生物機能開発化学研究室 東京大学  大学院農学生命科学研究科  応用生命化学専攻

Laboratory of Biological Function Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

研究業績

2022/1/4更新

2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015以前

2022年



2021年

Toda, Y.#, Hayakawa, T.#, Itoigawa, A., Kurihara, Y., Nakagita, T., Hayashi, M., Ashino, R., Melin, A.D., Ishimaru, Y., Kawamura, S.*, Imai, H.*, and Misaka, T.*
Evolution of the primate glutamate taste sensor from a nucleotide sensor.
Curr. Biol., 31, 4641-4649, 2021.
[Article] [研究紹介]

Narukawa, M.*, and Misaka, T.
Change in taste preference to capsaicin and catechin due to aging in mice.
J. Nutr. Sci. Vitaminol.,67, 196-200, 2021.
[Article]

Narukawa, M.*, Takahashi, S., Kamiyoshihara, A., Matsumiya, K., and Misaka, T.*
Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice.
PLoS One, 16, e0248673, 2021.
[Article]

Yanagisawa, T.* and Misaka, T.
Characterization of the human bitter taste receptor response to sesquiterpene lactones from edible Asteraceae species and suppression of bitterness through pH control.
ACS Omega, 6, 4401-4407, 2021.
[Article]



Hashimoto, M.*, Nakagita, T., and Misaka, T. (Review)
Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor.
RSC Adv., 11, 32236-32247, 2021.
[Article]

Kasahara, Y., Narukawa, M., Kanda, S., Tominaga, M., Abe, K., Misaka, T., and Asakura, T.*
Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste.
Biosci. Biotechnol. Biochem., 85, 2295-2299, 2021.
[PubMed]

Kasahara, Y.#, Narukawa, M.#, Nakagita, T., Abe, K., Misaka, T., and Asakura, T.*
Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4.
Biochem. Biophys. Res. Commun., 573, 76-79, 2021.
[PubMed]

Kasahara, Y.#, Narukawa, M.#, Ishimaru, Y., Kanda, S., Umatani, C., Takayama, Y., Tominaga, M., Oka, Y., Kondo, K., Kondo, T., Takeuchi, A., Misaka, T., Abe, K.*, and Asakura, T.*
TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
J. Physiol. Sci., 71, 23, 2021.
[Article]

Takashima, Y., Ishikawa, K., Miyawaki, R., Ogawa, M., Ishii, T., Misaka, T., and Kobayashi, S.*
Modulatory effect of theaflavins on apical sodium-dependent bile acid transporter (ASBT) activity.
J. Agric. Food Chem., 69, 9585-9596, 2021.
[PubMed]

Toda, Y., Ko, M.C., Liang, Q., Miller, E.T., Rico-Guevara, A., Nakagita, T., Sakakibara, A., Uemura, K., Sackton, T., Hayakawa, T., Sin, S.Y.W., Ishimaru, Y., Misaka, T., Oteiza, P., Crall, J., Edwards, S., Buttemer, W., Matsumura, S., and Baldwin, M.W.*
Early origin of sweet perception in the songbird radiation.
Science, 373, 226-231, 2021.
[PubMed] [研究紹介]

Ohkubo, S., Terauchi, K., Okada, S., Saito, Y., Yamaura, T., Misaka, T., Nakajima, K., Abe, K., and Asakura, T.*
De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits.
BMC Genomics, 22, 347, 2021.
[Article]

2020年

Nakagita, T., Taketani, C.,Narukawa, M., Hirokawa, T., Kobayashi, T., and Misaka, T.*
Ibuprofen, a nonsteroidal anti-inflammatory drug, is a potent inhibitor of the human sweet taste receptor.
Chem. Senses, 45, 667-673, 2020.
[PubMed]

Narukawa, M., Takahashi, S., Saito, T., Saido, T.C., and Misaka, T.*
Analysis of taste sensitivities in App knock-in mouse model of Alzheimer's disease.
J. Alzheimers Dis., 76, 997-1004, 2020.
[PubMed]

Narukawa, M., Kamiyoshihara, A., Izu, H., Fujii, T., Matsubara, K., and Misaka, T.*
Efficacy of long-term feeding of α-glycerophosphocholine for aging-related phenomena in old mice.
Gerontology, 66, 275-285, 2020.
[PubMed]



Yamazaki, T.*, Takahashi, C., Taniguchi, Y., Narukawa, M., Misaka, T., and Ano, Y.
Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells.
Biochem. Biophys. Res. Commun., 533, 704-709, 2020.
[PubMed]

Rhyu, M.R.*, Kim, Y., and Misaka, T.
Suppression of hTAS2R16 signaling by umami substances.
Int. J. Mol. Sci., 21, E7045, 2020.
[PubMed]

Nakagita, T., Ishida, A., Tachrim, Z.P., Wang, L., Misaka, T., and Hashimoto, M.*
Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors.
Molecules, 25, E2790, 2020.
[PubMed]

2019年

Fu, O., Iwai, Y., Narukawa, M., Ishikawa, A.W., Ishii, K.K., Murata, K., Yoshimura, Y., Touhara, K., Misaka, T., Minokoshi, Y., and Nakajima, K.*
Hypothalamic neuronal circuits regulating hunger-induced taste modification.
Nat. Commun., 10, 4560, 2019.
[PubMed][研究紹介]

