BLASTP 2.0.14 [Jun-29-2000]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

RID: 963285604-15209-14012

Query= T21E3.1 CE13874    (ST.LOUIS) TR:O01767
protein_id:AAB54136.1
         (753 letters)


Database: nr
           517,904 sequences; 162,524,432 total letters

 
If you have any problems or questions with the results of this search 
please refer to the BLAST FAQs


Taxonomy reports



                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||T29763  hypothetical protein T21E3.1 - Caenorhabditis e...  1497  0.0
pir||T33093  hypothetical protein R12E2.10 - Caenorhabditis ...  1487  0.0
pir||T22184  hypothetical protein F44F4.2 - Caenorhabditis e...   131  2e-29
pir||T25917  hypothetical protein T27A3.5 - Caenorhabditis e...   115  2e-24
pir||T29154  hypothetical protein F47B3.7 - Caenorhabditis e...   110  4e-23
pir||T19121  probable protein-tyrosine-phosphatase (EC 3.1.3...   106  8e-22
emb|CAA86842.2|  (Z46811) similar to protein-tyrosine phosph...   106  8e-22
ref|NP_002824.1|  protein tyrosine phosphatase, non-receptor...   106  8e-22
gb|AAF46513.1|  (AE003447) CG3101 gene product [Drosophila m...   105  1e-21
gb|AAC02582.1|  (AF045642) Contains similarity to Pfam domai...   105  2e-21
gb|AAB66898.1|  (AF013490) protein-tyrosine phosphatase; PTP...   104  2e-21
pir||T29156  hypothetical protein F47B3.1 - Caenorhabditis e...   101  2e-20
pir||T29153  hypothetical protein F47B3.6 - Caenorhabditis e...   101  2e-20
pir||T33446  hypothetical protein F36H12.10 - Caenorhabditis...   100  8e-20
gb|AAF49892.1|  (AE003540) Ptp69D gene product [Drosophila m...    99  1e-19
ref|NP_006495.1|  protein tyrosine phosphatase, receptor typ...    99  1e-19
pir||T20729  hypothetical protein F10G8.1 - Caenorhabditis e...    98  3e-19
sp|P16620|PTP6_DROME  PROTEIN-TYROSINE PHOSPHATASE DPTP PREC...    98  3e-19
ref|NP_002823.1|  protein tyrosine phosphatase, non-receptor...    97  5e-19
sp|P35236|PTN7_HUMAN  PROTEIN-TYROSINE PHOSPHATASE LC-PTP (H...    97  5e-19
gb|AAC52281.1|  (U35368) epsilon tyrosine phosphatase [Mus m...    97  7e-19
gb|AAC52331.1|  (U36758) epsilon tyrosine phosphatase cytopl...    97  7e-19
ref|NP_035342.1|  protein tyrosine phosphatase, receptor typ...    97  7e-19
dbj|BAA11927.1|  (D83484) protein tyrosine phosphatase epsil...    97  7e-19
pir||JC6132  protein-tyrosine-phosphatase (EC 3.1.3.48) - mo...    97  7e-19
ref|NP_031981.1|  embryonic stem cell phosphatase >gi|318313...    97  7e-19
dbj|BAA20333.1|  (D78610) protein tyrosine phosphatase epsil...    96  9e-19
pir||T32543  hypothetical protein M04G7.2 - Caenorhabditis e...    96  9e-19
dbj|BAA05886.1|  (D28530) protein tyrosine phosphatase PTPT9...    95  2e-18
gb|AAF60945.1|  (AC006833) contains similarity to TR:O95063 ...    95  2e-18
pir||T23308  hypothetical protein K04D7.4 - Caenorhabditis e...    94  4e-18
gb|AAB22439.1|  (S39392) protein tyrosine phosphatase, PTPas...    94  4e-18
ref|NP_002820.1|  protein tyrosine phosphatase, non-receptor...    94  4e-18
gb|AAA50568.1|  (L19181) receptor-linked protein tyrosine ph...    94  5e-18
pir||S46217  protein-tyrosine-phosphatase (EC 3.1.3.48) type...    94  5e-18
pir||A48758  protein-tyrosine-phosphatase (EC 3.1.3.48), rec...    94  5e-18
pir||I58148  protein-tyrosine-phosphatase (EC 3.1.3.48) - bl...    94  5e-18
sp|P49445|PTN7_RAT  PROTEIN-TYROSINE PHOSPHATASE LC-PTP (HEM...    94  5e-18
pir||B48758  protein-tyrosine-phosphatase (EC 3.1.3.48), rec...    94  5e-18
gb|AAA75407.1|  (L19180) receptor-linked protein tyrosine ph...    94  5e-18
gb|AAC37656.1|  (L11587) leukocyte common antigen-related ph...    94  5e-18
gb|AAB28877.1|  receptor protein tyrosine phosphatase-sigma,...    94  5e-18
gb|AAF56891.1|  (AE003769) CG2005 gene product [Drosophila m...    94  6e-18
gb|AAA28486.1|  (M80464) protein-tyrosine phosphatase [Droso...    94  6e-18
sp|P35832|PTP9_DROME  PROTEIN-TYROSINE PHOSPHATASE 99A PRECU...    94  6e-18
gb|AAA28485.1|  (M80539) receptor-linked protein tyrosine ph...    94  6e-18
pir||T21913  hypothetical protein F44G4.8 - Caenorhabditis e...    93  1e-17
pir||JH0609  protein-tyrosine-phosphatase (EC 3.1.3.48) P19 ...    92  1e-17
sp|Q64612|PTPO_RAT  OSTEOTESTICULAR PROTEIN TYROSINE PHOSPHA...    92  1e-17
pir||A55148  protein-tyrosine-phosphatase (EC 3.1.3.48), rec...    92  1e-17

