Dr. P. K Hashim was born in Kozhikode, Kerala, India in 1986. He received his M.Sc Degree in Organic Chemistry (2008) from Aligarh Muslim University, Utter Pradesh, India and worked as lecturer in Chemistry for one year in higher secondary level, Kerala, India. In 2012 he completed his Ph. D from Hokkaido University, Sapporo, Japan under the guidance of Prof. Nobuyuki Tamaoki with thesis entitled “Induction of molecular chirality by Polarized or non-polarized light in azobenzene derivatives”. Currently he is a Post-doctoral researcher at the University of Tokyo, Japan in the group of Prof. Takuzo Aida. His present research interest is to develop carriers of siRNA for the efficient drug delivery system using synthetic supramolecular approach.

Ongoing Projects/Grants

• Design and construction of Chaperonin GroEL-based nanostructures. CONCERT-Japan International grant (Co-PI; JPMJSC18C1; 2019–2021)

• Precise coating of DNA origami nanostructures via ‘template polymerization’. JSPS KAKENHI Early Carrier Scientists (PI; 18K14270; 2018-2020).

• Development of protein nanocaplets via ‘template polymerization’ for intracellular delivery of anionic proteins.

• Biomolecular machine immobilized nanoparticles and its cluster for ATP-triggered robotics applications.

• Supramolecular polymerization of biomolecules: fabrication of multidimensional protein-based architectures for biomedical applications. Novel Hybrid Materials; Supramolecular Assembly of Chaperonine GroEL on Gold Nanoparticle.

Education

B.Sc.   Farook College, University of Calicut, Kerala, India (June 2006)

M.Sc.  Aligarh Muslim University, UP, India (June 2008)

Ph. D  Hokkaido University, Sapporo, Japan (September 2012)

Professional Appointments

2008         : Lecturer in Chemistry (higher secondary), Triumphant Institute of Management studies, India.

2009         : Lecturer in Chemistry, Markaz Arts and Science College, University of Calicut, Kerala, India.

2012–2017: Project Researcher, The University of Tokyo

2017–2018: Project academic specialist, The University of Tokyo

2018–Now: Project Researcher, Department of Chemistry and Biotechnology, The University of Tokyo

2017–Now: Visiting Researcher, Innovation Center of Nanomedicine, Kawasaki, Japan

Awards

2008 Summer Research Fellowship, Indian Academy of Science

2017 Young Scientist Awards, Gordon Research Conference

2019 CSJ Presentation Awards, Annual Meeting of the Chemical Society of Japan

2019 Otsuka award, International symposium on nucleic acid chemistry, Japan

2021 Chemical Science, Nanoscale Advances, Nanoscale Horizons and Nanoscale Outstanding Oral Presentation Prize at ANNIC 2021

Publications

“Induction of Molecular Chirality by Circularly Polarized Light in Cyclic Azobenzene with a Photoswitchable Benzene rotor”

P. K Hashim, Reji Thomas and Nobuyuki Tamaoki

Chem. Eur. J. 2011, 17, 7304 – 7312.

“Induction of Point Chirality by E/Z Photoisomerization”

P. K Hashim and Nobuyuki Tamaoki

Angew. Chem. Int. Ed. 2011, 50, 11729 –11730.

Highlighted in Nature Chemistry, Vol 4, January 2012

Featured in Chemistry views, November 2011

“Chirality Induction by E-Z photoisomerization in [2,2]paracyclophane-bridged Azobenzene Dimer”

P. K. Hashim, M.C Basheer and Nobuyuki Tamaoki

Tetrahedron Lett. 2012, 54, 176 –178.

“Dynamic Induction of Enantiomeric Excess from a Prochiral Azobenzene Dimer Under Circularly Polarized Light”

K Rijeesh, P.K Hashim, Shin-ichiro Noro and Nobuyuki Tamaoki

Chem Sci. 2015, 6, 973 – 980.

“Reductively Cleavable Minimum Caplets for siRNA Delivery by Template-Assisted Oxidative Polymerization”

P.K Hashim, Kou Okuro, Shigekazu Sasaki, Yatsuka Hoashi and Takuzo Aida

J. Am. Chem. Soc. 2015, 137, 15608 – 15611.

“Guanidinium-Based “Molecular Glues” for Modulation of Biomolecular Functions”

Rina Mogaki, P. K. Hashim, Kou Okuro, and Takuzo Aida

Chem. Soc. Rev. 2017, 46, 6480 – 6491.

”Ultra-small, glutathione responsive nanocaplets prepared via templated-polymerization for gene and protein delivery”

P. K. Hashim, Kou Okuro, Takuzo Aida.  

J. Control. Release. 2017,  259, e5–e195

“Enantioselective Photochromism under Circularly Polarized Light”

P. K. Hashim and Nobuyuki Tamaoki

ChemPhotoChem 2019, 3, 1–10.

“Transferrin Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues”

Ai Kohata, P. K. Hashim, Kou Okuro and Takuzo Aida

J. Am. Chem. Soc. 2019, 141, 2862 – 2866.

”Supramolecular Polymerization: A Conceptual Expansion for Innovative Materials”

P. K. Hashim, Julian Bergueiro, E.W Meijer and Takuzo Aida.  

Prog. Polym. Sci. 2020, 105, 101250

Book Chapter

Nanomaterials in chemotherapy in the book “Biotechnology in Cancer: Diagnosis and Therapy”

P. K. Hashim and Anjeneyulu Dirisala.

Jenny Standford Publisher, 2021 (in press)

Dr. Hashim P. KAYAKALI

博士研究員

東京大学大学院工学系研究科

化学生命工学専攻

hashim＠macro.t.u-tokyo.ac.jp