Our research focuses on understanding the molecular mechanism of membrane transport.
Membrane transport processes, including intracellular uptake, extracellular transport, signal transduction, energy production by respiration and photosynthesis, and environmental stress responses, are all essential to cellular life.
Therefore, we believe that studies on membrane transport not only contribute to basic science but also significantly lead to the development of a sustainable society by improving the functionality of microbial cell factories and the production efficiency of renewable resources.
Since one of the antibiotic resistance mechanisms of bacteria is the extracellular excretion of drugs, membrane transport of microorganisms is also of great interest in the fields of medicine and drug discovery.
In our laboratory, we use a unique “electrophysiological analysis system,” which we developed independently to study membrane transport. We also study membrane transport by molecular dynamics simulations using supercomputers such as “Fugaku”, which uses a membrane model close to an actual membrane created using our independently-developed lipid force field parameters. By making full use of these non-traditional methods, we aim to gain new insights into membrane transport.
Furthermore, based on the new findings obtained in this way, we also promote research aimed at contributing to society in various ways.