Macrophages '99

June 18 and 19, 1999 National Institute of Infectious

Diseases I-23-1 Toyama, Shinjuku-ku, Tokyo

Conference Chairman: Kyoko Akagawa,

Department of lmmunology, National Institute of

Infectious Diseases

 Molecular Biology of Osteoclasts

1.   Yoshiya Tanaka (Univ of Occupational and

Environmental Health) Adhesion molecules on

osteoblasts in osteoclast differentiation       

2.   Yoshiyuki Hakeda (Meikai Univ, School of

Dentistry) Role of Tyro3, a receptor tyrosine

kinase, in bone resorption by mature osteoclasts

3.   Hiroshi Kawaguchi (Univ of Tokyo, Japan)

  Mechanism of low tumover osteopenia in

the Klotho-deficient mouse exhibiting multiple

aging phenotypes

4.   Yongwon Choi (Rockfeller Univ, USA) A TNF

family member, TRANCE: Its role and mode of


5.   Kyoji Yamaguchi (Snow Brand Milk Products

Co., Ltd.) A new pair of TNF ligand-receptor

family proteins modulating osteoclastogenesis

Infection and Macrophages

1.   Shizuo Akira (Osaka Univ) MyD88 knockout and

Toll-like receptor 4 knockout mice are

hyporesponsive to endotoxin

2.   Haruki Okamura (Hyogo College of Medicine) Interleukin-18, a pro-inflammatory cytokine

  produced by macrophages

3.   Fumio Kishi (Yamaguchi Univ) Functional

analysis of natural resistance-associated and

macrophage proteins

4.   Kunisuke Himeno (Univ of Tokushima) Roles of

heat shock protein in hostdefense and parasite-

evasion in malaria infection

5.   Karl-Heinz Krause (Geneva Univ, Hospitals,

  Switzerland) NADPH oxidases and H+ channels

Macrophage and Dendritic Cell Diversity in Origin and Function (Part 1)

1.   Alexander Medvinsky (Univ of Edinburgh,

UK) Development of the definitive haemato-

poietic stem cell

2.   Yoshimoto Katsura (Kyoto Univ) On the Process

of lineage commitment of the hematopoietic stem

cell to T, B and myeloid cells

Macrophage and Dendritic Cell Diversity in Origin and Function (Part 2)     .

1.   Gwendalyn J. Randolph (Weill Medical College

of Cornell Univ, USA) Differentiation of monocytes into dendritic cells in models of lymphatic clearance

2.   Kiyoko Akagawa (National Institute of lnfectious

Diseases) Functional heterogeneity of human

monocyte-derived macrophages

3.   Shin-ichi Hashimoto (Univ of Tokyo) Serial

analysis of gene expression in hunian monocytes,

macrophages and dendritjc cells