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東京大学農学部　生命化学・工学専修　／　東京大学大学院　農学生命科学研究科　応用生命化学専攻

食の健康科学（ニップン）寄付講座

〒113‐8657 東京都文京区弥生1-1-1　フードサイエンス棟　501-2

研究業績　RESEARCH

Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA
Taira S, Ikeda A, Sugiura Y, Shikano H, Kobayashi S, Terauchi T, Yokoyama J
PLoS One.,(2 Aug 2022);17(8):e0271697.
【Pubmed】



Optimization of the use of Py-Tag for next derivatization reagents in imaging mass spectrometry
Hitomi Shikano, Akari Ikeda, Yuko Maejima, Shoko Kobayashi, Tsutomu Terauchi, Jun Yokoyama, Kenju Shimomura, Shu Taira
J Biosci Bioeng,(1 July 2022);S1389-1723(22)00160-8.
【Pubmed】



Administration of mucuna beans(Mucuna pruriences(L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice.
Konishi F, Furusho T, Soeda Y, Yamauchi J, Kobayashi S, Ito M, Araki T, Kogure S, Takashima A, and Takekoshi S.
Sci Rep, (19 January 2022);12(1): 996
【Pubmed】



Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity.
Takashima Y, Ishikawa K, Miyawaki R, Ogawa M, Isii T, Misaka M, and Kobayashi S.
J Agric Food Chem,(25 August 2021) ; 69(33) : 9585-9596
【Pubmed】




Localization analysis of essential oils in perilla herb (Perilla frutescens var. crispa) using derivatized mass spectrometry imaging.
Taira S, Kiriake-Yoshinaga A, Shikano H, Ikeda R, Kobayashi S, and Yoshinaga K.
Food Science & Nutrition, (30 March 2021) ; 00 : 1-6
【Wiley Online Library】



Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway.
Yamamoto S, Kayama T, Noguchi-Shinohara M, Hamaguchi T, Yamada M, Abe K, and Kobayashi S.
NPJ Sci Food 5, (29 January 2021); 1
【PubMed】



Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression.
Noguchi-Shinohara M, Ono K, Hamaguchi T, Nagai T, Kobayashi S, Komatsu J, Samuraki-Yokohama M, Iwasa K, Yokoyama K, Nakamura H, and Yamada M.
Sci Rep. (29 October 2020) ; 10 : 18627.
【PubMed】



Effects of Kudoa septempunctata Infections in a Human Intestinal Epithelial Model (Caco-2): A DNA Microarray Study.
Yamamoto S, Kawano F, Yokoyama H, and Kobayashi S.
Biosci Biotechnol Biochem. (6 January 2020) ;1-9
【PubMed】



The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann-Pick C1-Like 1.
Kobayashi S.
Int J Mol Sci. (6 October 2019) ; 20(19). pii: E4939.
【PubMed】



Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion.
Hase T, Shishido S, Yamamoto S, Yamashita R, Nukima H, Taira S, Toyoda T, Abe K, Hamaguchi T, Ono K, Noguchi-Shinohara M, Yamada M, and Kobayashi S.
Sci Rep. (18 June 2019) ; 9(1) : 8711.
【PubMed】



Intestinal Anti-Inflammatory Activity of Perillaldehyde.
Uemura T, Yashiro T, Oda R, Shioya N, Nakajima T, Hachisu M, Kobayashi S, Nishiyama C, and Arimura G,
J.Agric.Food Chem. (13 March 2018) ; 66(13) : 3443-3448
【PubMed】



Effect of luteolin on the expression of intestinal cholesterol transporters.
Ogawa M,Yamanashi Y, Takada T, Abe K, and Kobayashi S,
J Funct Foods. (September 2017) ; 36 : 274-279
【ScienceDirect】



Eggshell membrane powder ameliorates intestinal inflammation by faciliating the restitution of epithelial injury and alleviating microbial dybiosis.
Jia H, Hanate M, Aw W, Itoh H, Saito K, Kobayashi S, Hachimura S, Fukuda S, Tomita M, Hasebe Y, and Kato H
Sci.Rep.(8 March 2017) ; 7 : 43993
【PubMed】



コレステロールの腸管吸収機構とその制御
小林 彰子
化学と生物. (2016) ; 54 : 379-381
【J-STAGE】



In Vitro Inactivation of Kudoa septempunctata Spores Infecting the Muscle of Olive Flounder Paralichthys olivaceus.
Yokoyama H, Funaguma N, and Kobayashi S.
Foodborne Pathog Dis. (13 January 2016) ; 13(1) : 21-27
【PubMed】



Cholesterol-lowering Effect of Calcium Alginate in Rats.
Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa H, Miyajima C, Kasahara F, and Ogihara T
Biol Pharm Bull. (2015) 39(1):62-67
【PubMed】



Pharmacokinetics, safety and tolerability of rosmarinic acid in healthy individuals.
Noguchi-Shinohara M, Ono K, Hamaguchi T, Iwasa T, Nagai T, Kobayashi S, Nakamura H, Yamada M.
PLOS One. (15 May 2015) ; 10(5) : e0126422
【PubMed】


Inhibitory effect of oligomeric polyphenols from peanut-skin on sugar digestion enzymes and glucose transport.
Tamura T, Ozawa M, Kobayashi S, Watanabe H, Arai S, and Mura K.
Food Science Technology Research. (2015) ; 21 : 111-115
【CiNii】



Anti-allergenic Activity of Polymethoxyflavones from Kaempferia parviflora.
Kobayashi S, Kato T, Azuma T, Kikuzaki H, Abe K.
Journal of Functional Foods. (March 2015) ; 13 : 100-107
【Sience Direct】



Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter niemann-pick c1-like 1 in caco-2 cells and rats. 
Nekohashi M, Ogawa M, Ogihara T, Nakazawa K, Kato H, Misaka T,
Abe K, and Kobayashi S
PLOS One. (May 23 2014) ; 9(5) : e97901
【PubMed】



Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.
Kobayashi S, Shinohara M, Nagai T, and Konishi Y.
Biosci Biotechnol Biochem. (2013) 77 (11) 2210-2217
【PubMed】



Alginate enhances excretion and reduces absorption of strontium and cesium in rats.
Idota Y, Harada H, Tomono T, Morimoto K, Kobayashi S,Kakinuma C, Miyajima C, Kasahara F, and Ogihara T.
Biol. Pharm. Bull. (23 November 2013) ; 36(3) : 485-491
【PubMed】



Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat.
Kobayashi S, Katsuyama S, Wagatsuma T, Okada S, and Tanabe S.
Biosci Biotechnol Biochem.(23 June 2012) ; 76 : 1182-1188
【PubMed】



Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes.
Kobayashi S, Nagai T, Konishi Y, Tanabe S, Morimoto K and Ogihara T
J Pharm Pharmacol. (10 November 2011) ; 64(1) : 52-60
【PubMed】