Alignments
>pir||T29763 hypothetical protein T21E3.1 - Caenorhabditis elegans
 gb|AAB54136.1| (AF003133) contains similarity to the catalytic domain of
           protein-tyrosine phosphatases [Caenorhabditis elegans]
          Length = 753

 Score = 1497 bits (3834), Expect = 0.0
 Identities = 737/753 (97%), Positives = 737/753 (97%)

Query: 1   MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGXXXXXXXXXXXXXXXXVDYPQQKGVS 60
           MALNSEVMFREQINAMRSQAGRKRATSLQSFCSG                VDYPQQKGVS
Sbjct: 1   MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGNTDDSSADSTDNMDMMVDYPQQKGVS 60

Query: 61  CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR 120
           CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR
Sbjct: 61  CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR 120

Query: 121 KSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTR 180
           KSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTR
Sbjct: 121 KSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTR 180

Query: 181 KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD 240
           KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD
Sbjct: 181 KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD 240

Query: 241 TEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST 300
           TEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST
Sbjct: 241 TEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST 300

Query: 301 FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKR 360
           FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKR
Sbjct: 301 FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKR 360

Query: 361 VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN 420
           VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN
Sbjct: 361 VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN 420

Query: 421 HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT 480
           HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT
Sbjct: 421 HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT 480

Query: 481 QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG 540
           QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG
Sbjct: 481 QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG 540

Query: 541 VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD 600
           VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD
Sbjct: 541 VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD 600

Query: 601 HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF 660
           HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF
Sbjct: 601 HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF 660

Query: 661 FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP 720
           FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP
Sbjct: 661 FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP 720

Query: 721 NYRREAPDCVGEMPNKVATVDGILSPAKSVFEF 753
           NYRREAPDCVGEMPNKVATVDGILSPAKSVFEF
Sbjct: 721 NYRREAPDCVGEMPNKVATVDGILSPAKSVFEF 753



>pir||T33093 hypothetical protein R12E2.10 - Caenorhabditis elegans
 gb|AAC17031.1| (AF067219) contains similarity to protein-tyrosine phosphatase
           domains (Pfam; Y_phosphatase, score; 130.89)
           [Caenorhabditis elegans]
          Length = 753

 Score = 1487 bits (3808), Expect = 0.0
 Identities = 731/753 (97%), Positives = 735/753 (97%)

Query: 1   MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGXXXXXXXXXXXXXXXXVDYPQQKGVS 60
           MALNSEVMFREQINAMRSQAGRKRATSLQSFCSG                VDYPQQKGVS
Sbjct: 1   MALNSEVMFREQINAMRSQAGRKRATSLQSFCSGNTDDSSADSTDNMDMMVDYPQQKGVS 60

Query: 61  CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR 120
           CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR
Sbjct: 61  CMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPRGAPSTYAAPSKLR 120

Query: 121 KSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAARTAMQVEPALVMKTR 180
           KSKALDCLVSEKPKDEGR EDSGHGADIEMAKGHFN+VRMKVFAARTAMQVEPALVMKTR
Sbjct: 121 KSKALDCLVSEKPKDEGRSEDSGHGADIEMAKGHFNDVRMKVFAARTAMQVEPALVMKTR 180

