研究業績

研究業績


2019

原著論文

Yagi,T.,Toyoshima,Y.,Tokita,R.,Taguchi,Y.,Okamoto,Y,Takahashi,SI,Kato,H.and Minami,S.Low-protain diet enhances adiponectin secretion in rats.Biosci.Biotechnol.Biochem.83,1774-1781(2019)

Igarashi,M.,Nogawa,S.,Kawafune,K.,Hachiya,T.,Takashima,S.,jia,H.,Saito,K and Kato,H. Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese population.Gene Nutr.14,21(2019)

Jia,H.,Nogawa,S.,Kawafune,K.,Hachiya,T.,Takahashi,S.,Igarashi,M.,Saito,k.and Kato H. GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population.BMC Genet.,20,61(2019)


著書・総説

     

加藤久典、髙橋祥子 マルチオミクスとインターネットコホートによる食と栄養へのアプローチ、実験医学 37 536-541(2019)
  
加藤久典、加藤将夫(編著)「核酸の分子栄養学」エヌ・ティー・エス(2019)


2018

原著論文

Miyoshi,M.,Sato,M.,Saito,K.,Otani,L.,Shirahige,k.,Miura,F.,Ito,T.,jia,H.and Kato,H.Meternal protein restriction alters the renal ptgerl DNA methylation state in SHRSP offspring.Nutrients,, 10,1436(2018)

Hamano, M., Haraguchi, Y., Sayano, T., Zyano, C., Arimoto, Y., Kawano, Y., Moriyasu, K., Udono, M., Katakura, Y., Ogawa, T., Kato, H. and Furuya, S. Enhanced vulnerability to oxidative stress and induction of inflammatory gene
exprssion in 3-phosphoglycerate dehydrogenase-deficient fibroblasts. FEBS Open Bio, 8,914-922(2018)


2017

原著論文

Horiucti ,M., Takeda, T., Takanashi, H., Ozaki-Masuzawa, Y., Taguchi, Y.,Toypshima, Y., Otani, L., Kato, H., Sone-Yonezawa, M.,Hakuno, F., Takahashi, S.-I. and Takenaka, A. Branched-chain amino acid supplementation restores
reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats. Nutr.Metab. 14, 59 (2017)

Taguchi, Y., Tokita, R., Kato, H., Takahashi, S.-I., and Minami, S. Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling. Biochem. Biophys. Res. Commun. 490,800-805 (2017)

Lyu, W., Jia, H., Deng, C., Saito, K., Yamada, S. and Kato, H. Zeolite-containing mixture supplementation ameliorated dextran sodium sulphate-induced colitis in mice by suppressing the inflammatory bowel disease pathway and improving apoptosis in colon mucosa. Nutrients 9, 467 (2017)

Jia, H., Hanate, M., Aw, W., Itoh, H., Saito, K., Kobayashi, S., Hachimura, S., Fukuda, S., Tomita, M., Hasebe, Y. and Kato. H. Eggshell membrane powder ameliorates intestinal inflammation by faciliating the restitution of epithelial injury and alleviating microbial dybiosis. Sci. Rep. 7, 43993 (2017)

Sato, Y., Uchida, E., Aoki, H., Hanamura, T., Nagamine, K., Kato, H., Koizumi, T. and Ishigami, A. Acerola (Malpighia emarginata DC.) juice intake suppresses the UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice PLoS One, e0170438 (2017)

Takahashi, S., Jia, H., Saito, K. and Kato, H. Comparative integrated omics approach sterically understanding hepatic metabolic dynamics in mouse model. J. Integr. OMICS 7,200 (2017)

Nakamura, K., Morishita, S., Ono, T,. Murakoshi, M., Sugiyama, K., Kato, H., Ikeda, I. and Nishino, H. Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats. Biochem. Cell Biol. 95,142-147 (2017)

2016

原著論文


Aoyama, S., Jia, H., Nakazawa, K., Yamamura, J., Saito, K. and Kato, H. Dietary genistein prevents denervation-induced muscle atrophy in rodents via effects on estrogen receptor-alpha J. Nutr.146, 1146-1154 (2016)

Otani, L,. Mori, T., Koyama, A,. Takahashi, S.-I., and Kato, H. Supplemental arginine above the requirement during suckling causes obesity and insulin resistance in rats. Nutr. Res. 36, 575-585 (2016)

Sayano, T., Kawano, Y., Kusada, W., Arimoto, Y., Esaki, K., Hamano, M., Udono, M., Katakura, Y., Ogawa, T., Kato, H., Hirabayashi, Y. and Furuya, S. Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via deoxysphinganine in normal fibroblasts. FEBS Open Bio 6, 303-316 (2016)

Morishita, S., Kawaguchi H., Ono, T., Miura, N., Murakoshi, M., Sugiyama, K., Kato, H., Tanimoto, A. and Nishino, H. Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. Biosci. Biotechnol. Biotechem.80, 295-393(2016)

2015

原著論文

Yoshimura, R, Takai, M., Namaki, H., Minami, K., Imamura, W., Kato, H., Kamei, Y. and Kanamoto R. Down regulation of asparagine synthetase and 3-phosphoglycerate dehydrogenase, and the up-regulation of serine dehydratase in rat liver from intake of excess amount of leucine are not related to leucine-caused amino acid imbalance. J. Nutr. Sci. Vitaminol. 61, 441-448 (2015)

Morishita, S., Tomita, K., Ono, T., Murakoshi, M., Saito, K., Sugiyama, K., Nishino, H. and Kato, H. Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. Biochem. Cell Biol.93, 566-573 (2015)

Ozaki, Y., Saito, K., Nakazawa, K,. Konishi, M., Itoh, N., Hakuno, H., Takahashi, S.-I., Kato, H. and Takenaka, A. Rapid increase of fibroblast growth factor 21 under protein malnutrition and its impact on growth and lipid metabolism. Brit. J. Nutr.114, 1410-1418 (2015)

Li, J., Inoue, J., Choi, J.-M., Nakamura, S., Yan, Z., Fushinobu, S., Kamada, H., Kato, H., Hashidume, T., Shimizu, M. and Sato, R. Identification of the flavonoid luteolin as a repressor of the transcription factor hepatocyte nuclear factor 4a . J. Biol. Chem.290, 24021-24031 (2015)

