生物機能開発化学研究室 東京大学  大学院農学生命科学研究科  応用生命化学専攻

Laboratory of Biological Function Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo



2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015以前


Narukawa, M.*, and Misaka, T.
Identification of mouse bitter taste receptors that respond to resveratrol, a bitter-tasting polyphenolic compound.
Biosci. Biotechnol. Biochem., in press

Narukawa, M.*, Mori, Y., Nishida, R., Takahashi, S., Saito, T., Saido, T.C., and Misaka, T.*
Expression of olfactory-related genes in the olfactory epithelium of an Alzheimer’s disease mouse model.
J. Alzheimers Dis., 88, 29-35, 2022.


Toda, Y.#, Hayakawa, T.#, Itoigawa, A., Kurihara, Y., Nakagita, T., Hayashi, M., Ashino, R., Melin, A.D., Ishimaru, Y., Kawamura, S.*, Imai, H.*, and Misaka, T.*
Evolution of the primate glutamate taste sensor from a nucleotide sensor.
Curr. Biol., 31, 4641-4649, 2021.
[Article] [研究紹介]

Narukawa, M.*, and Misaka, T.
Change in taste preference to capsaicin and catechin due to aging in mice.
J. Nutr. Sci. Vitaminol.,67, 196-200, 2021.

Narukawa, M.*, Takahashi, S., Kamiyoshihara, A., Matsumiya, K., and Misaka, T.*
Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice.
PLoS One, 16, e0248673, 2021.

Yanagisawa, T.* and Misaka, T.
Characterization of the human bitter taste receptor response to sesquiterpene lactones from edible Asteraceae species and suppression of bitterness through pH control.
ACS Omega, 6, 4401-4407, 2021.

Hashimoto, M.*, Nakagita, T., and Misaka, T. (Review)
Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor.
RSC Adv., 11, 32236-32247, 2021.

Kasahara, Y., Narukawa, M., Kanda, S., Tominaga, M., Abe, K., Misaka, T., and Asakura, T.*
Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste.
Biosci. Biotechnol. Biochem., 85, 2295-2299, 2021.

Kasahara, Y.#, Narukawa, M.#, Nakagita, T., Abe, K., Misaka, T., and Asakura, T.*
Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4.
Biochem. Biophys. Res. Commun., 573, 76-79, 2021.

Kasahara, Y.#, Narukawa, M.#, Ishimaru, Y., Kanda, S., Umatani, C., Takayama, Y., Tominaga, M., Oka, Y., Kondo, K., Kondo, T., Takeuchi, A., Misaka, T., Abe, K.*, and Asakura, T.*
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
J. Physiol. Sci., 71, 23, 2021.

Takashima, Y., Ishikawa, K., Miyawaki, R., Ogawa, M., Ishii, T., Misaka, T., and Kobayashi, S.*
Modulatory effect of theaflavins on apical sodium-dependent bile acid transporter (ASBT) activity.
J. Agric. Food Chem., 69, 9585-9596, 2021.

Toda, Y., Ko, M.C., Liang, Q., Miller, E.T., Rico-Guevara, A., Nakagita, T., Sakakibara, A., Uemura, K., Sackton, T., Hayakawa, T., Sin, S.Y.W., Ishimaru, Y., Misaka, T., Oteiza, P., Crall, J., Edwards, S., Buttemer, W., Matsumura, S., and Baldwin, M.W.*
Early origin of sweet perception in the songbird radiation.
Science, 373, 226-231, 2021.
[PubMed] [研究紹介]

Ohkubo, S., Terauchi, K., Okada, S., Saito, Y., Yamaura, T., Misaka, T., Nakajima, K., Abe, K., and Asakura, T.*
De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits.
BMC Genomics, 22, 347, 2021.


Nakagita, T., Taketani, C.,Narukawa, M., Hirokawa, T., Kobayashi, T., and Misaka, T.*
Ibuprofen, a nonsteroidal anti-inflammatory drug, is a potent inhibitor of the human sweet taste receptor.
Chem. Senses, 45, 667-673, 2020.

Narukawa, M., Takahashi, S., Saito, T., Saido, T.C., and Misaka, T.*
Analysis of taste sensitivities in App knock-in mouse model of Alzheimer's disease.
J. Alzheimers Dis., 76, 997-1004, 2020.

Narukawa, M., Kamiyoshihara, A., Izu, H., Fujii, T., Matsubara, K., and Misaka, T.*
Efficacy of long-term feeding of α-glycerophosphocholine for aging-related phenomena in old mice.
Gerontology, 66, 275-285, 2020.

Yamazaki, T.*, Takahashi, C., Taniguchi, Y., Narukawa, M., Misaka, T., and Ano, Y.
Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells.
Biochem. Biophys. Res. Commun., 533, 704-709, 2020.

Rhyu, M.R.*, Kim, Y., and Misaka, T.
Suppression of hTAS2R16 signaling by umami substances.
Int. J. Mol. Sci., 21, E7045, 2020.

