He moved to Tokyo University of Agriculture in 2017
[EDUCATION]
1992.3 B.Sc. Department of Agricultural Chemistry
The University of Tokyo (Supervisor: Prof. Kenji Mori)
1992.4-1994.3 Graduate School; Department of Applied Biological Chemistry
The University of Tokyo (Supervisor: Prof. Haruo Seto)
1994.4-1997.3 Graduate School; Department of Applied Biological Chemistry
The University of Tokyo (Supervisor: Prof. Takeshi Kitahara)
1997.3 Ph. D. (Doctor of Agriculture, The University of Tokyo)
[ACADEMIC CAREER]
1996.4-1997.3 JSPS (Japan Society for the Promotion of Science) Fellow
Department of Applied Biological Chemistry
The University of Tokyo (Prof. Takeshi Kitahara)
1997.4-1997.6 JSPS Postdoctoral Fellow
Department of Applied Biological Chemistry
The University of Tokyo (Prof. Takeshi Kitahara)
1997.6-2005.8 Research Associate
Department of Applied Biological Chemistry,
The University of Tokyo (Professor Takeshi Kitahara)
(1997.7-1998.9) Part-time Lecturer, Department of Nutrition and Food Science,
Ochanomizu University
(1999.4-2000.3) Part-time Lecturer, Department of Chemistry,
The Science University of Tokyo
(2000.6-2001.5) Visiting Researcher
Department of Chemistry, University of Pittsburgh
(Prof. Peter Wipf)
2005.8-2008.8 Lecturer
Department of Applied Biological Chemistry,
The University of Tokyo (Professor Hidenori Watanabe)
(2008-) Part-time Lecturer, Yokohama National University
2008.8-present Associate Professor
The University of Tokyo
[RESEARCH FIELD, INTEREST]
(1) Enantioselective Synthesis of Bioactive Natural Products
(2) Biochemical Transformations and Their Use in Organic Synthesis
(3) Clarification of Molecular Mechanism of Action
(3) Isolation and Structure Determination of Natural Products Using NMR, MS Techniques
[AWARD]
Nogeikagaku Award for Young Scientist, 2008
(Japan Society for Bioscience, Biotechnology, and Agrochemistry)
[PUBLICATIONS]
(1) Synthesis of the Enantiomers of Rhynchophorol [(E)-6-Methyl-2-hepten-4-ol], the Male-Produced Aggregation Pheromone of the American Palm Weevil, Rhynchophorus palmarum.
K. Mori and K. Ishigami; Liebigs Ann. Chem., 1992, 1195-1198.
(2) Cororubicin, a New Anthracycline Antibiotic Generating Active Oxygen in Tumor Cells.
K. Ishigami, Y. Hayakawa and H. Seto; J. Antibiotics, 47, 1219-1225 (1994).
(3) Menoxymycins A and B, Antitumor Antibiotics Generating Active Oxygen in Tumor Cells.
Y. Hayakawa, K. Ishigami, K. Shin-ya and H. Seto; J. Antibiotics, 47, 1344-1347 (1994).
(4) Synthesis of All the Four Possible Stereoisomers of Acaterin, Naturally Occurring ACAT Inhibitor, and the Determination of Its Absolute Configulation.
K. Ishigami and T. Kitahara; Tetrahedron, 51, 6431-6442 (1995).
(5) Synthetic Studies on Antitumor Antibiotics and Enzyme Inhibitors.
T. Kitahara, T. Hasegawa, K. Ishigami and Y. Kinoshita; New Trends in Natural Product Chemistry, Atta-ur-Rahman ed., Harwood Academic Publishers, Switzerland, 39-45 (1997).
(6) Synthesis of Solamin.
W. Kuriyama, K. Ishigami and T. Kitahara; Heterocycles, 50, 981-988 (1999).
(7) First Total Synthesis of Mueggelone.
K. Ishigami, H. Motoyoshi and T. Kitahara; Tetrahedron Lett., 41, 8897-8901 (2000) .
(8) Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase.
S.-W. Ki, K. Ishigami , T. Kitahara, K. Kasahara, M. Yoshida and S. Horinouchi; J. Biol. Chem, 275, 39231-39236 (2000).
(9) First Total Synthesis and Determination of the Absolute Configuration of Mueggelone.
H. Motoyoshi, K. Ishigami and T. Kitahara; Tetrahedron, 57, 3899-3908 (2001).
(10) Radicicol Binds Swo/Hsp90 and Inhibits Growth of Specific Temperature-Sensitive Cell Cycle Mutants of Fission Yeast.
S. W. Ki, K. Kasahara, H. J. Kwon, K. Ishigami , T. Kitahara, T. Beppu, M. Yoshida and S. Horinouchi; Biosci. Biotechnol. Biochem, 65, 2528-2534 (2001).