著書・総説

Aw, W., Jia, H., Takahashi, S., Fukuda, S. and Kato, H. Chapter 3: The comprehensive understanding of anti-diabetic and anti-obesity effects of coffee intake via nutrigenomics. In: Caffeic acid: Biological properties, structure and health effects. Vaughn, L (ed) Nova Science Publishers, pp. pp. 47-62 (2015)

2014

原著論文

Jia, H., Aw, W., Saito, K., Hanate, M,m Hasebe, Y. and Kato, H. Eggshell membrane ameliorates hepatic fibrogenesis in human C3A cells and rats through changes in PPARγ-Endothelin 1 signaling. Sci. Rep.,4,7473(2014)

Jia,H., Aw, W., Hanate, M., Takahashi, S., Saito, K., Tanaka, H., Tomita, M. and Kato, H. Multi-faceted integrated omics analysis revealed Parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice. J. Funct. Food 11,438-448(2014)

Chang, W.-C., Jia, H., Aw, W. Saito, K., Hasegawa, S. and Kato, H. Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of Type 2 diabetes and NAFLD in high fructose-fed rats. Brit. J. Nutr.112, 719-717(2014)

Nekohashi, M., Ogawa, M., Ogihara, T., Nakazawa, K., Kato, H., Misaka, T., Abe, K. and Kobayashi, S. Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter Niemann–Pick C1-like 1 in Caco-2 cells and rats. PLoS One. 9, e97901 (2014)

Fukushima, E., Monoi, N., Mikoshiba, S., Hirayama, Y., Serizawa, T., Adachi, K., Koide, M., Ohdera, M., Murakoshi, M. and Kato, H. Protective effects of acetaminophen on ibuprofen-induced gastric mucosal damage in rats with associated suppression of matrix metalloproteinase. J. Pharmacol. Exp. Ther.349,165-173 (2014)

Takahashi, S., Saito, K., Jia, H. and Kato, H. An integrated multi-omics study revealed metabolic alterations underlying the effects of coffee consumption. PLOS ONE, 9, e91134 (2014)

Toyoshima, Y., Tokita, R., Taguchi, Y., Akiyama-Akanishi, N., Takenaka, A., Kato, H., Chida, K., Hakuno, F., Minami, S. and Takahashi, S.-I. Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats. Endocr. J. 61,499-512 (2014)

Jia, H., Aw, W., Egashira, K., Takahashi, S., Aoyama, S., Saito, K., Kishimoto, Y. and Kato, H. Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice. Genes Nutr.9,389 (2014)

Jia, H., Aw, W., Saito, K., Hanate, M,m Hasebe, Y. and Kato, H. Eggshell membrane ameliorates hepatic fibrogenesis in human C3A cells and rats through changes in PPARγ-Endothelin 1 signaling. Sci. Rep., 4, 7473 (2014)

著書・総説

Jia, H., Tamura, N., Aw, W., Doi, M. and Kato, H. Identification of branched amino acids; Underlying molecular pathways using transcriptomics analysis: Application to cirrhosis. In: Branched chain amino acids in clinical nutrition vol. 2. Rajendram, R., Preedy, V.R. and Patel, V.B. (eds) Humana Press, pp141-157 (2014)

小田裕昭、加藤久典、関泰一郎(編著)「健康栄養学-健康科学としての栄養生理化学- 第2版」共立出版(2014)

賈慧娟、花手愛夏、加藤久典、長谷部由紀夫 卵殻膜摂取による潰瘍性大腸炎の抑制効果Food Style 21, 18, 80-82 (2014)

加藤久典ニュートリゲノミクス 食品と栄養における網羅的解析、化学と工業、67, 122-124 (2014)

Srinivasan,V., Mohamed, M., and Kato, H. Melatonin: its microbicidal propertiesand clinical applications. In: Melatonin and melatonergic drugs in clinical practice. Srinivasan, V., Brzezinski, A., Oter, S. and Shillcutt, S.D. (eds) Springer, 57-69, (2014)

加藤久典 ニュートリゲノミクスの広がりと統合ニュートリオミクス、New Diet Therapy, 29(4), 15-22 (2014)

加藤久典 第5章 タンパク質の構造と機能、第6章 酵素 「新スタンダード栄養・食物シリーズ 生化学」(大塚譲他編)東京化学同人 pp. 29-46 (2014)

加藤久典第2章6 アミノ酸摂取と遺伝子発現 「アミノ酸科学の最前線-基礎研究を活かした応用戦略―」(鳥居邦夫、門脇基二監修)シーエムシー出版 pp.94-99 (2014)

加藤久典、藤原葉子(編) 「栄養科学イラストレイテッド:分子栄養学~遺伝子の基礎からわかる」羊土社 (2014)

加藤久典 アミノ酸の機能や安全性の研究におけるオミクス 生化学, 86, 318-323 (2014)

2013

原著論文

Jia, H., Takahashi,S., Saito, K. and Kato, H. DNA microarray analysis identified molecular pathways mediating the effect of the supplementation of branched amino acids on CCl4-induced cirrhosis in rats. Mol. Nutr. Food Res. 57, 291-306 (2013)

Imamura, W., Yoshimura, R., Takai, M., Yamamura, J., Kanamoto, R. and Kato, H. Adverse effects of excessive leucine intake depend on dietary protein intake: A transcriptomic analysis to identify useful biomarkers. J. Nutr.Sci. Vitaminol. 59,45-55(2013)

Ono, T., Fujisaki, C., Ishihara, Y, Ikoma, K., Morishita, S., Murakoshi, M., Sugiyama, K., Kato, H., Miyashita, K., Yoshida, K. and Nishino, H. Potent lipolytic activity of lactoferrin in mature adipocytes. Biosci. Biotechnol. Biochem.77, 566-571 (2013)

Jia, H., Saito, K., Aw, W., Takahashi, S., Hanate, M, and Kato, H. Transcriptional profiling in rats and an ex vivo analysis implicate novel beneficial function of egg shell membrane in liver fibrosis. J. Funct. Foods 5. 1611-1619 (2013)

Takahashi, S., Egashira, K., Jia, H., Saito, K., Abe, K. and Kato, H. Coffee intake down-regulates the hepatic gene expression of peroxisome proliferator-activated receptor gamma in C57BL/6J mice fed a high-fat diet. J. Funct. Foods, 6, 157-167 (2014)

