugimoto, S., Takeshita, Y., Takeuchi, M., Hatanaka, M., Nagao, K., Hayashi, T., Kokubu, A., Yanagida, M., and *Kanoh, J. CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe. Genes Cells, 1: 59-70, (2017).
  • Tashiro, S., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H., and *Kanoh, J. Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. Nature Commun., 7: 10393, (2016).
  • Deng, W., Wu, J., Wang, F., Kanoh, J., Dehe, PM., Inoue, H., Chen, J., and Lei, M. Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2. Cell Research, 25: 881-884, (2015).
  • Tarumoto, Y., Kanoh, J., and Ishikawa, F. Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast. J. Biol. Chem, 288: 19260-19268, (2013).
  • *Kanoh, J. Release of chromosomes from the nuclear envelope: a universal mechanism for eukaryotic mitosis? Nucleus, 4: 100-104, (2013).
  • Tashiro, S., Asano, T., Kanoh, J., and Ishikawa, F. Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells, 18: 327-339, (2013).
  • Fujita, I., Tanaka, M., and *Kanoh, J. Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. PLoS ONE, 7: e49151, (2012).
  • Fujita, I., Nishihara, Y., Tanaka, M., Tsujii, H., Chikashige, Y., Watanabe, Y., Saito, M., Ishikawa, F., Hiraoka, Y., and *Kanoh, J. Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr. Biol., 22: 1932-1937, (2012).
  • Chen, Y., Rai, R., Zhou, Z-R., Kanoh, J., Ribeyre, C., Yang, Y., Zheng, H., Damay, P., Wang, F., Tsujii, H., Hiraoka, Y., Shore, D., Hu, H-Y., Chang, S. and Lei, M. A conserved motif within RAP1 plays diversified roles in telomere protection and regulation in different organisms. Nature Struct. Mol. Biol., 18: 213-221, (2011).
  • Mikawa, T., Kanoh, J. and Ishikawa, F. Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. Genes Cells, 15: 229-242, (2010).
  • Miyoshi, T., Kanoh, J. and Ishikawa, F. Fission yeast Ku protein is required for recovery from DNA replication stress. Genes Cells, 14: 1091-1103, (2009).
  • Miyoshi, T., Kanoh, J., Saito, M. and Ishikawa, F. Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science, 320: 1341-1344, (2008).
  • Hayashi, T., Hatanaka, M., Nagao, K., Nakaseko, Y., Kanoh, J., Kokubu, A., Ebe, M. and Yanagida, M. Rapamycin-sensitivity of the S. pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells, 12: 1357-1370, (2007).
  • Shikata, M., Ishikawa, F. and *Kanoh, J. Tel2 is required for the activation of Mrc1-mediated DNA replication checkpoint. J. Biol. Chem., 282: 5346-5355, (2007). (* Corresponding author)
  • *Kanoh, J., Sadaie, M. Urano T. and Ishikawa, F. Telomere-binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. Curr. Biol., 15: 1808-1819, (2005). (* Corresponding author)
  • Kanoh, J., Francesconi, S., Collura, A., Schramke, V., Ishikawa, F., Baldacci, G. and Geli, V. The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J. Mol. Biol., 326: 1081-1094, (2003).
  • Miyoshi, T., Sadaie, M., Kanoh, J. and Ishikawa, F. Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J. Biol. Chem., 278: 1924-1931, (2003).
  • Kanoh, J. and Ishikawa, F. spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol., 11: 1624-1630, (2001).
  • Lopez-Girona, A.*, Kanoh, J.* and Russell, P. Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast. Curr. Biol., 11: 50-54, (2001).(* equally contributed)
  • Kanoh, J. and Russell, P. Slm9, a novel nuclear protein involved in mitotic control in fission yeast. Genetics, 155: 623-631, (2000).
  • Kanoh, J. and Russell, P. The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol. Biol. Cell, 9: 3321-3334, (1998).
  • Kanoh, J., Watanabe, Y., Ohsugi, M., Iino, Y. and Yamamoto, M. Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells, 1: 391-408, (1996).
  • Kanoh, J., Sugimoto, A. and Yamamoto, M. Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway. Mol. Biol. Cell, 6: 1185-1195, (1995).