(11) Synthesis and Biological Evaluation of Analogs of the Tetrahedropyran Acetogenin, Muconin.
W.-Q. Yang, K. Ishigami and T. Kitahara; Proc. Japan. Acad., 77, Ser. B, 157-160 (2001).
(12) 学会見聞記−2002年度日本農芸化学会大会１.
K. Ishigami; バイオサイエンスとインダストリー, 60, 394-395 (2002).
(13) ものつくりが目指すバイオサイエンス.
H. Watanabe, K. Ishigami and T. Kitahara; 化学と生物, 41, 533-540 (2002).
(14) Synthesis of Both Enantiomers of Brevioxime and Determination of Its Absolute Configulation. Y. Nishimura, K. Ishigami and T. Kitahara; Heterocycles, 61, 481-491 (2003).
(15) Synthesis of Microcarpalide, a Microfilament Disrupting Agent.
K. Ishigami and T. Kitahara; Heterocycles, 63, 785-790 (2004).
(16) Short-step Synthesis of Chenodiol from Stigmasterol.
T. Uekawa, K. Ishigami and T. Kitahara; Biosci. Biotechnol. Biochem., 68, 1332-1337 (2004).
(17) Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes.
H. Motoyoshi, M. Horigome, K. Ishigami, T. Yoshida, S. Horinouchi, M. Yoshida, H. Watanabe and T. Kitahara; Biosci. Biotechnol. Biochem., 68, 2178-2182 (2004).
(18) Stereoselective Synthesis of Microcarpalide.
K. Ishigami H. Watanabe and T. Kitahara; Tetrahedron, 61, 7546-7553 (2005).
(19) Enantioselective total synthesis of (2R,3R,6R)-N-Methyl-6-(deca-1',3',5'-trienyl)-3-methoxy-2-methylpiperidine, an insecticidal alkaloid.
Y. Nakatani, J. Oshita, K. Ishigami H. Watanabe and T. Kitahara; Tetrahedron, 62, 160-165 (2006).
(20) Stereoselective Synthesis of Sch 642305, an Inhibitor of Bacterial DNA Primase.
K. Ishigami, R. Katsyta and H. Watanabe; Tetrahedron, 62, 2224-2230 (2006).
(21) 学会見聞記−2006年度日本農芸化学会大会１.
K. Ishigami; バイオサイエンスとインダストリー, 64, 336-337 (2006).
(22) Synthesis of (-)-Mellein, (+)-Ramulosin and Related Natural Products.
Md. S. Islam, K. Ishigami and H. Watanabe; Tetrahedron, 63, 1074-1079 (2007).
(23) Synthesis of an Insecticidal Tetrahydroisocoumarin, (3R,4S,4aR)-4,8-Dihydroxy-3-methyl-3,4,4a,5- tetrahydro-1H-2-benzopyran-1-one.
K. Uchida, K. Ishigami, H. Watanabe and T. Kitahara; Tetrahedron, 63, 1281-1287 (2007).
(24) Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
D. Kaida, H. Motoyoshi, E. Tashiro, T. Nojima, M. Hagiwara, K. Ishigami, H. Watanabe, T. Kitahara, T. Yoshida, H. Nakajima, T. Tani, S. Horinouchi and M. Yoshida; Nature Chem. Biol., 3, 576-583 (2007).
(25) Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator.
Y. Umeda, K. Furihata, S. Sakuda, H. Nagasawa, K. Ishigami, H. Watanabe, M. Izumikawa, M. Takagi, T. Doi, Y. Nakao and K. Shin-ya; Org. Lett., 9, 4239-4242 (2007).
(26) Inhibition of splicing and nuclear retention of pre-mRNAby spliceostatin A in fission yeast.
C.-W. Lo, D. Kaida, S. Nishimura, A. Matsuyama, Y. Yashiroda, H. Taoka, K. Ishigami, H. Watanabe, H. Nakajima, T. Tani, S. Horinouchi, M. Yoshida; Biochem. Biophys. Res. Commun., 364, 573-577 (2007).
(27) 学会見聞記−日本農芸化学会.
K. Ishigami; バイオサイエンスとインダストリー, 66, 303-304 (2008).
(28) Enantioselective Synthesis of Phomallenic Acid C, an Inhibitor of FAS II Pathway.
K. Ishigami, T. Kato, K. Akasaka, and H. Watanabe; Tetrahedron Lett., 49, 5077-5079 (2008).
(29) Synthesis of FF8181-A.
N. Kobayashi, H. Kuniyoshi, K. Ishigami and H. Watanabe; Biosci. Biotechnol. Biochem., 72, 2708-2715(2008).
(30) 注目の論文 「狙ったC-H結合を酸化する」.
K. Ishigami; 化学, 63 (10), 66-67 (2008).
(31) Synthesis and Structure Revision of Tyroscherin, a Growth Inhibitor of IGF-1-dependent Tumor Cells.