著書・総説

加藤久典、青山晋也 高齢者の筋機能維持に向けた大豆成分の有効利用の基礎研究 大豆タンパク質研究、15, 85-89 (2013)

斉藤憲司、高橋祥子、加藤久典 第3章 ニュートリゲノミクスを加速するツールの開発 「ニュートリゲノミクスを基盤としたバイオマーカーの開発-未病診断とテーラーメード食品開発に向けて-」シーエムシー出版、PP39-44(2013)

大谷りら、村上哲男、加藤久典 タンパク質栄養に起因する生活習慣病発症機序 胎児期から新生児期に刻まれる栄養の記憶、化学と生物、51,785-788(2013)

2012

原著論文

Morishita, S., Ono, T., Fujisaki, C., Ishihara, Y., Murakoshi, M., Kato, H., Hosokawa, M., Miyashita, K., Sugiyama, K. and Nishino, H. Bovine lactoferrin reduces visceral fat and liver triglycerides in ICR mice. J. Oleo Sci. 62:97-103 (2012)

Jia, H., Takahashi, S., Saito, K. and Kato, H. DNA microarray analysis identified molecular pathways mediating the effect of the supplementation of branched amino acids on CCl4-induced cirrhosis in rats. Mol. Nutr. Food Res. 57, 291-306 (2013)

Wu, T., ZhuGe, F., Sun, L., Ni, Y., Fu, O., Gao, G., Chen, J., Kato, H. and Fu, Z. Enhanced effect of daytime restricted feeding on the circadian rhythm of streptozotocin-induced type 2 diabetic rats. Am. J. Physiol. Endocrinol. Metab, 302, E1027-1035 (2012)

Ha, B.G., Nagaoka, M., Yonezawa, T., Tanabe, R., Woo, J.T., Kato, H., Chung, U.I. and Yagasaki, K. Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo. J. Nutr. Biochem 23, 501-509 (2012)

Otani, L., Sugimoto, N., Kaji, M., Murai, M., Chang, S.-J., Kato, H. and Murakami, T. Role of the renin-angiotensin-aldosterone system in the enhancement of salt sensitivity caused by prenatal protein restriction in stroke-prone spontaneously hypertensive rats. J. Nutr. Biochem. 23, 892-899 (2012)

著書・総説

加藤久典 第1章 アミノ酸の機能 「機能性アミノ酸・ペプチドの技術と市場」、シーエムシー出版、pp3-11 (2012)

勝呂栞、山岸淑恵、大谷りら、加藤久典 シスチンの生体における定量とその応用 Food Style 21, 16(7), 31-35 (2012)

佐藤隆一郎、加藤久典(編集)「食べ物と健康」(吉田勉監修)学文社 (2012)

佐藤隆一郎、加藤久典(編集)「基礎栄養学」(吉田勉監修)学文社 (2012)

2011

原著論文M

Otani, L., Ogawa, S., Zhao, Z., Nakazawa, K., Umehara, S., Yoshimura, E., Chang, S.-J. and Kato, H. An Optimized Method for the Determination of Free L-Cysteine in Rat Plasma by High-Performance Liquid Chromatography Using the Derivatization Reagent 4-Aminosulfonyl-7-Fluoro-2,1,3-Benzoxadiazole. Biosci. Biotechnol. Biochem. 75, 2119-2124 (2011)

Jia, H., Ren, H., Deng, C., Kato, H. and Endo, H. Evaluation of the antioxidant potential of Chinese parsley (Coriandrum sativum) as compared with a synthetic antioxidant in diet. Int. J. Food Prop. in press.

Jia, H., Ren, H., Deng, C., Kato, H. and Endo, H. Antioxidant potential of Western parsley (Petroselinum crispum) extract and its effects on oxidative stabilities of food during storage. J. Food Biochem. in press

Wu, T., Sun, L., ZhuGe, F, Guo, X., Zhao, Z., Tang, R., Chen, Q., Chen, L., Kato, H. and Fu, Z. Differential roles of breakfast and supper in rats of a daily three-meal schedule upon circadian regulation and physiology. Chronobiol. Int. 28, 890-903

Takahashi, S., Masuda, J., Shimagami, H., Ohta, Y., Kanda, T., Saito, K. and Kato, H. Mild caloric restriction up-regulates the expression of prohibitin: A proteome study. Biochem. Biophys. Res. Commun. 405, 462-467

Ono, T., Morishita, S., Fujisaki, C., Ohdera, M., Murakoshi, M., Iida, N., Kato, H., Miyashita, K., Iigo, M., Yoshida, T., Sugiyama, K. and Nishino, H. Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat. Brit. J. Nutr. 105, 200-211
.
 Wu, T., Ni, Y., Zhue, F., Sun, L., Xu, B., Kato, H. and Fu, Z. Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney. J. Exp. Biol. 214 (Pt. 8), 1257-1263

著書・総説

Kato, H., Takahashi, S. and Saito, K. Omics and integtrated omics for the promotion of food and nutrition science. J. Trad. Comp. Med. 1, 25-30 (2011)
 
加藤久典 分子栄養学―遺伝子の働きから探る食品機能、バイオテクニシャン、19 (2)、6-14 (2011)

2010

原著論文

Dong, Y., Wu, T., Ni, Y.H., Kato, H., Fu, Z.W. Effect of fasting on the peripheral circadian gene expression in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol.298, 635-641

Wu, T., Ni, Y., Dong, Y., Kato, H. and Fu, Z.W. Regulation of circadian gene expression in the kidney by light and food cues in rats. Biol. Rhythm Res. 41, 41-47

Saito, K., Ohta, Y., Sami, M., Kanda, T. and Kato, H. Effect of mild restriction of food intake on gene expression profile in the liver of young rats: reference data for in vivo nutrigenomics study. Brit. J. Nutr. 104, 941-950

Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y. and Abe, K. Dietary iron deficiency induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study. Physiol. Genomics. 42,149-156

Wu, T., Ni, Y., Kato, H. and Fu, Z. Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats. Chronobiol. Int., 27, 1-18.

Toyoshima, Y, Tokita, R., Ohne, Y., Hakuno, F., Noguchi, T., Minami, S., Kato, H. and Shin-Ichiro Takahashi, S.I. Dietary protein deprivation up-regulates insulin signaling and inhibits gluconeogenesis in rat liver. J. Mol. Endocrinol.45, 329-340.