英文総説、著書

  • *Kanoh, J. Subtelomeres: hotspots of genome variation. Genes & Genet. Syst., 98: 155-160, (2023).
  • *Kanoh, J. Roles of specialized chromatin and DNA structures at subtelomeres in Schizosaccharomyces pombeBiomolecules, 13: 810, (2023).
  • *Kanoh, J. Unexpected roles of a shugoshin protein at subtelomeres. Genes & Genet. Syst., 92: 127-133, (2017).
  • *Kanoh, J. Telomeres and subtelomeres: new insights into the chromatin structures and functions of chromosome ends. Genes & Genet. Syst., 92: 105, (2017).
  • *Kanoh, J. and Yanagida, M. Structure of TOR complexes in fission yeast. Enzymes, 27: 271-284, (2010).
  • *Kanoh, J. and Yanagida, M. Tel2: A common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response? Genes Cells, 12: 1301-1304, (2007) .
  • *Kanoh, J. Telomere-binding proteins in fission yeast. Encyclopedia of Mol. Cell Biol. & Mol. Med., 14: 229-243, (2005).
  • *Kanoh, J. and Ishikawa, F. Composition and conservation of the telomeric complex. Cell. Mol. Life Sci., 60: 2295-2302, (2003).

邦文総説、著書

  • 加納純子 (2022) 遺伝学の百科事典 継承と多様性の源・日本遺伝学会編(丸善出版)p94-95「セントロメアとテロメア」石井浩二郎博士との共同執筆
  • 加納純子 (2021) エッセンシャル遺伝学・ゲノム科学(原著第7版)中村千春・岡田清孝監訳「13章 細胞周期とがんの分子遺伝学」翻訳
  • 加納純子 (2020) 「染色体末端サブテロメアによる遺伝子発現制御」細胞 THE CELL・vol. 52: 338-341.
  • 加納純子 (2018) 「どうすれば寿命を延ばせるの?」どうすれば心臓は動き続けるの?~生命をささえるタンパク質のなぞにせまる~, 94-97.
  • 加納純子 (2017) 「シュゴシンタンパク質が染色体末端で果たす意外な機能」生化学・vol. 89: 73-76.
  • 加納純子 (2016) 「サブテロメアはテロメアのサブじゃない」BioResource Now! 12 (6)
  • 加納純子 (2015) 第8章ゲノムを支えるインターメアの機能(2)ーテロメア機能とサブテロメアー「ゲノムを司るインターメア」Dojin Biosciene 23, 化学同人
  • 加納純子 (2013) 第5章テロメア「染色体と細胞核のダイナミクス」Dojin Biosciene 11, 化学同人
  • 加納純子 他(多数の著者の一人として) (2013) 「生物学辞典第5版」岩波書店
  • 加納純子 (2010) 「Tel2蛋白質によるPIKKファミリー蛋白質の制御機構」共立出版・細胞周期フロンティア: 119-124.
  • 加納純子他(多数の著者の一人として) (2010) 「生物学辞典」東京化学同人
  • 加納純子 (2010) 「PIKKファミリータンパク質に結合するTel2」生化学・vol. 82: 57-60.
  • 加納純子 (2009) 「テロメア特異的なクロマチン構造によるテロメアDNA維持機構」共立出版・蛋白質核酸酵素増刊・染色体サイクル・vol. 54: 514-520.
  • 加納純子、石川冬木 (2003)「テロメアの構造と機能」Springer Reviews・クロマチンと遺伝子機能制御 35-44.
  • 加納純子、石川冬木 (2002)「テロメア結合タンパク質によるテロメア制御」羊土社・実験医学増刊・ゲノム機能を担う核・染色体のダイナミクス・vol. 20: 1544-1549.
  • 加納純子 (2002) 学会見聞記「第2回 国際分裂酵母会議」共立出版・蛋白質核酸酵素・vol. 47: 1243-1245.
  • 加納純子、石川冬木 (2001)「ATMのチェックポイントとテロメア維持における役割」共立出版・蛋白質核酸酵素増刊・DNA修復ネットワークとその破綻の分子病態・vol. 46: 1194-1200.
  • 加納純子 (2001)「究極のモデル生物-分裂酵母-」日本生化学会・バイオサイエンスの新世紀 第6巻 細胞の誕生と死・86-99.

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