2018年
Enantioselective Total Synthesis of (+)-Anthecularin.
Y. Ogura, S. Okada, N. Mori, K. Ishigami, H. Watanabe; Org. Lett., 20, 3888-3891 (2018).
Synthetic studies on pseudolaric acid B: Construction of the trans-fused [5-7] ring system via Dieckmann codensation.
N. Mori, C. Mase, H. Watanabe, H. Takikawa, Tetrahedron Lett., 59, 2600-2063 (2018).
The membrane-bound O-acyltransferase Ale1 transfers an acyl moiety to newly synthesized 2-alkyl-sn-glycero-3-phosphocholine in yeast.
S. Morisada, Y. Ono, T. Kodaira, H. Kishino, R. Ninomiya, N. Mori, H. Watanabe, A. Ohta, H. Horiuchi, R. Fukuda, FEBS Lett., 592, 1829-1836 (2018).
Challenges for the Synthesis of Azadirachtin.
N. Mori, J. Synth. Org. Chem. Jpn., 76, 506-509 (2018).
Synthetic studies on optically active furofuran and diarylbutane lignans.
N. Mori, Biosci. Biotechnol. Biochem., 82, 1-8 (2018).
2017年
Structural Insights into the CotB2-catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
T. Tomita, S-Y. Kimu, K. Teramoto, A. Meguro, T. Ozaki, A. Yoshida, Y. Motoyoshi, N. Mori, K. Ishigami, H. Watanabe, M. Nishiyama, T. Kuzuyama, ACS Chem. Biol., 12, 1621-1628 (2017).
Synthesis of (-)-okundoperoxide and determination of the absolute configuration of natural (+)-okundoperoxide.
N. Mori, D. Sakoda, H. Watanabe, Tetrahedron Lett., 58, 3884-3886 (2017).
2016年
Electochemical asymmetric dimerization of cinnamic acid derivatives and application to the enantioselective syntheses of furofuran lignans.
N. Mori, A. Furuta, H. Watanabe, Tetrahedron, 72, 8393-8399 (2016).
Synthesis of (-)-Chamobtusin A from (+)-Dehydroabietylamine.
N. Mori, K. Kuzuya, H. Watanabe; J. Org. Chem., 81, 11866-11870 (2016).
Stereoselective synthesis of (±)-urechitol A employing [4+3] cycloaddition.
T. Sumiya, K. Ishigami, H. Watanabe; Tetrahedron, 72, 6982-6987 (2016).
2015年
Asymmetric Formal Synthesis of Azadirachtin.
N. Mori, T. Kitahara, K. Mori, H. Watanabe; Angew. Chem. Int. Ed., 54, 14920-14923 (2015).
Synthesis and revision of the relative configuration of glabramycin B.
K. Ishigami, M. Yamamoto, H. Watanabe; Tetrahedron Lett., 56, 6290-6293 (2015).
キラリティーを有する天然生理活性物質の合成研究.
K. Ishigami,T. Kato, S. Wakamori, H. Kageji, H. Watanabe; Annual Report 2014 (Cryogenic Research Center, The University of Tokyo), 6, 39-44 (2015).
Synthesis of marine oxylipin topsentolide A1 and its stereoisomers, and determination of the absolute configuration of the natural product.
K. Ishigami, M. Kobayashi, M. Takagi, K. Shin-ya, H. Watanabe; Tetrahedron, 71, 8436-8443 (2015).
Synthesis of (±)-(Z)-2β-hydroxy-14-hydro-β-santalol employing tandem radical cyclization.
K. Ishigami, S. Yamada, H. Watanabe; Tetrahedron Lett., 56, 5816-5819 (2015).
2012年
Total synthesis of (±)-lysidicin A.
Y. Ogura, K. Ishigami, H. Watanabe; Tetrahedron, 68, 1723-1728 (2012).
2011年
Asymmetric Synthesis and Sensory Evaluation of Sedanenolide .
D. Oguro, H. Watanabe; Biosci. Biotechnol. Biochem., 75, 1502-1505 (2011).
Synthesis and sensory evaluation of all stereoisomers of sedanolide .
D. Oguro, H. Watanabe; Tetrahedron, 67, 777-781 (2011).
Synthesis and anti-migrative evaluation of moverastin derivatives.
M. Sawada, S. Kubo, K. Matsumura, Y. Takemoto, H. Kobayashi, E. Tashiro, T. Kitahara, H. Watanabe, M. Imoto; Bioorg. Med. Chem. Lett., 21, 1385-1389 (2011).