著書・総説

矢ヶ崎一三、末安俊明、河秉瑾、伊東克晃、米澤貴之、加藤久典 大豆イソフラボンによるインスリン抵抗性の克服とトランスクリプトームおよびプロテオーム解析による機能解明(第二報)、大豆たん白質研究、13, 23-29 (2010)

Abe, K., Kato, H., Yasuoka, A. and Nakai, Y. Genomics applied to nutrients and functional foods in Japan: State of the art. In: Genomics, proteomics, and metabolomics in nutraceuticals and functional foods. Bagchi, D., Lau, F.C. and Bagchi, M (eds) Wiley-Blackwell, U.S.A. pp127-154

加藤久典 1.9 トランスクリプトーム解析 (第5章大豆の機能性、第1節タンパク質の機能性)「大豆のすべて」(喜多村啓介他編集)、サイエンスフォーラム、pp185-188

高橋伸一郎、竹中麻子、豊島由香、木村久美、加藤久典、福島俊明、山中大介、伯野史彦、南史朗、岩下光利 発達と成長を司るホルモン、インスリン様成長因子 日本未熟児新生児学会雑誌、22, 19-25

加藤久典 第12章 網羅的遺伝子発現解析を利用した食品の安全性評価、「食の安全科学の展開-食のリスク予測と制御に向けて」(東京大学食の安全研究センター編)、シーエムシー出版、pp98-102

Srinivasan, V., Pandi-Perumal, S.R., Spence, W., Kato, H. and Cardinali, D.P. Melatonin in septic shock: Some recent concepts. J. Crit. Care, 25, 656.e1-656.e6

加藤久典、斉藤憲司 第6節 食品データベース(第4章 食品分野への応用)、「バイオチップ実用化ハンドブック」(金子周一、堀池靖浩編)、エヌ・ティー・エス、pp346-352

加藤久典 4章5 窒素化合物の代謝 「現代栄養学を理解するための分子生物学入門」 (加藤茂明編著)光生館 pp106-114

大谷りら、加藤久典、村上哲男 胎内の低栄養環境で生じる高血圧の発症機序 医学のあゆみ、235, pp833-837

2009

原著論文

Otani, L., Ninomiya, T., Murakami, M., Osajima, K., Kato, H. and Murakami, T. Sardine peptide with angiotensin I converting enzyme inhibitory activity improves glucose tolelance in stroke-prone spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 73, 2203-2209

Wu, T., Dong, Y., Yang, Z.Q., Kato, H., Ni, Y.H., Fu, Z.W. Differential resetting process of circadian gene expression in rat pineal glands after the reversal of the light/dark cycle via a 24-h light or dark period transition. Chronobiol. Int. 26, 793-807

Hirao, T., Watanabe, S., Temmei, Y., Hiramoto, M. and Kato, H. Qualitative PCR methods for detecting major food allergens (peanut, soybean, and wheat) by using internal transcribed spacer region. J. AOAC Int. 92, 1464-1472

著書・総説

加藤久典 第7章(訳)高齢者を含む成人と妊婦、授乳婦のタンパク質必要量「タンパク質・アミノ酸の必要量 WHO/FAO/UNU合同専門協議会報告」(日本アミノ酸学会翻訳小委員会)医歯薬出版 pp79-102

矢ケ崎一三、末安俊明、河秉瑾、長岡真聡、米沢貴之、 加藤久典 「大豆イソフラボンによるインスリン抵抗性の克服とトランスクリプトーム解析による機能解明」 (第一報) 大豆たん白質研究、12、pp22-26

2008

原著論文

Wu, T., Jin, Y.X., Kato, H. and Fu, Z.W. Light and food signals cooperate to entrain the rat pineal circadian system. J. Neurosci. Res. 86, 3246-3255

Niwa, Y., Nishiyama, C., Nakano, N., Kamei, A., Kato, H., Kanada, S., Ikeda, S., Ogawa, H. and Okumura, K. Opposite effects of PU.1 on mast cell stimulation. Biochem. Biophys. Res. Commun. 375, 95-100

Wu, T., Jin, Y.X., Ni, Y.H., Zhang, D.P., Kato, H. and Fu, Z.W. Effects of light cues on re-entrainment of the food-dominated peripheral clocks in mammals. Gene, 419, 27-34

Nakai, N., Hashida, H., Kadota, K., Minami, M., Shimizu, K., Matsumoto, I., Kato H. and Abe, K. Genes related to the ubiquitin-proteasome system are up-regulated in the brown adipose tissue of 24 h-fasted rats. Biosci. Biotechnol. Biochem. 72, 139-148

著書・総説

Hirao, T., Watanabe, S., Hiramoto, M., Taguchi, H., Temmei, Y. and Kato, H. Qualitative and quantitative PCR methods for detecting food allergens by using internal transcribed spacer region. J. Clin. Biochem. Nutr. 43(S1), 227-231

Kato, H. Nutrigenomics: the cutting edge and Asian perspectives. Asia Pac. J. Clin. Nutr. 17(S1), 12-15

2007

著書・総説

加藤久典、中井雄治、阿部啓子 1.ゲノミクス、プロテオミクス、メタボロミクスおよびシステムバイオロジーと、その栄養学へのアプローチ(訳)「最新栄養学 第9版」(木村修一、小林修平翻訳監修)建帛社、pp3-20

加藤久典、辻真之介 コレステロール負荷時における大豆たん白質摂取の効果のトランスクリプトーム解析、大豆たん白質研究、10, 76-82

加藤久典 第1編 第5章 抗肥満食品のマイクロアレイ解析 「抗肥満食品・素材の開発と応用展開」(大澤俊彦監修)シーエムシー出版、pp59-68

西山真, 加藤久典, 吉田稔, 山口五十麿, 宮川都吉, 小鹿一, 小梅枝正和, 日岡康恵 電子投稿審査システムの導入とその影響:日本農芸化学会の経験. 情報管理、50, 429-436

加藤久典、小林進、勝谷友宏、三谷康正 ニュートリゲノミクスの新潮流-テーラーメード栄養を身近なものに、バイオサイエンスとインダストリー、65, 19-23

加藤久典、第IV編 機能性食品とニュートリゲノミクス-3.実施例、同-5.安全性ゲノミクス「機能性食品の事典」、(荒井綜一ら編)朝倉書店、pp394-399, pp428-430

