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Principal Investigators

Development of Antibody Nanosensor

I am aiming at a novel immunoassay utilizing the antigen-dependent stability change of antibody variable region. Through the noncompetitive detection of low molecular weight antigens of less than 1000 in MW, more rapid and sensitive environment-monitoring devices as well as those for clinical diagnostic will be realized. The objects include (1) development of the selection method of high-affinity antibodies suitable for the assay, (2) development of the methods to obtain suitable antibody fragments utilizing monoclonal Ab resources, and (3) application of the assay to nano-size detection devices.

Research interest
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Hiroshi UEDA
DATA
Affiliation Department of Chemistry and Biotechnology,
Graduate School of Engineering,
The University of Tokyo
Major Field Protein engineering, Immunoassay
Co-investigator Masaki UEDA
Jin Hua DONG
URL http://elisa.chem.t.u-tokyo.ac.jp/
TEL +81-3-5841-7362
FAX +81-3-5841-7362
MAIL MAIL
Address  7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656
Co-worker Takehiko KITAMORI
Masaru KATO
Toshiya SAKATA

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