Nakagita, T., Ishida, A., Tachrim, Z.P., Wang, L., Misaka, T., and Hashimoto, M.*
Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors.
Molecules, 25, E2790, 2020.


Fu, O., Iwai, Y., Narukawa, M., Ishikawa, A.W., Ishii, K.K., Murata, K., Yoshimura, Y., Touhara, K., Misaka, T., Minokoshi, Y., and Nakajima, K.*
Hypothalamic neuronal circuits regulating hunger-induced taste modification.
Nat. Commun., 10, 4560, 2019.

Fu, O., Iwai, Y., Kondoh, K., Misaka, T., Minokoshi, Y., and Nakajima, K.*
SatB2-expressing neurons in the parabrachial nucleus encode sweet taste.
Cell Rep., 27, 1650-1656, 2019.

Nakagita, T., Ishida, A., Matsuya, T., Kobayashi, T., Narukawa, M., Hirokawa, T., Hashimoto, M., and Misaka, T.*
Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.
PLoS One, 14, e0213552, 2019.

Ren, E., Watari, I., Jui-Chin, H., Mizumachi-Kubono, M., Podyma-Inoue, K.A., Narukawa, M., Misaka, T., Watabe, T., and Ono, T.*
Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rats’ circumvallate papillae.
Acta Histochem., 121, 135-142, 2019.

Kasahara, Y., Sakurai, T., Matsuda, R., Narukawa, M., Yasuoka, A., Mori, N., Watanabe, H., Okabe, T., Kojima, H., Abe, K., Misaka, T., and Asakura, T.*
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ.
Biosci. Biotechnol. Biochem., 83, 243-250, 2019.


Narukawa, M., Kamiyoshihara, A., Kawae, M., Kohta, R., and Misaka, T.*
Analysis of aging-dependent changes in taste sensitivities of the senescence-accelerated mouse SAMP1.
Exp. Gerontol., 113, 64-73, 2018.

Toda, Y., Nakagita, T., Hirokawa, T., Yamashita, Y., Nakajima, A., Narukawa, M., Ishimaru, Y., Uchida, R., and Misaka, T.*
Positive/negative allosteric modulation switching in an umami taste receptor (T1R1/T1R3) by a natural flavor compound, methional.
Sci. Rep., 8, 11796, 2018.
[PubMed] [研究紹介]

Narukawa, M.*, and Misaka, T.
Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity of mice.
Biochem. Biophys. Res. Commun., 503, 2301-2305, 2018.

Narukawa, M.* (Review)
Physiological responses to taste signals of functional food components.
Biosci. Biotechnol. Biochem., 82, 200-206, 2018.

Abe, K.* and Misaka, T. (Review)
Food functionality research as a new national project in special reference to improvement of cognitive and locomotive abilities.
Biosci. Biotechnol. Biochem., 82, 573-583, 2018.


Narukawa, M., Kurokawa, A., Kohta, R., and Misaka, T.*
Participation of the peripheral taste system in aging-dependent changes in taste sensitivity.
Neuroscience, 358, 249-260, 2017.

Maeda, N.#, Narukawa, M.#, Ishimaru, Y., Yamamoto, K., Misaka, T., and Abe, K.*
A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons.
Neurosci. Lett., 648, 53-58, 2017.


Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., and Abe, K.*
Expression of serotonin receptor genes in cranial ganglia.
Neurosci. Lett., 617, 46-51, 2016.

Yoshimoto, J., Okada, S., Kishi, M., and Misaka, T.*
Ulex europaeus agglutinin-1 is a reliable taste bud marker for in situ hybridization analyses.
J. Histochem. Cytochem., 64, 205-215, 2016.

Ishimaru, Y.*, Kozuka, C.*, Nakajima, K.*, and Sasaki, T.* (Review)
Expanding frontiers in weight-control research explored by young investigators.
J. Physiol Sci., 67, 83-95, 2016.

Tsutsui, K., Otoh, M., Sakurai, K., Suzuki-Hashido, N., Hayakawa, T., Misaka, T., Ishimaru, Y., Aureli, F., Melin, A.D., Kawamura, S.*, and Imai, H.*
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.
BMC Evol. Biol., 16, 208, 2016.

Imai, H.*, Suzuki-Hashido, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Ishiguro, M., Masuda, K., Abe, K., Misaka, T., and Hirai, H.
Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to beta-glycosides.
Biophys. Physicobiol., 13, 165-171, 2016.

Ushiama, S.#, Ishimaru, Y.#*, Narukawa, M.#, Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe K.*
Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.
EBioMedicine, 8, 60-71, 2016.

Nakajima, K.#, Cui, Z.# , Li, C., Meister, J., Cui, Y., Fu, O., Smith, A.S., Jain, S., Lowell, B.B., Krashes, M.J., and Wess, J.*
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.
Nat. Commun., 7, 10268, 2016.
[PubMed] [研究紹介]

2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015以前

東京大学 大学院農学生命科学研究科 応用生命化学専攻
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