加藤久典、林裕三、高橋迪雄、古屋茂樹、岸恭一、門脇基二 進化の観点からアミノ酸栄養を考える、日本栄養・食糧学会誌、60, 151-166

加藤久典 第5章 アミノ酸機能のニュートリゲノミクス解析 「アミノ酸の機能特性-ライフサイエンスにおける新しい波-」(日本栄養・食糧学会監修)建帛社、pp171-187

加藤久典、第7章 アミノ酸による遺伝子発現の調節 「タンパク質・アミノ酸の新栄養学」(岸恭一、木戸康博編)講談社、pp82-94

野口忠、加藤久典、大石祐一、第2章 タンパク質・アミノ酸代謝 「タンパク質・アミノ酸の科学」(日本必須アミノ酸協会編)工業調査会、pp65-115

2006

原著論文

Hirao, T., Hiramoto, M., Imai, S. and Kato, H. A novel PCR method for quantification of buckwheat using a unique internal standard material. J. Food. Protect. 69, 2478-2486

Ohta, Y., Sami, M., Kanda, T., Saito, K., Osada, K. and Kato, H. Gene expression analysis of the anti-obesity effect by apple polyphenols in rats fed a high fat diet or a normal diet. J. Oleo Sci. 55, 305-314

Narasaka, S., Endo, Y., Fu, ZW., Moriyama, M., Arai, S., Abe, K. and Kato, H. Safety evaluation of hypoallergenic wheat flour using a DNA microarray. Biosci. Biotechnol. Biochem. 70, 1464-1470

著書・総説

加藤久典、辻真之介、食生活を視野に入れた大豆たん白質機能のニュートリゲノミクス解析、大豆たん白質研究、9, 102-107 (2006)

加藤久典、7.2.食品機能のDNAマイクロアレイ解析の具体例、「アンチエイジングと機能性食品」(吉川敏一、大澤俊彦編)シーエムシー出版、pp214-220

加藤久典、DNAチップを用いた食品の機能性評価、ジャパンフードサイエンス、45, 70-76

加藤久典、吉澤史昭、2.5.2.タンパク質の生合成 「栄養・食糧学データハンドブック」(日本栄養・食糧学会編)同文書院、pp87-90

2005

原著論文

Saito, K., Arai, S. and Kato, H. A nutrigenomics database - Integrated repository for publications and associated microarray data in nutrigenomics research. Brit. J. Nutr. 94, 493-495

Ohne, Y., Toyoshima, Y. and Kato, H. Disruption of the availability of amino acids induces a rapid reduction of serine phosphorylation of insulin receptor substrate-1 in vivo and in vitro. Biosci. Biotechnol. Biochem. 69, 989-998

Tachibana, N., Matsumoto, I., Fukui, K., Arai, S., Kato, H., Abe, K. and Takamatsu, K. Intake of soy protein isolate alters hepatic gene expression in rats. J. Agric. Food Chem. 53, 4253-4257

Hirao, T., Imai, S., Sawada, H., Shiomi, N., Hachimura, S. and Kato, H. PCR method for detecting trace amounts of buckwheat (Fagopyrum spp.) in food. Biosci. Biotechnol. Biochem. 69, 724-731

著書・総説

Kato, H., Saito, K. and Kimura, T. A perspective on DNA microarray technology in food and nutritional science. Curr. Opin. Clin. Nutr. Metab. Care, 8, 516-522

Matsuzaki, K., Kato, H., Sakai, R., Toue, S., Amao, M. and Kimura, T. Transcriptomics and metabolomics of dietary leucine excess. J. Nutr. 135, 1571S-1575S

小田裕昭、加藤久典、関泰一郎(編著)「健康栄養学-健康科学としての栄養生理化学-」共立出版

加藤久典 5.4. 内分泌系における食情報の受容と伝達 「食品の科学」(上野川修一、田之倉優編)東京化学同人、pp134-138

加藤久典 栄養学の新しい潮流-分子栄養学からニュートリゲノミクスへ、食品と技術、404, 1-9

加藤久典 タンパク質の機能性・安全性予測のためのトランスクリプトミクス、日本食品新素材研究会誌 7, 1-7

加藤久典 食餌タンパク質の機能解析とトランスクリプトミクス、日本臨床栄養学会雑誌26, 207-211

2004

原著論文

Toyoshima, Y., Ohne, Y., Takahashi, S.-I., Noguchi, T. and Kato, H. Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle. J. Mol. Endocrinol. 32, 519-531

著書・総説

太田豊、長田恭一、船山誠、佐見学、神田智正、加藤久典、ジーンチップによる肥満誘導食摂取ラットに与えるポリフェノール素材投与効果の解析.脂質生化学研究 46, 160-163

Kato, H., Narasaka, S., Endo, Y., Abe, K. and Arai, S. DNA microarray analyses of the effects of dietary proteins. Biofactors 21, 11-13

加藤久典 第8章タンパク質(共著、野口忠)、第14章消化・吸収 「基礎栄養学」(倉田忠男他編)東京化学同人 pp80-107, pp184-197

加藤久典 第15章 栄養と遺伝子科学(訳)「ヒューマン・ニュートリション、基礎・食事・臨床」(細谷憲政監修)医歯薬出版 pp299-309

2003

原著論文

Imae, M., Fu, ZW., Yoshida, A., Noguchi, T. and Kato, H. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J. Mol. Endocrinol.30, 253-262

Oishi, Y., Kato, H. and Noguchi, T. Dietary protein is a potent regulator of the hyaluronan synthase gene in rat skin. Biosci. Biotechnol. Biochem. 67, 736-742

著書・総説

加藤久典 15章 窒素の代謝II:分解(訳)「マッキー生化学 第3版」(市川厚監修)化学同人 pp459-484

加藤久典 3.3.3 a. 分子栄養学、3.3.3.b.2) ホルモンと栄養 「農芸化学の事典」(鈴木昭憲、荒井綜一編)朝倉書店 pp424-426, pp429-431
Kato, H. and Kimura, T. Evaluation of the effects of the dietary intake of proteins and amino acids by DNA microarray technology. J. Nutr. 133, 2073S-2077S