Query: 181 KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD 240
           KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD
Sbjct: 181 KALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKKVTKEAMANLIRSSYDD 240

Query: 241 TEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST 300
           TEITQELLFSSKFD+KWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST
Sbjct: 241 TEITQELLFSSKFDSKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLKSICEKFGINST 300

Query: 301 FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETMAEYLLRELDASTMQKR 360
           FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNET+AEYLLRELDASTMQKR
Sbjct: 301 FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNETLAEYLLRELDASTMQKR 360

Query: 361 VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN 420
           VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN
Sbjct: 361 VQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGGMERRFEILENSVN 420

Query: 421 HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT 480
           HIPFTHSASDNNQEKCRNPRVHC+DSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT
Sbjct: 421 HIPFTHSASDNNQEKCRNPRVHCRDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMT 480

Query: 481 QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG 540
           QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG
Sbjct: 481 QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFG 540

Query: 541 VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD 600
           VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD
Sbjct: 541 VYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHD 600

Query: 601 HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF 660
           HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF
Sbjct: 601 HLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF 660

Query: 661 FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP 720
           FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP
Sbjct: 661 FFRDVIGSAKELDVDYERWLQERSERMFLDDLAAPIPGYRLLSPRADPDIVRMVGRPERP 720

Query: 721 NYRREAPDCVGEMPNKVATVDGILSPAKSVFEF 753
           NYRREAPDCVGEMPNKVA VDGILSPAKSVFEF
Sbjct: 721 NYRREAPDCVGEMPNKVAAVDGILSPAKSVFEF 753



>pir||T22184 hypothetical protein F44F4.2 - Caenorhabditis elegans
 emb|CAA85453.1| (Z37092) similar to Protein-tyrosine phosphatase~cDNA EST
           EMBL:Z14815 comes from this gene~cDNA EST EMBL:Z14828
           comes from this gene~cDNA EST EMBL:M89181 comes from
           this gene~cDNA EST EMBL:D67489 comes from this gene~cDNA
           EST EMBL:D74781 comes from thi>
          Length = 555

 Score =  131 bits (327), Expect = 2e-29
 Identities = 76/218 (34%), Positives = 117/218 (52%), Gaps = 22/218 (10%)

Query: 461 DFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP-------- 512
           DFIHAN + G PL N FI  QAP+KNT +DFWRMV+QE+  +IVML S  +         
Sbjct: 296 DFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLGPLDS 355

Query: 513 ---ERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRL--IGPD------R 561
                C YYWP++ ++      G   I    V    DPLF +T L++  +G +       
Sbjct: 356 ANRNHCPYYWPRAENESLRF--GSFHITCMKVDSKADPLFTITKLKVQKVGGNLLDAEFD 413

Query: 562 EERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLL 621
           EE  +EHWQ D     +++ P  +LR  R  S P ++    G S++  LV+ E A+   +
Sbjct: 414 EELFLEHWQWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFI 473

Query: 622 RG-PTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV 658
           RG P  K  + ++  F+R +R  S+ + + Y+F++R++
Sbjct: 474 RGSPITKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVI 511



>pir||T25917 hypothetical protein T27A3.5 - Caenorhabditis elegans
 gb|AAB42298.1| (U88180) contains similarity to protein-tyrosine phosphatase
           domains PS:PS00383 [Caenorhabditis elegans]
          Length = 365

 Score =  115 bits (285), Expect = 2e-24
 Identities = 68/222 (30%), Positives = 116/222 (51%), Gaps = 14/222 (6%)

Query: 441 VHCKDSTRIALQFPRGQYLGDFIHAN--RISGKPLFNEFIMTQAPMKNTVDDFWRMVWQE 498
           V+C D TR+ L++P      D+IHAN  +I+G    N+FI TQ P + TVDDF+R++WQE
Sbjct: 124 VYCIDDTRVVLKWPEDSP-SDYIHANWVKINGA---NKFICTQGPTEKTVDDFYRLIWQE 179

Query: 499 EVPYIVMLTSRKE--PERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRL 556
           + P +VML +  E   ++CE YWP++     + + G L ++     +  +    +  + +
Sbjct: 180 KAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNILLMKITV 239

Query: 557 IGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIA 616
           I       + EHWQ        +      L +    + P+V+H   G+ R   +V  EIA
Sbjct: 240 IDDKGTSHNFEHWQWKAWPDRGVPE----LPMALKTASPIVVHCSAGIGRTGSIVGLEIA 295