R. Katsuta, C. Shibata, K. Ishigami, H. Watanabe, T. Kitahara; Tetrahedron Lett., 49, 7042-7045 (2008).
(32) Synthesis and Structure Revision of Tyroscherin, and Bioactivities of Its Stereoisomers Against IGF-1-Dependent Tumor Cells.
K. Ishigami, R. Katsuta, C. Shibata, Y. Hayakawa, H. Watanabe, T. Kitahara; Tetrahedron, 65, 3629-3638 (2009).
(33) Synthetic Studies of Natural 10-Membered Lactones, Mueggelone, Microcarpalide, and Sch 642305, Which Have Interesting Bioactivities.
K. Ishigami; Biosci. Biotechnol. Biochem., 73, 971-979 (2009).
(34) Enantioselective synthesis of phomallenic acid C by In- and Pd-mediated anti-SN2' coupling.
T. Kato, K. Ishigami, K. Akasaka, H. Watanabe; Tetrahedron, 65, 6953-6958(2009).
(35) (+)-Sch642305.
K. Ishigami, H. Watanabe, Total Synthesis of Natural Products 2000〜2008 (Japan), The Society of Synthetic Organic Chemistry Japan ed., Kagakudojin, Japan (2009).
(36) Determination of the absolute configuration of marine oxylipin topsentolide A1 by the synthesis of the enantiomer of the natural product.
M. Kobayashi, K. Ishigami, H. Watanabe; Tetrahedron Lett., 51, 2762-2764 (2010).
(37) Determination of the absolute configuration of nodulisporacid A by the concise synthesis of four stereoisomers via three-component reaction and one-pot construction of the framework.
T. Sumiya, K. Ishigami, H. Watanabe; Tetrahedron Lett., 51, 2765-2767 (2010).
(38) Stereoselective Total Synthsis of (±)-Urechitol A.
T. Sumiya, K. Ishigami, H. Watanabe; Angew. Chem. Int. Ed., 49, 5527-5528 (2010).
(39) Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.
R. Furumai, K. Uchida, Y. Komi, M. Yoneyama, K. Ishigami, H. Watanabe, S. Kojima, M. Yoshida; Cancer Sci., 101, 2483-2489 (2010).
(40) Synthesis of (2RS,8R,10R)-YM-193221 and an improved approach to tyroscherin, bioactive natural compounds from Pseudallescheria sp.
R. Katsuta, A. Yajima, K. Ishigami, T. Nukada, H. Watanabe; Biosci. Biotechnol. Biochem., 74, 2056-2059 (2010).
(41) フラン環の開裂およびDieckmann縮合.
K. Ishigami, H. Watanabe, 天然物合成で活躍した反応−実験のコツとポイント, The Society of Synthetic Organic Chemistry Japan ed., Kagakudojin, Japan (2011).
(42) 天然物化学における有機合成.
K. Ishigami; Annual Report 2010 (Cryogenic Research Center, The University of Tokyo), 2, 32-38 (2011).
(43) Total synthesis of (±)-lysidicin A.
Y. Ogura, K. Ishigami, H. Watanabe; Tetrahedron, 68, 1723-1728 (2012).
(44) 最新のトピックス 「フローケミストリーでマラリアを克服!?」.
K. Ishigami, H. Watanabe; 化学, 67, 68-69 (2012).
(45) 低分子有機化合物取扱い法・有機化合物の合成.
K. Ishigami N. Mori; 21世紀のバイオサイエンス 実験農芸化学, 東京大学大学院農学生命科学研究科応用生命化学専攻応用生命工学専攻編, 朝倉書店 (2013).
(46) Synthesis of (±)-(Z)-2β-hydroxy-14-hydro-β-santalol employing tandem radical cyclization.
K. Ishigami, S. Yamada, H. Watanabe; Tetrahedron Lett., 56, 5816-5819 (2015).
(47) Synthesis of marine oxylipin topsentolide A1 and its stereoisomers, and determination of the absolute configuration of the natural product.
K. Ishigami, M. Kobayashi, M. Takagi, K. Shin-ya, H. Watanabe; Tetrahedron, 71, 8436-8443 (2015).
(48) Synthesis and revision of the relative configuration of glabramycin B.
K. Ishigami, M. Yamamoto, H. Watanabe; Tetrahedron Lett., 56, 6290-6293 (2015).
(49) キラリティーを有する天然生理活性物質の合成研究.
K. Ishigami,T. Kato, S. Wakamori, H. Kageji, H. Watanabe; Annual Report 2014 (Cryogenic Research Center, The University of Tokyo), 6, 39-44 (2015).
(50) Stereoselective synthesis of (±)-urechitol A employing [4+3] cycloaddition.
T. Sumiya, K. Ishigami, H. Watanabe; Tetrahedron, 72, 6982-6987 (2016).