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Overview| President Junichi Hamada | Director Kazunori Kataoka |

information
  • 2012.10.17
    Polymeric micelles as nano-scaled Trojan Horse was highlighted in the web site of Nature Japan for the successful chemothrapy to treat drug-resistant tumors. (Details)

  • 2011. 2. 10
    Polymeric micelles as nano-scaled Trojan Horse was highlighted in the web site of Nature Japan for the successful chemothrapy to treat drug-resistant tumors. (Details)

  • 2011. 1. 28
    Targeting therapy to treat drug-resistant tumor by polymeric micelles were carried in Nikkei Sangyo Shimbun. (Details)

  • 2011. 1. 6
    Our paper entitled "Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting" was selected as a cover of Sci. Transl. Med.(Vol.3, No.64, January 2011) (The pdf file is available from here) and the research of the paper was carried in Nippon Keizai Newspaper, Mainichi Newspaper, Yomiuri Newspaper, NHK News etc. (Details)

  • September 9, 2010: Parliamentary Secretary of Cabinet Office for Economic and Fiscal Policy, Science and Technology Policy, and Promotion of Local Sovereignty, Keisuke Tsumura visited Center for Nanobio Integration and Nanobio First project in the Tokyo University. After projects were reviewed by Professor Kataoka and Mr. Tsumura visited research facilities and communicated with researchers.

  • September 2, 2010: Dr. Cristina Garmendia, the Minister of Science Innovation, Spain, and her delegates visited CNBI to inspect our FIRST project on nanobiotechnolgy and drug delivery.

  • GCOE Medical Innovation Seminar
      March, 27, 2013
      Empowering Natural Product Drug Discovery through Biosynthesis, Prof.Bradley S. Moore(Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, UCSD, USA) PDF  Registration

      March, 27, 2013
      Indigenous-guided Investigation of the Northern Kaanju Medicinal Plant, Dodonaea Polyandra, Prof. Ross McKinnon(Flinders Centre for Innovation in Cancer, Flinders University, South Australia / University of South Australia, Adelaide, South Australia, Australia) PDF  Registration

      March, 26, 2013
      Combinatorial Mining of New Biosynthetic Pathways and Their Associat ed Natural Products, Prof.Wen Liu(Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China) PDF  Registration

      March, 22, 2013
      Dr. Yuji Heike(National Cancer Center Hospital) PDF  Registration

      March, 14, 2013
      Advance in Light Microendoscopy, Dr. Wibool Piyawattanametha(Advanced Imaging Research (AIR) Center, Faculty of Medicine, Chulalongkorn University, Thailand) PDF  Registration

  • Symposium Cooperated by CNBI
      March 15-18, 2011
      International Conference on Biomaterials Science 2011 (ICBS2011)
      Overview

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What's New
  • 130th GCOE Medical Innovation Seminar(January 25, 2013)
    Ligand-Directed Therapy and Molecular Imaging Based on in vivo Phage Display Technology, Prof. Renata Pasqualini & Prof. Wadih Arap(The University of Texas M. D. Anderson Cancer Center, USA) PDF

  • 129th GCOE Medical Innovation Seminar(January 22, 2013)

    Instructive Nanofibrous Scaffolds for Cardiac Tissue Engineering, Dr. Patrick C.H. Hsieh(National Cheng Kung University & Hospital, Tainan, Taiwan/Taiwan Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan) PDF

  • 128th GCOE Medical Innovation Seminar(January 11, 2013)

    Organics, Polymers and Organic-Inorganic Hybrid Materials for Photonic Applications, Prof.Kwang-Sup Lee(Department of Advanced Materials, Hannam University, Korea) PDF

  • 127th GCOE Medical Innovation Seminar(December 14, 2012)
    Simple Strategies to Produce Complex Non-toxic Anti-biofouling Coatingss, Dr. Karen L. Wooley(Texas A&M University, U.S.A) PDF

  • 126th GCOE Medical Innovation Seminar(December 13, 2012)
    Secondary Metabolites of Symbiotic Bacteria in Insect Ecosystems, Dr. Dong-Chan Oh(HHMI International Early Career Scientist College of Pharmacy, Seoul National University, Korea) PDF

  • 125th GCOE Medical Innovation Seminar(December 11, 2012)
    Molecular Genetic Mining of the Aspergillus Secondary Metabolome, Dr. Clay Wang, (University of Southern California, USA) PDF

  • 124th GCOE Medical Innovation Seminar(November 20, 2012)
    Recent Advances in Aminocoumarin Antibiotic Biosynthesis: Pyrroles, Adenylating Enzymes and MbtH-like Proteins, Prof., Heide(Pharmaceutical Biology, Pharmaceutical Institute Eberhard-Karls-Universitat Tubingen, Germany) PDF

  • 123th GCOE Medical Innovation Seminar(November 19, 2012)
    Cooperative Self-Assembly and Self-Sorting of pi-Conjugated Systems, Dr. Gustavo Fernandez(Institute of Organic Chemistry, University of Wurzburg, Germany) PDF

  • 122th GCOE Medical Innovation Seminar(November 13, 2012)

    How to Write Great Papers: from Title to References, from Submission to Publication, Dr. Harten(Elsevier BV, Amsterdam, The Netherlands) PDF