Query: 617 ICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV 658
           +     G   K  ++  V+ +R +R  S++T  QY+F+HR++
Sbjct: 296 LVKFCAGE--KVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVL 335



>pir||T29154 hypothetical protein F47B3.7 - Caenorhabditis elegans
 gb|AAB52362.1| (U97017) contains similarity to a protein-tyrosine phosphatase gene
           [Caenorhabditis elegans]
          Length = 374

 Score =  110 bits (273), Expect = 4e-23
 Identities = 82/295 (27%), Positives = 137/295 (45%), Gaps = 23/295 (7%)

Query: 405 IGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIH 464
           +  +   F  + N   ++P    A  +N EK R   + C + TR+ L         D+IH
Sbjct: 65  VSKLRDEFSEVANKNPNVPV--DAFKSNPEKNRYTDIKCIEKTRVILTTDGAS--SDYIH 120

Query: 465 ANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKS 522
           AN +       +FI TQ P  +T+ DFW MV Q+ V  I+ML    E  R  CE YWP  
Sbjct: 121 ANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAV 180

Query: 523 PSDPAVTVPGG--LRIENFGV--YQAPDPLFRVTHLRLI--GPDREERHVE--HWQGDVN 574
                  V  G  + I N GV      D    VT+L L+  G  R   H +  +W     
Sbjct: 181 EGQTNTYVSKGHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGA 240

Query: 575 NSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAV 634
              NM   +N++  +   + PVV+H   GV R+  +V   + +  +++G   K  +++ V
Sbjct: 241 PPINM-GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCK-DMKKLV 298

Query: 635 QFLRQRRPFSIETPMQYIFVHRLVAFFFRDV-------IGSAKELDVDYERWLQE 682
           + +R +R ++I+T  QY+++HR++  +F ++       +   K  +  Y +WL +
Sbjct: 299 EEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTKNYEEKYAKWLDD 353



>pir||T19121 probable protein-tyrosine-phosphatase (EC 3.1.3.48), receptor C09D8.1
            - Caenorhabditis elegans
          Length = 1585

 Score =  106 bits (262), Expect = 8e-22
 Identities = 74/265 (27%), Positives = 122/265 (45%), Gaps = 24/265 (9%)

Query: 407  GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHAN 466
            G +  FE +E    H  + HS++D N+ K R   V   D +R+ L    G    D+I+AN
Sbjct: 1031 GFQSEFESIETG-QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINAN 1089

Query: 467  RISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPK--- 521
             + G      +I TQ P+  T  DFWRMVW+E+   IVMLT+ +E  R  C+ YWP    
Sbjct: 1090 YVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGT 1149

Query: 522  -SPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPD--REERHVEHWQGDVNNSSN 578
             +  D  VT+   + + ++          R   L+++G    RE +H+++     +   +
Sbjct: 1150 ATYGDIEVTLLESVHLAHY--------TMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPD 1201

Query: 579  MYSPL-----NILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRA 633
              +P       +  L  N + P++ H   G+ R    +  +  +  L    T    +   
Sbjct: 1202 HPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNT--VDIYGC 1259

Query: 634  VQFLRQRRPFSIETPMQYIFVHRLV 658
            V  LR +R + ++T  QYIF+H  V
Sbjct: 1260 VTALRAQRSYMVQTEEQYIFIHDAV 1284



 Score = 71.4 bits (172), Expect = 3e-11
 Identities = 66/224 (29%), Positives = 94/224 (41%), Gaps = 21/224 (9%)

Query: 445  DSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV 504
            DS R+ ++   G    D+I+A+ I G      +I TQAP   T  DFWR +W+   P I 
Sbjct: 1356 DSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIA 1415

Query: 505  ML--TSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDRE 562
            ML  T+ +  E+C  YW   P +  V V G L +E    Y       R   +  I   RE
Sbjct: 1416 MLVRTNERGQEQCSDYW---PLETGVQV-GMLVVEPMAEYDMKHYHLREFRISDIN-TRE 1470

Query: 563  ER-----HVEHWQGDVNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAACLV 611
             R     H   W  DV         L+ +  + N       + P+ +H   G  R A  +
Sbjct: 1471 VRTVRQFHFMEWP-DVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFI 1529

Query: 612  AAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVH 655
            A  I I   +R   +   V   V+ LR  R   I+ P QY F++
Sbjct: 1530 ALSI-ILDRMRA-EHVVDVFTTVKLLRTERQNMIQEPEQYHFLY 1571