2010年
Determination of the absolute configuration of marine oxylipin topsentolide A1 by the synthesis of the enantiomer of the natural product.
M. Kobayashi, K. Ishigami, H. Watanabe; Tetrahedron Lett., 51, 2762-2764 (2010).
Determination of the absolute configuration of nodulisporacid A by the concise synthesis of four stereoisomers via three-component reaction and one-pot construction of the framework.
T. Sumiya, K. Ishigami, H. Watanabe; Tetrahedron Lett., 51, 2765-2767 (2010).
Stereoselective Total Synthsis of (±)-Urechitol A.
T. Sumiya, K. Ishigami, H. Watanabe; Angew. Chem. Int. Ed., 49, 5527-5528 (2010).
Efficient construction of the core framework of lysidicin A via three Claisen rearrangements including a cascade reaction .
Y. Ogura, H. Watanabe; Tetrahedron Lett., 51, 3294-3296 (2010).
Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.
R. Furumai, K. Uchida, Y. Komi, M. Yoneyama, K. Ishigami, H. Watanabe, S. Kojima, M. Yoshida; Cancer Sci., 101, 2483-2489 (2010).
Synthesis of (2RS,8R,10R)-YM-193221 and an improved approach to tyroscherin, bioactive natural compounds from Pseudallescheria sp.
R. Katsuta, A. Yajima, K. Ishigami, T. Nukada, H. Watanabe; Biosci. Biotechnol. Biochem., 74, 2056-2059 (2010).
Synthesis of (±)-Chamobtusin A by a Presumed Biomimetic Aza-Cyclization.
K. Kuzuya, N. Mori, H. Watanabe; Org. Lett., 12, 4709-4711 (2010).
2009年
Enantioselective synthesis of phomallenic acid C by In- and Pd-mediated anti-SN2' coupling.
T. Kato, K. Ishigami, K. Akasaka, H. Watanabe; Tetrahedron, 65, 6953-6958(2009).
Physically Discrete beta-Lactamase-Type Thioesterase Catalyzes Product Release in Atrochrysone Synthesis by Iterative Type I Polyketide Synthase
T. Awakawa, K. Yokota, N. Funa, F. Doi, N. Mori N, H. Watanabe, S. Horinouchi, Chem. & Biol., 16, 613-623 (2009).
Synthetic Studies of Natural 10-Membered Lactones, Mueggelone, Microcarpalide, and Sch 642305, Which Have Interesting Bioactivities.
K. Ishigami; Biosci. Biotechnol. Biochem., 73, 971-979 (2009).
Synthesis and Structure Revision of Tyroscherin, and Bioactivities of Its Stereoisomers Against IGF-1-Dependent Tumor Cells.
K. Ishigami, R. Katsuta, C. Shibata, Y. Hayakawa, H. Watanabe and T. Kitahara; Tetrahedron, 65, 3629-3638 (2009).
2008年
Synthesis and Structure Revision of Tyroscherin, a Growth Inhibitor of IGF-1-dependent Tumor Cells.
R. Katsuta, C. Shibata, K. Ishigami, H. Watanabe and T. Kitahara; Tetrahedron Lett., 49, 7042-7045 (2008).
Synthesis of FF8181-A.
N. Kobayashi, H. Kuniyoshi, K. Ishigami and H. Watanabe; Biosci. Biotechnol. Biochem., 72, 2708-2715(2008).
Incorporation and remodeling of extracellular phosphatidylcholine with short acyl residues in Saccharomyces cerevisiae.
K. Tanaka, R. Fukuda, Y. Ono, H. Eguchi, S. Nagasawa, Y. Nakatani, H. Watanabe, H. Nakanishi, R. Taguchi and A. Ohta; Biochim. Biophys. Acta., 1781, 391-399 (2008).
Enantioselective Synthesis of Phomallenic Acid C, an Inhibitor of FAS II Pathway.
K. Ishigami, T. Kato, K. Akasaka and H. Watanabe; Tetrahedron Lett., 49, 5077-5079 (2008).
2007年
Inhibition of splicing and nuclear retention of pre-mRNAby spliceostatin A in fission yeast.
C.-W. Lo, D. Kaida, S. Nishimura, A. Matsuyama, Y. Yashiroda, H. Taoka, K. Ishigami, H. Watanabe, H. Nakajima, T. Tani, S. Horinouchi and M. Yoshida; Biochem. Biophys. Res. Commun., 364, 573-577 (2007).
Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator.
