研究成果（長尾恒治）

1. 研究成果
2. 計画研究A01 - 長尾恒治

1. 013

   Masui O, Corbel C, Nagao K, Endo TA, Kezuka F, Diabangouaya P, Nakayama M, Kumon M, Koseki Y, Obuse C, Koseki H, Heard E.

   "Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages."

   Nat Cell Biol 2023 25: 134-144.

2. 012

   Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.

   "RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells."

   Commun Biol 2022 5: 1420.

3. 011

   Ichihara S, Nagao K, Sakaguchi T, Obuse C, Sado T.

   "SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice."

   Development 2022 149: dev200864.

4. 010

   Isobe SY, Hiraga SI, Nagao K, Sasanuma H, Donaldson AD, Obuse C.

   "Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action."

   Cell Rep 2021 36: 109383.

5. 009

   Miura H, Takahashi S, Shibata T, Nagao K, Obuse C, Okumura K, Ogata M, Hiratani I, Takebayashi SI.

   "Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing."

   Nat Protoc 2020 15: 4058–4100.

6. 008

   Hamanaka K, Šikrová D, Mitsuhashi S, Masuda H, Sekiguchi Y, Sugiyama A, Shibuya K, Lemmers RJLF, Goossens R, Ogawa,M, Nagao K, Obuse C, Noguchi S, Hayashi YK, Kuwabara S, Balog J, Nishino I, van der Maarel SM.

   "Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy."

   Neurology 2020 94: e2441–e2447.

7. 007

   Kinjo K, Nagasaki K, Muroya K, Suzuki E, Ishiwata K, Nakabayashi K, Hattori A, Nagao K, Nozawa RS, Obuse C, Miyado K, Ogata T, Fukami M, Miyado M.

   "Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency."

   Sci Rep 2020 10:10985.

   プレスリリース 先天性下垂体機能低下症の症例で新たな遺伝子変異を同定

8. 006

   Asakawa H, Kojidani T, Yang HJ, Ohtsuki C, Osakada H, Matsuda A, Iwamoto M, Chikashige Y, Nagao K, Obuse C, Hiraoka Y, Haraguchi T.

   "Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast."

   PLoS Genet 2019 15: e1008061.

9. 005

   Takahashi S, Miura H, Shibata T, Nagao K, Okumura K, Ogata M, Obuse C, Takebayashi SI, Hiratani I.

   "Genome-wide stability of the DNA replication program in single mammalian cells."

   Nat Genet 2019 51: 529–540.

10. 004

    Sakakibara Y, *Nagao K, Blewitt M, Sasaki H, Obuse C, *Sado T. (*Corresponding author).

    "Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice."

    Development 2018 145: dev166462.

11. 003

    Terui R, Nagao K, Kawasoe Y, Taki K, Higashi TL, Tanaka S, Nakagawa T, Obuse C, Masukata H, Takahashi TS.

    "Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1."

    Genes Dev 2018 32: 806–821.

12. 002

    Sakata Y*, Nagao K*, Hoki Y, Sasaki H, Obuse C, Sado T. (*equal contribution).

    "Defects in dosage compensation impact global gene regulation in the mouse trophoblast."

    Development 2017 144: 2784–2797.

13. 001

    Isobe SY, Nagao K, Nozaki N, Kimura H, Obuse C.

    "Inhibition of RIF1 by SCAI allows BRCA1-mediated repair."

    Cell Rep 2017 20: 297–307.