2002

原著論文

Fu,ZW., Yoneyama, M., Noguchi, T. and Kato , H. Response of the IGF system to vitamin A depletion and repletion in rats. J. Nutr. Sci. Vitaminol.48, 453-460 

Endo, Y., Fu, Z.W., Abe, K., Arai, S. and Kato, H. Dietary protein quantity and quality affect rat hepatic gene expression. J. Nutr.132, 3632-3637

Oishi, Y., Fu, Z.W., Ohnuki, Y., Kato, H. and Noguchi, T. Molecular basis of the alteration in skin-collagen metabolism in response to in vivo dexamethasone treatment: Effects on syntheses of collagen type I and III, collagenase, and TIMPs. Brit. J. Dermatol.147, 859-868

Tachibana, T., Tanaka, S., Furuse, M., Hasegawa, S., Kato, H. and Sugahara, K. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks. Brit. Poultry Sci. 43, 122-126

Oishi, Y., Fu, Z.W., Ohnuki, Y., Kato, H. and Noguchi, T. Effects of protein deprivation on a1(I) and a1(III) collagen and its degrading system in rat skin. Biosci. Biotechnol. Biochem. 66, 117-126

Fu, Z.W., Inaba, M., Noguchi, T. and Kato, H. Molecular cloning and circadian regulation of cryptochrome genes in the Japanese quail (Coturnix coturnix japonica). J. Biol. Rhythms17, 14-27

著書・総説

加藤久典 タンパク質代謝の分子栄養学 「分子栄養学 栄養素と生活習慣病の分子生物学」(柿沼淳司編著)光生館 pp50-64

2001

原著論文

Fu, Z.W., Kato, H, Kotera, N., Noguchi, T., Sugahara, K. and Kubo, T. Regulation of hydroxyindole-O-methyltransferase gene expression in Japanese quail (Coturnix coturnix japonica). Biosci. Biotechnol. Biochem.65, 2504-2511

Matsukawa, T., Inoue, Y., Oishi, Y., Kato, H. and Noguchi, T. Up-regulation of upstream stimulatory factors by protein malnutrition and its possible role in regulation of the IGF-binding protein-1 gene. Endocrinology 142, 4643-4651

Fu, ZW., Noguchi, T. and Kato, H. Differential regulation of IGFBP-2 and IGFBP-5 gene expression by vitamin A status in Japanese quail. Am. J. Physiol.281, E138-E146

Fu, ZW., Kubo, T., Sugahara, K., Noguchi, T. and Kato, H. Retinoid nutritional status differently affects the expression of quail RARb isoform transcripts in a tissue-specific manner. J. Endocrinol. 169, 281-290

Fu, ZW., Noguchi, T. and Kato, H. Vitamin A deficiency reduces IGF-I gene expression and increases IGF-I receptor and insulin receptor gene expression in tissues of Japanese quail (Coturnix coturnix japonica). J. Nutr.131, 1189-1194

Fu, ZW, Kubo, T., Noguchi, T. and Kato, H. Developmental changes in the mRNA levels of IGF-I and its related genes in the reproductive organs of Japanese quail (Coturnix coturnix japonica) Growth Horm. IGF Res.11, 24-33

Fu, ZW, Kubo, T., Sugahara, K, Noguchi, T. and Kato, H. Cloning of cDNAs encoding quail (Coturnix coturnix japonica) retinoic acid receptor b isoforms and changes in their gene expression during gonadotropic growth. Biol. Reprod. 64, 231-241

著書・総説

加藤久典 分子生物学的手法 「動物栄養試験法」(石橋晃監修) pp380-394

2000

原著論文

Tachibana, T., Uchimura, D., Kato, H., Kubo, T. and Sugahara, K. Extracellular norepinephrine in the medial hypothalamus increases during feeding in chicks: A microdialysis study. Comp. Biochem. Physiol. 127A, 331-338

Imae, M., Inoue, Y., Fu, ZW., Kato, H. and Noguchi, T. Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors. J. Endocrinol.167, R1-R5

Fu, ZW., Kato, H. Sugahara, K and Kubo, T. Retinoic acid accelerates the development of reproductive organs and egg production in Japanese quail (Coturnix coturnix japonica). Biol. Reprod. 63, 1795-1800

Kato, H., Okubo, Y., Matsumura, Y., Roberts, C.T., Jr., Sugahara, K. and LeRoith, D. The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor. Biosci. Biotechnol. Biochem.64, 903-906

著書・総説

加藤久典 初代培養肝細胞「タンパク質代謝研究法」(野口忠、舩引龍平、門脇基二編著)学会出版センター pp115-128

加藤久典 内分泌調節機能 「食品機能研究法」(篠原和毅、鈴木建夫、上野川修一編)、光琳 pp103-105

1999

原著論文

Sugahara, K., Shimoyama, Y., Kato, H. and Kubo, T. Feeding a lysine-free diet decreases food intake without changes in hypothalamic monoamine concentrations in growing chickens. Anim. Sci. Technol. (Jpn.)70, 484-489

Fu, ZW., Kato, H., Kotera, N., Sugahara, K. and Kubo, T. Regulation of the expression of serotonine N-acetyltransferase gene in Japanese quail (Coturnix japonica): (II) Effect of vitamin A deficiency. J. Pineal Res.27, 34-41

Kato, H., Fu, ZW., Kotera, N., Sugahara, K. and Kubo, T. Regulation of the expression of serotonine N-acetyltransferase gene in Japanese quail (Coturnix japonica): (I) Rhythmic pattern and effect of light. J. Pineal Res.27, 24-33

1998

原著論文

Tsuchiya, T., Nagao, Y., Ozawa, A., Matsumoto, M., Sugahara, K., Kubo, T. and Kato, H. Decrease of the obese gene expression in bovine subcutaneous adipose tissue by fasting. Biosci. Biotechnol. Biochem. 62, 2068-2069

Fu, ZW., Kato, H., Sugahara, K. and Kubo, T. Circadian rhythm of pineal melatonin contents in silky chicks. Jpn. Poult. Sci. 35, 55-59

Fu, ZW., Kato, H., Sugahara, K. and Kubo, T. Vitamin A deficiency reduces the responsiveness of pineal gland to light in Japanese quail (Coturnix japonica). Comp. Biochem. Physiol. 119A, 593-598

1997

原著論文

傅正偉、近藤康、岩崎信久、加藤久典、菅原邦生、久保辰雄 ニワトリヒナ松果体中メラトニンの抽出法と高速液体クロマトグラフィーによる定量法、日本畜産学会報、68, 1154-1160

Shim, S., Fu, ZW., Kato, H. and Tanaka, H. Diurnal changes in the enzyme activity and the messenger RNA level of pineal serotonin N-acetyltransferase in normal and hereditary microphthalmic rats. Biosci. Biotechnol. Biochem. 61, 2113-2115.

