大黒耕
経歴
1983年 神奈川県横須賀市生まれ
2006年3月 慶応義塾大学理工学部生命情報学科卒業
2008年3月 東京大学大学院工学系研究科化学生命工学専攻修士課程修了
2011年3月 東京大学大学院工学系研究科化学生命工学専攻博士課程修了
この間、2008年4月〜2011年3月 日本学術振興会特別研究員（DC1）
2011年4月 東京大学大学院工学系研究科化学生命工学専攻 助教
受賞
2017年 日本化学会第97春季年会、優秀講演賞（学術）
2019年 日本化学会進歩賞
興味のある分野
有機化学・超分子化学・バイオミメティクス・ケミカルバイオロジー・生体適合性材料
論文
Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues
Ai Kohata, P. K. Hashim, Kou Okuro, and Takuzo Aida
J. Am. Chem. Soc. 2019, 141, in press.
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
Rina Mogaki, Kou Okuro, Akio Arisaka, and Takuzo Aida
J. Vis. Exp. 2019, 143, e58631.
Dendritic Molecular Glues with Reductively Cleavable Guanidinium Ion Pendants: Highly Efficient Intracellular siRNA Delivery via Direct Translocation
Kou Okuro, Harei Nemoto, Rina Mogaki, and Takuzo Aida
Chem. Lett. 2018, 47, 1232–1235.
Nitrobenzoxadiazole-Appended Cell Membrane Modifiers for Efficient Optoporation with Noncoherent Light
Saya Otake, Kou Okuro, Davide Bochicchio, Giovanni M. Pavan, and Takuzo Aida
Bioconjugate Chem. 2018, 29, 2068–2073.
Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells
Akio Arisaka, Rina Mogaki, Kou Okuro, and Takuzo Aida
J. Am. Chem. Soc. 2018, 140, 2687–2692.
Mechanically Robust, Readily Repairable Polymers via Tailored Noncovalent Cross-linking
Yu Yanagisawa, Yiling Nan, Kou Okuro, and Takuzo Aida
Science 2018, 359, 72–76.
Guanidinium-based “Molecular Glues” for Modulation of Biomolecular Functions
Rina Mogaki, P. K. Hashim, Kou Okuro, and Takuzo Aida
Chem. Soc. Rev. 2017, 46, 6480–6491.
Adhesive Photoswitch: Selective Photochemical Modulation of Enzymes under Physiological Conditions
Rina Mogaki, Kou Okuro, and Takuzo Aida
J. Am. Chem. Soc. 2017, 139, 10072–10078.
Boronic Acid-Appended Molecular Glues for ATP-Responsive Activity Modulation of Enzymes
Kou Okuro, Mizuki Sasaki, and Takuzo Aida
J. Am. Chem. Soc. 2016, 138, 5527–5530.
Photoinduced Bioorthogonal 1,3-Dipolar Polycycloaddition Promoted by Oxianionic Substrates for Spatiotemporal Operation of Molecular Glues.
Junichi Hatano, Kou Okuro, and Takuzo Aida
Angew. Chem., Int. Ed. 2016, 55, 193–198.
Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization
P. K. Hashim, Kou Okuro, Shigekazu Sasaki, Yasutaka Hoashi, and Takuzo Aida
J. Am. Chem. Soc. 2015, 137, 15608–15611.
Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues
Rina Mogaki, Kou Okuro, and Takuzo Aida
Chem. Sci. 2015, 6, 2802–2805.
Subnanoscale Hydrophobic Modulation of Salt Bridges in Aqueous Media
Shuo Chen, Yoshimitsu Itoh, Takuya Masuda, Seishi Shimizu, Jun Zhao, Jing Ma, Shugo Nakamura, Kou Okuro, Hidenori Noguchi, Kouhei Uosaki, and Takuzo Aida
Science 2015, 348, 555–559.
Structure and Shape Effects of Molecular Glue on Supramolecular Tubulin Assemblies
Matteo Garzoni, Kou Okuro, Noriyuki Ishii, Takuzo Aida, and Giovanni M. Pavan
ACS Nano 2014, 8, 904–914.
Photoclickable Dendritic Molecular Glue: Noncovalent-to-Covalent Photochemical Transformation of Protein Hybrids
Noriyuki Uchida, Kou Okuro, Yamato Niitani, Xiao Ling, Takayuki Ariga, Michio Tomishige, and Takuzo Aida
J. Am. Chem. Soc. 2013, 135, 4684–4687.
Friction-Mediated Dynamic Disordering of Phospholipid Membrane by Mechanical Motions of Photoresponsive Molecular Glue: Activation of Ion Permeation
Yushi Suzuki, Kou Okuro, Tadashi Takeuchi, and Takuzo Aida
J. Am. Chem. Soc. 2012, 134, 15273–15276.
Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP-driven Sliding Motion of Actomyosin
Kou Okuro, Kazushi Kinbara, Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, and Takuzo Aida
Angew. Chem., Int. Ed. 2010, 49, 3030–3033.
High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder
Qigang Wang, Justin L Mynar, Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, and Takuzo Aida
Nature 2010, 463, 339–343.
Image analysis of α/β-tubulin rings in two-dimensional crystalline arrays of periodic mesoporous nanostructures
Noriyuki Ishii, Kou Okuro, Kazushi Kinbara, and Takuzo Aida
J. Biochem. 2010, 147, 555–563.
Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer: Stabilization of Microtubules against Depolymerization
Kou Okuro, Kazushi Kinbara, Kouhei Tsumoto, Noriyuki Ishii, and Takuzo Aida
J. Am. Chem. Soc. 2009, 131, 1626–1627.
Substrate specificity and reaction mechanism of recombinant styrene oxide isomerase from Pseudomonas putida S12
Kenji Miyamoto, Kou Okuro, and Hiromichi Ohta
Tetrahedron Lett. 2007, 48, 3255–3257.
‘Caged’ Molecular Glue in JoVE
LOG IN
大黒 耕
助教
東京大学大学院工学系研究科
化学生命工学専攻
okuro＠macro.t.u-tokyo.ac.jp