We are studying on chemistry and life science of
nucleic acid methylation/demethylation using new chemical probes
intracellular RNA behavior using special chemical probes
chromatins consisting of chemically synthesized DNA and histones
single-cell functions through trapping and release of special cells
chemical protection from protein aggregation
aggregation of functional oligonucleotides in a cell
nucleic acid delivery through chemical functionalization
proto-nucleic acids built under prebiotic environments
How are our bodies created from atoms and molecules? We systematically investigate how the atoms and building blocks of biopolymers (nucleic acids and proteins) participate in biological phenomena, introducing synthetic chemistry-based ideas into biological and genetic studies. Research in our group is concerned with diverse aspects of the design and function of biopolymers on an atomic scale. The focus is on the design, synthesis and physical properties of new, man-made biopolymers with various special functions. Also included is the design of unprecedented organic chemical systems for recognizing, transforming and visualizing a single component or atom in biopolymers of interest. These researches are the fundamental studies reflecting the essence of life science on an atomic scale and the material-developing studies to get useful functional materials for the latest studies on life sciences and medical technologies. The lab employs a multidisciplinary approach involving organic synthesis, photophysical chemistry, state-of-the-art spectroscopy, and biological assays to address new approaches to the interface between synthetic chemistry and life science. Current projects include:
- Synthesis of ‘superbiopolymers’ containing functional nucleotides and amino acids for elucidation of gene expression function.
- Construction of new chemical platforms for collecting specific cells and analyzing cell-cell interactions at the single cell level.
- Drug design, cell introduction, and functional analysis based on new chemical ideas.
- Chemical exploration of ‘proto-nucleic acids’ under prebiotic conditions.
Collection of Works
- Nucleic acid medicinehttps://doi.org/10.1021/jacs.0c10732
- Chemical synthesis of proteinshttps://doi.org/10.1039/D1SC00731A
- Catch-and-release of cellshttps://doi.org/10.1038/s41598-017-14737-7
- Peptide ligation activatorshttps://doi.org/10.1039/C9SC00646J
- Anchored cell membrane sheetshttps://doi.org/10.1021/acsabm.0c00583
- Sensing of a ‘genome lifetime’ controllerhttps://doi.org/10.1002/cbic.201900555
- Origin of ribosehttps://doi.org/10.1039/C7OB02051A
- Metallic sensing of DNA epigeneticshttps://doi.org/10.1021/jacs.6b06428
- Nucleic acid medicine
- Chemical synthesis of proteins
- Catch-and-release of cells
- Peptide ligation activators
- Anchored cell membrane sheets
- Sensing of a ‘genome lifetime’ controller
- Origin of ribose
- Metallic sensing of DNA epigenetics
Research Category List
|Bioorganic Chemistry||Organic Synthesis||Nucleic Acid Chemistry||Chemical Protein Engineering||Cell Immobilization|
|In-Cell Organic Chemistry||Live Cell Imaging||Epigenetics||Cell interaction||Raman Spectroscopy|
|Origin of Life||Photodynamic Therapy||Dye design|
Nucleic Acid Chemistry
Chemical Protein Engineering
In-Cell Organic Chemistry
Live Cell Imaging
Origin of Life
How to join us
Department of Chemistry and Biotechnology (MS/PhD integrated program)
To enroll in the Graduate School of Engineering as a graduate student, you are required to successfully pass an entrance examination.
See the website of the Department of Chemistry and Biotechnology.
Okamoto laboratory strongly encourages you to take the exam of the MS/PhD integrated program. First of all, please contact Okamoto after checking Okamoto’s papers.
Department of Advanced Interdisciplinary Studies (PhD course, no course for master degree)
The course provides mid-career persons with the opportunity to carry out doctoral studies in the university environment. Before requesting application forms, you are advised to contact the department office and inquire whether you can find an appropriate supervisor. If you want to join the Okamoto laboratory, then you also contact Okamoto by e-mail.
See the website of the Graduate School of Engineering, the University of Tokyo
Application for PostDoc position
- Contact Okamoto by e-mail
Contact Okamoto by an email with your CV. If there are some openings in the lab, you would receive an email for the next process.
- Apply to the postdoctoral fellowship programs of the Japan Society for the Promotion of Science (JSPS) Contact Okamoto by an email with your CV before preparing the application form. You can find some information on the JSPS postdoctoral fellowship for foreign researchers in the
D.R. Phebee Angeline
Technical Staff ●
Technical Staff ●
●RCAST / ●Department of Chemistry and Biotechnology / ●Department of Advanced Interdisciplinary Studies / JSPS Research Fellowship for Young Scientists / ¶WINGS-LST/GPLLI / ‡Integrated MS/PhD Program (Department of Chemistry and Biotechnology) / ◆JICA－Friendship Project
The Research Center for Advanced Science and Technology (RCAST), The University of Tokyo
RCAST Bldg. No.3, 6th Floor
4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
7 minutes on foot from Higashi-Kitazawa, Odakyu Line
12 minutes on foot from Yoyogi-Uehara, Odakyu Line / Tokyo Metro Chiyoda Line
10 minutes on foot from Komaba-Todaimae, Keio Inokashira Line
10 minutes on foot from Ikenoue, Keio Inokashira Line
Phone: +81-3-5452-5200 (Office), +81-3-5452-5205 (Laboratory)
FAX: +81-3-5452-5209 / E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp
東京大学 先端科学技術研究センター 3号館6階
FAX番号: 03-5452-5209／E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp