研究成果（高田修治）

1. 研究成果
2. 公募研究A01 - 高田修治

1. 013

   Inoue M, Baba T, Takahashi F, Terao M, Miyabayashi K, Shima Y, Saito D, Sugiura K, Miura T, Takada S, Suyama M, Ohkawa Y, Morohashi K-I.

   "Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway."

   Commun Biol 2022 5: 974.

2. 012

   Nakagawa R, Takasawa K, Tsuji-Hosokawa A, Kawaji H, Murakawa Y, Takada S, Mikami M, Narumi S, Fukami M, Sreenivasan R, Maruyama T, Tucker E, Zhao L, Bowles J, Sinclair A, Koopman P, Hayashizaki Y, Morio T, Kashimada K.

   "Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency."

   Hum Mol Genet 2022 31: 2223-2235.

3. 011

   Tsuji-Hosokawa A, Ogawa Y, Tsuchiya I, Terao M, Takada S.

   "Human SRY expression at the sex-determining period is insufficient to drive testis development in mice."

   Endocrinology 2022 163: bqab217.

4. 010

   Kajioka D, Suzuki K, Matsushita S, Hino S, Sato T, Takada S, Isono K, Takeo T, Kajimoto M, Nakagata N, Nakao M, Suyama M, DeFalco T, Miyagawa S, Yamada G.

   "Sexual fate of murine external genitalia development: conserved transcriptional competency for male-biased genes in both sexes."

   Proc Natl Acad Sci USA 2021 118: e2024067118.

5. 009

   Kagami M, Hara-Isono K, Matsubara K, Nakabayashi K, Narumi S, Fukami M, Ohkubo Y, Saitsu H, Takada S, Ogata T.

   "ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance."

   Clin Epigenetics 2021 13: 119.

6. 008

   Hara S, Terao M, Tsuji-Hosokawa A, Ogawa Y, Takada S.

   "Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain."

   Hum Mol Genet 2021 30: 564–574.

7. 007

   Otsuka K, Matsubara S, Shiraishi A, Takei N, Satoh Y, Terao M, Takada S, Kotani T, Satake H, Kimura AP.

   "A testis-specific long noncoding RNA, Start, is a regulator of steroidogenesis in mouse Leydig cells."

   Front Endocrinol 2021 12: 665874.

8. 006

   Miyamoto Y, Torii T, Terao M, Takada S, Tanoue A, Katoh H, Yamauchi J.

   "Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods."

   Mol Biol Cell 2021 32: 769–787.

9. 005

   Ushijima K, Ogawa Y, Terao M, Asakura Y, Muroya K, Hayashi M, Ishii T, Hasegawa T, Sekido R, Fukami M, Takada S, Narumi S.

   "Identification of the first promote-rspecific gain-of-function SOX9 missense variant (p.E50K) in a patient with 46, XX ovotesticular disorder of sex development."

   Am J Med Genet A 2021 185: 1067–1075.

10. 004

    Akino R, Matsui D, Kawahara-Miki R, Amita M, Tatsumi K, Ishida E, Kang W, Takada S, Miyado K, Sekizawa A, Saito T, Kono T, Saito H.

    "Next-generation sequencing reveals downregulation of the Wnt signaling pathway in human dysmature cumulus cells as a hallmark for evaluating oocyte quality."

    Reprod Med 2021 in press.

11. 003

    Wakabayashi M, Tamura S, Kanzaki S, Kosugi M, Yoshimura Y, Ito T, Nagata K, Sato K, Takada S, Sekita Y, Kimura T.

    "Five multicopy family genes expressed during maternal to zygote transition are not essential for mouse development."

    Biochem Biophys Res Commun 2021 534: 752–757.

12. 002

    Akiba K, Narumi S, Nishimura R, Kato-Fukui Y, Takada S, Hasegawa Y, Fukami M.

    "SOX9 is co-localized with paraspeckle protein NONO in cultured murine Sertoli cells and features structural characteristics of intrinsically disordered proteins."

    Mol Reprod Dev 2020 87: 1124–1125.

13. 001

    Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H.

    "Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates."

    Elife 2020 9: e53608.