Fu, O., Iwai, Y., Kondoh, K., Misaka, T., Minokoshi, Y., and Nakajima, K.*
SatB2-expressing neurons in the parabrachial nucleus encode sweet taste.
Cell Rep., 27, 1650-1656, 2019.
[PubMed][研究紹介]

Nakagita, T., Ishida, A., Matsuya, T., Kobayashi, T., Narukawa, M., Hirokawa, T., Hashimoto, M., and Misaka, T.*
Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.
PLoS One, 14, e0213552, 2019.
[PubMed]



Ren, E., Watari, I., Jui-Chin, H., Mizumachi-Kubono, M., Podyma-Inoue, K.A., Narukawa, M., Misaka, T., Watabe, T., and Ono, T.*
Unilateral nasal obstruction alters sweet taste preference and sweet taste receptors in rats’ circumvallate papillae.
Acta Histochem., 121, 135-142, 2019.
[PubMed]

Kasahara, Y., Sakurai, T., Matsuda, R., Narukawa, M., Yasuoka, A., Mori, N., Watanabe, H., Okabe, T., Kojima, H., Abe, K., Misaka, T., and Asakura, T.*
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ.
Biosci. Biotechnol. Biochem., 83, 243-250, 2019.
[PubMed]

2018年

Narukawa, M., Kamiyoshihara, A., Kawae, M., Kohta, R., and Misaka, T.*
Analysis of aging-dependent changes in taste sensitivities of the senescence-accelerated mouse SAMP1.
Exp. Gerontol., 113, 64-73, 2018.
[PubMed]

Toda, Y., Nakagita, T., Hirokawa, T., Yamashita, Y., Nakajima, A., Narukawa, M., Ishimaru, Y., Uchida, R., and Misaka, T.*
Positive/negative allosteric modulation switching in an umami taste receptor (T1R1/T1R3) by a natural flavor compound, methional.
Sci. Rep., 8, 11796, 2018.
[PubMed] [研究紹介]

Narukawa, M.*, and Misaka, T.
Tas2r125 functions as the main receptor for detecting bitterness of tea catechins in the oral cavity of mice.
Biochem. Biophys. Res. Commun., 503, 2301-2305, 2018.
[PubMed]

Narukawa, M.* (Review)
Physiological responses to taste signals of functional food components.
Biosci. Biotechnol. Biochem., 82, 200-206, 2018.
[PubMed]



Abe, K.* and Misaka, T. (Review)
Food functionality research as a new national project in special reference to improvement of cognitive and locomotive abilities.
Biosci. Biotechnol. Biochem., 82, 573-583, 2018.
[PubMed]

2017年

Narukawa, M., Kurokawa, A., Kohta, R., and Misaka, T.*
Participation of the peripheral taste system in aging-dependent changes in taste sensitivity.
Neuroscience, 358, 249-260, 2017.
[PubMed]

Maeda, N.#, Narukawa, M.#, Ishimaru, Y., Yamamoto, K., Misaka, T., and Abe, K.*
A large increase of sour taste receptor cells in Skn-1-deficient mice does not alter the number of their sour taste signal-transmitting gustatory neurons.
Neurosci. Lett., 648, 53-58, 2017.
[PubMed]



2016年

Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., and Abe, K.*
Expression of serotonin receptor genes in cranial ganglia.
Neurosci. Lett., 617, 46-51, 2016.
[PubMed]

Yoshimoto, J., Okada, S., Kishi, M., and Misaka, T.*
Ulex europaeus agglutinin-1 is a reliable taste bud marker for in situ hybridization analyses.
J. Histochem. Cytochem., 64, 205-215, 2016.
[PubMed]



Ishimaru, Y.*, Kozuka, C.*, Nakajima, K.*, and Sasaki, T.* (Review)
Expanding frontiers in weight-control research explored by young investigators.
J. Physiol Sci., 67, 83-95, 2016.
[PubMed]

Tsutsui, K., Otoh, M., Sakurai, K., Suzuki-Hashido, N., Hayakawa, T., Misaka, T., Ishimaru, Y., Aureli, F., Melin, A.D., Kawamura, S.*, and Imai, H.*
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.
BMC Evol. Biol., 16, 208, 2016.
[PubMed]

Imai, H.*, Suzuki-Hashido, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Ishiguro, M., Masuda, K., Abe, K., Misaka, T., and Hirai, H.
Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to beta-glycosides.
Biophys. Physicobiol., 13, 165-171, 2016.
[Article]

Ushiama, S.#, Ishimaru, Y.#*, Narukawa, M.#, Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe K.*
Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.
EBioMedicine, 8, 60-71, 2016.
[PubMed]

Nakajima, K.#, Cui, Z.# , Li, C., Meister, J., Cui, Y., Fu, O., Smith, A.S., Jain, S., Lowell, B.B., Krashes, M.J., and Wess, J.*
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.
Nat. Commun., 7, 10268, 2016.
[PubMed] [研究紹介]

2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015以前

東京大学 大学院農学生命科学研究科 応用生命化学専攻
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