>emb|CAA86842.2| (Z46811) similar to protein-tyrosine phosphatase with fibronectin
            type III-like domains (DPTP and LAR like); cDNA EST
            EMBL:D28037 comes from this gene; cDNA EST EMBL:D28036
            comes from this gene; cDNA EST EMBL:D36230 comes from
            this gene; cDNA EST EMBL:>
 emb|CAA90189.2| (Z49938) similar to protein-tyrosine phosphatase with fibronectin
            type III-like domains (DPTP and LAR like)~cDNA EST
            EMBL:D28037 comes from this gene~cDNA EST EMBL:D28036
            comes from this gene~cDNA EST EMBL:D36230 comes from this
            gene~cDNA EST EMBL:D352>
          Length = 2234

 Score =  106 bits (262), Expect = 8e-22
 Identities = 74/265 (27%), Positives = 122/265 (45%), Gaps = 24/265 (9%)

Query: 407  GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHAN 466
            G +  FE +E    H  + HS++D N+ K R   V   D +R+ L    G    D+I+AN
Sbjct: 1680 GFQSEFESIETG-QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINAN 1738

Query: 467  RISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPK--- 521
             + G      +I TQ P+  T  DFWRMVW+E+   IVMLT+ +E  R  C+ YWP    
Sbjct: 1739 YVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGT 1798

Query: 522  -SPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPD--REERHVEHWQGDVNNSSN 578
             +  D  VT+   + + ++          R   L+++G    RE +H+++     +   +
Sbjct: 1799 ATYGDIEVTLLESVHLAHY--------TMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPD 1850

Query: 579  MYSPL-----NILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRA 633
              +P       +  L  N + P++ H   G+ R    +  +  +  L    T    +   
Sbjct: 1851 HPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNT--VDIYGC 1908

Query: 634  VQFLRQRRPFSIETPMQYIFVHRLV 658
            V  LR +R + ++T  QYIF+H  V
Sbjct: 1909 VTALRAQRSYMVQTEEQYIFIHDAV 1933



 Score = 71.4 bits (172), Expect = 3e-11
 Identities = 66/224 (29%), Positives = 94/224 (41%), Gaps = 21/224 (9%)

Query: 445  DSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV 504
            DS R+ ++   G    D+I+A+ I G      +I TQAP   T  DFWR +W+   P I 
Sbjct: 2005 DSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIA 2064

Query: 505  ML--TSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDRE 562
            ML  T+ +  E+C  YW   P +  V V G L +E    Y       R   +  I   RE
Sbjct: 2065 MLVRTNERGQEQCSDYW---PLETGVQV-GMLVVEPMAEYDMKHYHLREFRISDIN-TRE 2119

Query: 563  ER-----HVEHWQGDVNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAACLV 611
             R     H   W  DV         L+ +  + N       + P+ +H   G  R A  +
Sbjct: 2120 VRTVRQFHFMEWP-DVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFI 2178

Query: 612  AAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVH 655
            A  I I   +R   +   V   V+ LR  R   I+ P QY F++
Sbjct: 2179 ALSI-ILDRMRA-EHVVDVFTTVKLLRTERQNMIQEPEQYHFLY 2220



>ref|NP_002824.1| protein tyrosine phosphatase, non-receptor type 9
 sp|P43378|PTN9_HUMAN PROTEIN-TYROSINE PHOSPHATASE MEG2 (PTPASE-MEG2)
 pir||A42690 protein-tyrosine-phosphatase (EC 3.1.3.48), nonreceptor type 9 -
           human
 gb|AAA60226.1| (M83738) protein-tyrosine phosphatase [Homo sapiens]
          Length = 593

 Score =  106 bits (262), Expect = 8e-22
 Identities = 83/262 (31%), Positives = 122/262 (45%), Gaps = 30/262 (11%)

Query: 424 FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAP 483
           F  S S  N EK R   V C D TR+ L    G    D+I+A+ + G    N +I TQ P
Sbjct: 319 FHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGP 378

Query: 484 MKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPSDPAVTVPGGLRIENFGV 541
           ++NT  DFW MVW+++V  IVM T  +E  R  C  YWP    D  +   G L + N GV
Sbjct: 379 LENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE-KDSRIRF-GFLTVTNLGV 436

Query: 542 YQAPDPLFRVTHLRLIG-PDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNASK-- 594
                  ++ T L +    +R++R V H+Q     D    S+  S ++ LR++RN     
Sbjct: 437 ENMNH--YKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLA 494