Fu, ZW., Kubo, T. and Kato, H. Analyses of serotonin N-acetyltransferase mRNA content in rat pineal grand and testis by an improved assay system - Micro lysate assay. Anim. Sci. Technol. (Jpn.) 68, 893-896

Fu, ZW., Ohara, S., Kato, H., Sugahara, K. and Kubo, T. Retinoic acid accelerates the testicular maturation in Japanese quail. Anim. Sci. Technol (Jpn) 68, 420-422

Najjar, S.M., Blakesley, V.A., Li Calzy, S., Kato, H., LeRoith, D. and Choice, C.V. Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: Role for the C-terminal domain of the b-subunit. Biochemistry 36, 6827-6834

著書・総説

加藤久典、傅正偉 遺伝子レベルでの栄養研究-多様なmRNA種をつくる遺伝子について、日本栄養・食糧学会誌、50, 377-379

加藤久典 IGF-Iの作用発現機構に関する分子生物学的研究、日本農芸化学会誌 71, 1141-1146

1996

原著論文

Matsumura, Y., Domeki, M., Sugahara, K., Kubo, T., Roberts, C.T., Jr., LeRoith, D. and Kato, H. Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens. Biosci. Biotechnol. Biochem. 60, 979-982

著書・総説

Kato, H., Noguchi, T. and LeRoith, D. Nutritional regulation of gene expression of IGFs and their related proteins. In: Gene expression and nutrition: From cells to whole body. Muramatsu, T. (ed) Research Signpost, India, pp25-43

1995

原著論文

Stannard, B., Blakesley, V.A., Kato, H., Roberts, C.T., Jr. and LeRoith, D. Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis. Endocrinology 136, 4918-4924

Surmacz, E., Sell, C., Swantek, J., Kato, H., Roberts, C.T., Jr., LeRoith, D. and Baserga, R. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Exp. Cell. Res.218, 370-380

Blakesley, V.A., Kato, H., Roberts, C.T., Jr. and LeRoith, D. Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function. J. Biol. Chem. 270, 2764-2769

1994

原著論文

Mastick, C.C., Kato, H., Roberts, C.T., Jr., LeRoith, D. and Saltiel, A.R. Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. Endocrinology 135, 214-222

Faria, T.N., Blakesley, V.A., Kato, H., Stannard, B., LeRoith, D. and Roberts, C.T.,Jr. Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptor function. J. Biol. Chem. 269, 13922-13928

Kato, H., Faria, T.N., Stannard, B., Roberts, C.T.,Jr. and LeRoith, D. Essential role of tyrosine residues 1131, 1135 and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Mol. Endocrinol. 8, 40-50

著書・総説

Kato,H., Faria, T.N., Blakesley, V., Roberts, C.T., Jr. and LeRoith, D. Pathological alterations in various components of the insulin-like growth factor signalling system. In: Molecular basis of endocrine diseases (Series: Frontiers in endocrinology 7) Isidori, A., New, M.I., Sesma, C.P.(eds) Ares-Serono Symposia Publications, Rome, pp105-118

1993

原著論文

Takenaka, A., Hirosawa, M., Mori, M., Yamada, S., Miura, Y., Kato, H., Takahashi, S.I. and Noguchi, T. Effect of protein nutrition on the messenger RNA content of insulin-like growth factor binding protein-1 in liver and kidney of rats. Brit. J. Nutr.69, 73-82

Kato, H., Faria, T.N., Stannard, B., Levy-Toledano, R., Taylor, S.-I., Roberts, C.T., Jr. and LeRoith, D. Paradoxical biological effects of overexpressed insulin-like growth factor-I receptors in Chinese hamster ovary cells. J. Cell. Physiol. 156, 145-152

Kato, H., Faria, T.N., Stannard, B., Roberts, C.T., Jr. and LeRoith, D. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of IGF-I mimetic antibody (aIR-3). J. Biol. Chem. 268, 2655-2661

著書・総説

LeRoith, D., Werner, H., Faria, T.N., Kato, H., Adamo, M. and Roberts, C.T., Jr. Insulin-like growth factor receptors - Implications for nervous system function. In: Role of insulin-like growth factors in the nervous systems. Raizada, M.K. and LeRoith, D. (eds.) New York Academy of Science, New York, pp23-32

LeRoith, D., Adamo, M., Kato, H. and Roberts, C.T., Jr. Divergence of insulin and insulin-like growth factor-I signalling pathways. In: Lessons from Laron syndrome. Laron, Z. and Parks, J.S. (eds.) Karger, Basel, pp346-358

1992

原著論文

Miura, Y., Higashi, Y., Kato, H., Takahashi, S.-I. and Noguchi, T. Effects of dexamethasone on the production of insulin-like growth factor-I and insulin-like growth factor binding proteins in primary cultures of rat hepatocytes. Biosci. Biotechnol. Biochem. 56, 1396-1400

Miura, Y., Kato, H. and Noguchi, T. Effect of dietary proteins on insulin-like growth factor-I (IGF-I) messenger ribonucleic acid content in rat liver. Brit. J. Nutr. 67, 257-265

著書・総説

LeRoith, D., McGuiness, M., Shemer, J., Stannard, B., Lanau, F., Faria, T.N., Kato, H., Werner, H., Adamo, M. and Roberts, C.T.,Jr. Insulin-like growth factors. Biosignals 1, 173-181

1991

原著論文

Takenaka, A., Miura, Y., Mori, M., Hirosawa, M., Kato, H. and Noguchi, T. Distribution of messenger RNAs of insulin-like growth factor (IGF)-binding proteins-1 and -3 between parenchymal and nonparencymal cells in rat liver. Agric. Biol. Chem. 55, 1191-1193