Y. Umeda, K. Furihata, S. Sakuda, H. Nagasawa, K. Ishigami, H. Watanabe, M. Izumikawa, M. Takagi, T. Doi, Y. Nakao and K. Shin-ya; Org. Lett., 9, 4239-4242 (2007).
Revision of the stereochemistries of natural products through the synthetic study: synthesis of fudecalone and kaitocephalin.
H. Watanabe and T. Kitahara; Yuki Gosei Kagaku Kyokaishi, 65, 511-519 (2007).
Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
J. Kato, N. Funa, H. Watanabe, Y. Ohnishi and S. Horinouchi; Proc. Natl. Acad. Sci. USA,104, 2378-2383 (2007).
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
D. Kaida, H. Motoyoshi, E. Tashiro, T. Nojima, M. Hagiwara, K. Ishigami, H. Watanabe, T. Kitahara, T. Yoshida, H. Nakajima, T. Tani, S. Horinouchi and M. Yoshida; Nature Chem. Biol., 3, 576-583 (2007).
Synthetic study towards azadirachtin: an efficient and stereoselective construction of the AB rings with full functionality.
H. Watanabe, N. Mori, D. Itoh, T. Kitahara and K. Mori; Angew. Chem. Int. Ed., 46, 1512-1516 (2007).
Synthesis of an Insecticidal Tetrahydroisocoumarin, (3R,4S,4aR)-4,8-Dihydroxy-3-methyl-3,4,4a,5- tetrahydro-1H-2-benzopyran-1-one.
K. Uchida, K. Ishigami, H. Watanabe and T. Kitahara; Tetrahedron, 63, 1281-1287 (2007).
Synthesis of (-)-Mellein, (+)-Ramulosin and Related Natural Products.
Md. S. Islam, K. Ishigami and H. Watanabe; Tetrahedron, 63, 1074-1079 (2007).
2006年
Synthesis of gerfelin and related analogous compounds.
Md. S. Islam, M. Kitagawa, M. Imoto, T. Kitahara and H. Watanabe; Biosci. Biotechnol. Biochem., 70, 2523-2528 (2006).
Simple synthesis of enantiomerically pure sauriols A and B.
N. Mori, H. Watanabe and T. Kitahara; Biosci. Biotechnol. Biochem., 70, 1750-1753 (2006).
Simple and efficient asymmetric synthesis of furofuran lignans yangambin and caruilignan A.
N. Mori, H. Watanabe and T. Kitahara; Synthesis, 400-404 (2006).
Stereoselective Synthesis of Sch 642305, an Inhibitor of Bacterial DNA Primase.
K. Ishigami, R. Katsyta and H. Watanabe; Tetrahedron, 62, 2224-2230 (2006).
Total synthesis of FR901464: second generation.
H. Motoyoshi, M. Horigome, H. Watanabe and T. Kitahara; Tetrahedron, 62, 1378-1389 (2006).
Enantioselective total synthesis of (2R,3R,6R)-N-Methyl-6-(deca-1',3',5'-trienyl)-3-methoxy-2-methylpiperidine, an insecticidal alkaloid.
Y. Nakatani, J. Oshita, K. Ishigami H. Watanabe and T. Kitahara; Tetrahedron, 62, 160-165 (2006).
2005年
Stereoselective Synthesis of Microcarpalide.
K. Ishigami H. Watanabe and T. Kitahara; Tetrahedron, 61, 7546-7553 (2005).
Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger.
Y. Umeda, S. Chijiwa, K. Furihata, K. Furihata, S. Sakuda, H. Nagasawa, H. Watanabe, K. Shin-ya; J. Antibiot., 58, 206-209 (2005).
2004年
An Odorant Derivative as an Antagonist for an Olfactory Receptor.
Y. Oka, A. Nakamura, H. Watanabe and K. Touhara; Chem. Senses, 29, 815-822 (2004).
Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes.
H. Motoyoshi, M. Horigome, K. Ishigami, T. Yoshida, S. Horinouchi, M. Yoshida, H. Watanabe and T. Kitahara; Biosci. Biotechnol. Biochem., 68, 2178-2182 (2004).
Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp.
Y. Hayakawa, T. Yamashita, T. Mori, K. Nagai, K. Shin-Ya, H. Watanabe; J. Antibiot., 57, 634-638 (2004).
Short-step Synthesis of Chenodiol from Stigmasterol.
T. Uekawa, K. Ishigami and T. Kitahara; Biosci. Biotechnol. Biochem., 68, 1332-1337(2004).
Synthesis of Microcarpalide, a Microfilament Disrupting Agent.
K. Ishigami and T. Kitahara; Heterocycles, 63, 785-790 (2004).