Query: 595 ---------------PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQ 639
                          P+V+H   G+ R     + +I +  L    T    V + V  +R 
Sbjct: 495 VSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLN--VFQTVSRMRT 552

Query: 640 RRPFSIETPMQYIFVHRLVAFF 661
           +R FSI+TP QY F ++ +  F
Sbjct: 553 QRAFSIQTPEQYYFCYKAILEF 574



>gb|AAF46513.1| (AE003447) CG3101 gene product [Drosophila melanogaster]
          Length = 578

 Score =  105 bits (260), Expect = 1e-21
 Identities = 78/272 (28%), Positives = 116/272 (41%), Gaps = 28/272 (10%)

Query: 407 GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHAN 466
           G+ + +  + N      F H+    N  K R   V C D +R+ L    G    D+I+AN
Sbjct: 283 GLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINAN 342

Query: 467 RISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPS 524
            + G    N +I TQ P+  T  DFWRM+W++    IVM T   E  R  C  YW   P+
Sbjct: 343 FVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYW--EPT 400

Query: 525 DPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQ----GDVNNSSNMY 580
           + +    G   +    V    D +     LR I  D E R+V HWQ     D    S+  
Sbjct: 401 EESSLEFGDYHVRTISVECNEDYMVASLELRNIKTD-EIRNVSHWQFTSWPDYGVPSSAM 459

Query: 581 SPLNILRLLRN-----------------ASKPVVIHDHLGVSRAACLVAAEIAICSLLRG 623
           + LN L+ +R                     P+V+H   G+ R    +  +I I  L   
Sbjct: 460 AMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDV 519

Query: 624 PTYKYPVQRAVQFLRQRRPFSIETPMQYIFVH 655
            T    ++  V+ +R +R +SI+ P QY+F H
Sbjct: 520 GT--ADIRGTVEKIRSQRAYSIQMPDQYVFCH 549



>gb|AAC02582.1| (AF045642) Contains similarity to Pfam domain: PF00102
           (Y_phosphatase), Score=240.3, E-value=8.5e-69, N=1
           [Caenorhabditis elegans]
          Length = 374

 Score =  105 bits (259), Expect = 2e-21
 Identities = 78/262 (29%), Positives = 134/262 (50%), Gaps = 20/262 (7%)

Query: 411 RFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISG 470
           R ++ +N+ N     + +++ N+ K R   V C+D   + +  P      D++HAN + G
Sbjct: 90  RPDMTQNAFN----ANQSANINETKNRYADVPCQDQNIVLVAKPPAP--SDYVHANFV-G 142

Query: 471 KPLFNE--FIMTQAPMKNTVDDFWRMVWQEEVPYIVML--TSRKEPERCEYYWPKSPSDP 526
            P+  +  FI TQ P+ +TVDDFW M+ Q++V  IVML  T      +C  YWP +  + 
Sbjct: 143 CPMVPDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKCAQYWPLAMGEK 202

Query: 527 AVTVPGGLRIENFGVYQA--PDPLFRVTHLRLIGPDRE--ERHVEHWQG--DVNNSSNMY 580
              V GG+ +EN    +    D   ++T L++   D++   RH+ HW    D        
Sbjct: 203 K-EVKGGIVVENVSGTKPMDRDAEIQITTLQVSFGDQKMSVRHL-HWSDWPDRGVPPCKL 260

Query: 581 SPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQR 640
           + L +L  +R +  P+V+H   G+ R   +VA E  +  +        P+   V+ LR +
Sbjct: 261 TSLELLSAVRGSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCP-PMPDLVKSLRDQ 319

Query: 641 RPFSIETPMQYIFVHRLVAFFF 662
           R +SI+T MQY+++HR++  +F
Sbjct: 320 RAYSIQTDMQYLYIHRVMLNYF 341




  Database: nr
    Posted date:  Jul 9, 2000 11:06 PM
  Number of letters in database: 162,524,432
  Number of sequences in database:  517,904
  
Lambda     K      H
   0.320    0.134    0.396 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 232350267
Number of Sequences: 517904
Number of extensions: 9828350
Number of successful extensions: 24442
Number of sequences better than 10.0: 478
Number of HSP's better than 10.0 without gapping: 421
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 23239
Number of HSP's gapped (non-prelim): 756
length of query: 753
length of database: 162,524,432
effective HSP length: 58
effective length of query: 695
effective length of database: 132,486,000
effective search space: 92077770000
effective search space used: 92077770000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 74 (33.2 bits)