Umezawa, T., Kajikawa, M., Ohsawa, Y., Miura, Y., Kato,H. and Noguchi, T. Effect of protein deprivation on insulin-like growth factor-binding proteins in rats. Brit. J. Nutr. 66, 105-116

著書・総説

Kato, H., Umezawa, T., Miura, Y. and Noguchi, T. The effect of quantity and nutritional quality of dietary proteins on plasma concentration of insulin-like growth factor binding proteins (IGFBP) and the saturability of IGFBP with endogenous IGF-I. Adv Exp Med Biol. 293, 171-178

1990

原著論文

Takahashi, S., Kajikawa, M., Umezawa, T., Takahashi, S.-I., Kato, H., Miura, Y., Nam, T.J., Noguchi, T. and Naito, H. Effect of dietary proteins on the plasma immunoreactive insulin and insulin-like growth factor-I/somatomedin C concentration in the rat. Brit. J. Nutr. 63, 521-534

Nam, T.J., Noguchi, T., Funabiki, R., Kato, H., Miura, Y. and Naito, H. Correlation between the urinary excretion of acid soluble peptides, fractional synthesis rate of whole body proteins, and plasma insulin-like growth factor-I/somatomedin C concentration in the rat. Brit. J. Nutr. 63, 515-520

Kato, H., Takenaka, A., Miura, Y., Nishiyama, M. and Noguchi, T. Evidence of introduction by molecular cloning of artificial inverted sequence at the 5' terminus of the sense strand of rat insulin-like growth factor-I cDNA. Agric. Biol. Chem. 54, 2225-2230

Kato, H., Okoshi, A., Miura, Y. and Noguchi, T. A new cDNA clone relating to larger molecular species of rat insulin-like growth factor-I mRNA. Agric. Biol. Chem. 54, 1599-1601

1989

原著論文

Takahashi, S.-I., Ohishi, Y., Kato, H., Noguchi, T., Naito, H. and Aoyagi, T. The effects of bestatin, a microbial aminopeptidase inhibitor, on epidermal growth factor- induced DNA synthesis and cell division in primary cultured hepatocytes of rats. Exp. Cell Res. 183, 399-412

Takenaka, A., Tayama, T., Takahashi, S.-I., Kato, H., Noguchi, T. and Naito, H. Microinjection of endogenous proteins into primary cultures of rat hepatocytes and the degradation of the injected proteins. Int. J. Biochem. Cell Biol. 21, 497-508

Kato, H., Takahashi, S.-I., Takenaka, A., Funabiki, R., Noguchi, T. and Naito, H. Degradation of endogenous proteins and internalized asialofetuin in primary cultured hepatocytes of rats. Int. J. Biochem.Cell Biol. 21, 483-495

著書・総説

Kato, H., Miura, Y., Okoshi, A., Umezawa, T., Takahashi, S.-I. and Noguchi, T. Dietary and hormonal factors affecting the mRNA level of IGF-I in rat liver in vivo and in primary cultures of rat hepatocytes. In: Molecular and cellular biology of insulin-like growth factors and their receptors. LeRoith, D. and Raizada, M. (eds.) Plenum, New York, pp125-128

Noguchi, T., Tayama, T., Takenaka, A., Takahashi, S.-I., Kato,H. and Naito, H. Microinjection of endogenous and exogenous proteins into primary cultured hepatocytes and degradation of the injected proteins. In: Intracellular proteolysis: Mechanism and regulations. Katunuma, N. and Kominami, E (eds.) Japan Scientific Societies Press, Tokyo, pp485-487

Kato, H., Takahashi, S.-I., Funabiki, R., Noguchi, T. and Naito, H. Mechanism and rate of degradation of short- and long-lived proteins in primary cultured rat hepatocytes. In: Intracellular proteolysis: Mechanism and regulations. Katunuma, N. and Kominami, E (eds.)

1988

原著論文

Takahashi, S.-I., Kato, H., Seki, T.-I., Takahashi, A., Noguchi, T. and Naito, H. Intermediate peptides of insulin degradation in liver and cultured hepatocytes of rats. Int. J. Biochem. Cell Biol. 20, 1369-1380

Noguchi, T., Nam, T.J., Kato, H. and Naito, H. Further studies on the nutritional factors affecting the urinary excretion of acid-soluble peptides in rats. Brit. J. Nutr. 60, 321-337

1987

原著論文

Takahashi, S.-I., Kato, H., Takahashi, A., Noguchi, T. and Naito, H. Mode of action of bestatin and leupeptin to induce the accumulation of acid soluble peptides in rat liver in vivo and the properties of the accumulated peptides. The important role of bestatin- and leupeptin- sensitive proteases in the protein degradation pathway in vivo. Int. J. Biochem. Cell Biol. 19, 401-412

著書・総説

加藤久典 インスリン様成長因子とタンパク質代謝 日本農芸化学会誌 16, 1305-1308

1985

原著論文

Takahashi, S.-I., Kato, H., Seki, T.-I., Noguchi, T., Naito, H., Aoyagi, T. and Umezawa, H. Bestatin, a microbial aminopeptidase inhibitor inhibits DNA synthesis induced by insulin or epidermal growth factor in primary cultured rat hepatocytes. J. Antibiot. 38, 1767-1773 (1985)

学会発表

2010

Japan-New Zealand Joint Workshop on “Functional Food”(2010/10/12)

12th Japanese-Swiss Meeting on Biotechnology and Bioprocess Development(2010/10/10-12)

日本農芸化学会関西支部シンポジウム(2010/10/2)

日本アミノ酸学会第4回学術大会(2010/9/16-17)

核酸・核 タンパク機能性研究会 第5回学術集会(2010/8/6)

第64回日本栄養・食糧学会大会(2010/5/21-23)

日本農芸化学会2010年度大会(2010/3/27-30)

2009

日本アーユルヴェーダ学会総会(2009/12/12)

第32回日本分子生物学会年会(2009/12/9-12)

第3回食品薬学シンポジウム(2009/11/12)

19th International Congress of Nutrition (2009/10/4-9)

日本アミノ酸学会 第3回学術大会(2009/09/29-30)

第84回日本栄養・食糧学会関東支部会(2009/09/19)

核酸・核タンパク機能性研究会 第4回学術集会(2009/07/31)

Nutrigenomics Database