  • 121th GCOE Medical Innovation Seminar(November 12, 2012)

    Dr. Fujimoto(Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center,U.S.A) PDF

  • 120th GCOE Medical Innovation Seminar(October 30, 2012)

    Synthesis of Covalent Cylindrical Objects and Covalent Monomolecular Sheets, Prof. A.Dieter Schluter(ETH Zurich, Switzerland) PDF

  • 119th GCOE Medical Innovation Seminar(22 October, 2012)
    Chemical and biochemical evolution written in the genomes of sunflower family, Dr. Dae-Kyun Ro(Department of Biololgical Sciences, University of Calgary, Canada) PDF

  • 118th GCOE Medical Innovation Seminar(10 October, 2012)
    Function of RNA-binding Proteins in Immune Response, Prof. Ulus Atasoy(Surgery and Molecular Microbiology & Immunology, School of Medicine, University of Missouri Health System, USA) PDF

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Overview
Photo「研究機関代表 東京大学総長 濱田純一」
President of The University of Tokyo
Junichi Hamada

The world today is facing a period of dramatic changes. As industry and economy are suffering great instability on a global scale and the foundations of individuals’ livelihoods are being eroded, society is searching for a reliable compass to the future. Academia is expected to sketch the outline of this future society and mark the path to reach that goal. The University of Tokyo is committed to fulfilling its public responsibility through academic research and fostering of new talent, thus providing a reliable compass to the future.  To fulfill this purpose, we will focus not just on scholarship for acclaim today, but also ensure the sustenance, continued development and integration of diverse disciplines so that we can enrich the foundations of knowledge and nurture new sources of creativity.
In the medical field, although systematic molecular-level investigations into the cause of diseases are proceeding at a rapid rate, individual basic academic knowledge does not effectively lead to treatment of diseases. To solve this problem, it is necessary to conduct both basic academic research and innovative and integrative approaches. The University of Tokyo Center for NanoBio Integration will be a pioneering research center that integrates knowledge dispersed among different disciplines including biosensing technology, biomaterial technology, molecular simulation technology and nanoscale-biotechnology toward the medical applications.
 I believe that through the creation of knowledge, through education and through close association with society, now more than ever is the time in which the University of Tokyo must fulfill its public responsibility towards the future of Japan and of the world community. As a “Global Cornerstone of Human Knowledge”, the University of Tokyo, with its abundant conceptual powers, is determined to forge ahead on the pathway to that future.


Photo「研究拠点リーダー 片岡 一則」
Center Director
Kazunori Kataoka

In recent years, in science and engineering fields, assembly technology on a microscale or even nanoscale has made great strides. Not only in semiconductor technology, but also in mechanical engineering, micro/nanomachining technology based on micro/nano manufacturing and micro/nano assembly has been increasingly sophisticated, making steady progress toward high-performance and high-precision. On the other hand, in materials science and materials engineering, in addition to traditional design methods based on macroproperty, materials design based on nanoassembly that manipulates molecules and atoms has appeared, making a high impact on highly advanced functional materials area. The progresses in hardware including assembly, micronization and intellectualization are helping integrate materials science, materials engineering, electronic engineering and mechanical engineering that have been separately evolving based on the unique concepts. In other words, advances are helping integrate the bottom-up method of atomic or molecular assembly and top-down method of nano/microscopic manufacturing."Nano integration" is defined as the integration of sophisticated systems into materials on a nanoscale. On reflection, such"nano integration" can be seen in a large number of our body structures that govern complicated functions, suggesting that"nano integration" is a process suitable for biological evolution. In this sense, to further the development of sophisticated device systems based on"nano integration", it is important to promote research and development on"nanobio integration", including the understanding of structures and functions of the body on a nanoscale, the creation of structures and functions inspired by the operational principles of the body and the establishment of the methodology that regulates the functions of body components including biomolecules and cells and integrates them into devices.

"Nanobio integration", a concept covering traditional science and technology fields, is expected to develop in broad areas of industries, especially life science and biotechnology fields. Throughout the 20th century, life science and biotechnology have made tremendous progress and have contributed to building a safe and secure society through overcoming a number of intractable diseases and enhancing food and environmental safety. Moreover, in the 21st century, based on the integration of vast amounts of knowledge from molecular biology and cellular biology, rapid progress has been made in innovative medical technologies represented by gene diagnosis and therapy and tissue engineering. Environmental assessment techniques and alternative techniques for animal experiments which integrate the body system including proteins and cells have been developed. Even biosynthesis and bioprocessing technologies, inspired by smart body structures and functions, have been created. In the 20th century, the primary focus was placed on"research on the biological system at molecular and cellular levels." In the 21st century, an additional focus has been placed on utilization of the biological system at molecular and cellular levels.

Promoting nanodevice system research which highly integrates the above-mentioned life science and biotechnology, the Center for NanoBio Integration aims to create the interdisciplinary scientific technological system and intellectual basis that explore and reveal the nature of the biological functions on a nanoscale and to promote the construction of an innovative"nanomedical" system based on nanoscale spatiotemporal bioregulation and the establishment of new bioindustries that open up the future for our country. All of our members work hard and enthusiastically to produce and disseminate innovative research results"that may astonish the world". Your advice and support are greatly appreciated.




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